So grateful to the many people who made this study possible. Special thank you to all the participants who did a heroic job of completing all the surveys and traveling to Yale to donate blood three times 🙏🏼 (end)

This prospective observational study led by @connorbgrady @bornali_27 @SilvaJ_C @hmkyale examined the impact of the primary COVID-19 vaccination on the symptoms and immune signatures of 16 people with #longCOVID. Here is what we found 👇🏼 (1/)

https://www.nature.com/articles/s43856-025-00829-3

Next week, we are hosting an international scientific workshop focused on the pathogenesis of #LongCovid at @YaleMed. Please join us on May 15th to learn about what we know and what we need to investigate next to get to the root causes ⏩ therapies 👇🏼👇🏼 @YaleCII

A great interview by @betsyladyzhets of @ahandvanish describing the upcoming @KeystoneSymp meeting on Long COVID and Post-Acute Infection Syndromes. How incredibly fortunate to have @ahandvanish as co-organizer of this important meeting 🙏🏼

https://x.com/thesicktimes/status/1920974665985524215?t=iQe3AcpxUDUIW227CckCVQ&s=19

Published today📣
Our nasal booster in the "Prime & Spike" vaccine works without adjuvants (which are needed to induce adaptive immunity but also cause inflammation). @Kwon_Dongil @tianyangmao @BenIsraelow et al. asked how this is possible. (1/)

https://www.nature.com/articles/s41590-025-02156-0

Finally, repeated nasal spike boosters elevated respiratory IgA responses even further. We hope the principle of a simple nasal viral antigen booster can be used for future vaccines that block infection and transmission against a variety of respiratory viruses. (4/)

Congratulations to the authors @Kwon_Dongil @tianyangmao @BenIsraelow @keylas3 and Huiping Dong for this incredible work 👏🏼👏🏼👏🏼 (end)

Published today! Victoria Bastos, @KerrieGreene_ et al found two distinct immunotypes of ME/CFS based on the cerebrospinal fluid analysis. Great collaboration with @MBVanElzakker @microbeminded2 and the Bragée clinic in Sweden. (1/)

https://academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf087/8133211?login=false

While we do not know why some people with ME/CFS have elevated MMPs and cytokines, our data suggest potentially distinct drivers of disease that manifest in similar clinical phenotypes. Future studies are needed to probe therapeutic pathways suitable for these clusters. (4/)

Congratulations to all the authors for this important work 👏🏼👏🏼👏🏼 We thank @weandmecfs @polybioRF and Carol Cirot Foundation, NIH and @HHMINEWS for supporting this work, and for all the patients for heroically donating CSF for our research 🙏🏼 (end)