🗺Parasympthatic...... Rest and Digest

🗺Sympthatic...... Fight and Flight

📦 Safety of Azithromycin in pregnancy & lactation 📦

🟢Pregnancy 🟢

🔸Azithromycin is commonly used in pregnancy, although its safety, particularly during the first trimester, is unclear.

🔸While some studies suggest that azithromycin may be associated with congenital anomalies, this association is not consistently seen across studies and it is uncertain if the association is causal.

🔸Available data on use in pregnant women have not identified any drug-associated risks for major birth defects, miscarriage, or adverse maternal or fetal outcomes.

🔸In animal reproduction studies decreased viability and delayed development were observed in the offspring of pregnant rats administered azithromycin from day 6 of pregnancy through weaning at a dose equivalent to 4 times an adult human daily dose of 500 mg based on body surface area.

🟢Lactation 🟢

🔸Present in human milk.
🔸Non-serious adverse reactions have been reported in breastfed infants after maternal administration of Azithromycin.

🔸No data available on the effects of azithromycin on milk production.

🔸Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for azithromycin and any potential adverse effects on the breastfed infant from azithromycin or from the underlying maternal condition.

🔸Clinical considerations :
▶️Advise women to monitor the breastfed infant for diarrhea, vomiting, or rash

🀄️reference🀄️
🔸Uptodate 2023
🔸Medscape 2023

🟢 https://t.me/Vit3mins