Cancer Therapy Snapshot (Cell, 2023)

DALL·E 3 is here and it looks amazing!

Some thoughts:

From the announcement: "DALL·E 3 delivers significant improvements over DALL·E 2 when generating text within an image and in human details like hands. DALL·E 3 creates engaging images by default—no hacks or prompt engineering required."

Very curious to see to what extent we will rely on prompt engineering for this version. That has been one of the pain points for image generation systems, making them hard to use or get good results with.

OpenAI claims we won't need as much prompt engineering and that DALL·E 3 adheres better to prompt instructions and details.

Also, incredibly excited about the availability of DALL·E 3 in ChatGPT Plus and how this could improve the entire process of prompting and discovering interesting prompts to generate compelling and unique images. openai.com/dall-e-3

If you think that AI was born in 2022 👐🏾

CommunicatIon between neurons in the brain involves the release of either fast (for example, glutamate, γ-aminobutyric acid) or slow neurotransmitters (for example, catecholamines, histamine) from the presynaptic terminal, alone or together with neuromodulators. Fast neurotransmitters induce ion currents in the postsynaptic neuron. By contrast, slow neurotransmitters and neuromodulators act on metabotropic G protein–coupled receptors (GPCRs) in the postsynaptic membrane to trigger intracellular second messenger cascades. Neuropeptides are a superfamily of neuromodulators—more than 100 have been identified . However, studying neuropeptides is challenging owing to the limitations of available tools for their detection. Furthermore, despite decades of drug development aimed at neuropeptide-GPCRs, neither their localization nor the dynamics of ligand-induced activation is sufficiently understood. On page 786 of this issue, Wang et al. (1) describe GPCR-activation–based sensors (GRABs) that can track neuropeptide action in vivo. Such GRABs have the potential to provide new information on physiological processes (2) and the role of GPCRs in brain diseases.

https://www.science.org/doi/10.1126/science.adl1788

Interesting history of Pipette development and patents.


https://youtu.be/hW1pr8nDhhE

FIVE potential alternates to Sci-Hub

Sci-Hub has been a lifesaver for researchers across the globe, especially those who cannot afford to pay huge amounts to access key articles and are not associated with institutions that could offer access. Now that Sci-hub is partially/ fully shut down in several countries or crippled from uploading recent literature, are there any close alternatives?

1. Unpaywall: https://unpaywall.org/

An open database of 47,798,238 free scholarly articles. They harvest open-access content from over 50,000 publishers and repositories and make it easy to find, track, and use

2. Paper Panda: https://paperpanda.app/

This is a browser plug-in. A paywalled paper could be available through your library or university, or to download for free through an open access portal, maybe the author uploaded a PDF to a website somewhere – but how are you going to find it? Just click the tiny panda in your toolbar and the panda will run off and find the paper for you (all in the words of the creators)

3. Open Access Button: https://lnkd.in/gKRjY6fb

A browser extension that helps you to request for paywalled papers. Free, legal research articles delivered instantly or automatically requested from authors

4. Academia: https://www.academia.edu/

Academia.edu is a for-profit open repository of academic articles free to read by visitors. Uploading and downloading are restricted to registered users

5. LibGen: https://libgen.is/

This one is also a bit controversial and under court processes. They are also linked to resources from Sci-Hub. Libgen describes itself as a "links aggregator", providing a searchable database of items "collected from publicly available public Internet resources" as well as files uploaded "from users"

Where else can you access papers without huge subscription fees?

Copied from LinkedIn post of Sowmiya Rani, Ph.D. ⬇️⬇️⬇️

📩 sowmis.aww@gmail.com

We will witness the breakthroughs... 🤘

https://www.sciencedaily.com/releases/2024/01/240108153132.htm

#Microplastic #Nanoplastic 🤔

Minimal demo for GMXvg: A tool to plot #GROMACS .xvg files

GMXvg: Utility to Convert/Plot GROMACS XVG files Commandline based #GROMACS #XVG File plotting utility.

• Discovers all the XVG files in the current or subdirectories and converts them in specified file formats (default JPG).
• Logs the summary of plots in a file to quickly access the plot values along with their standard deviation values.


https://www.youtube.com/watch?v=99Eeqjp_0kI

Dear Scholars,

I am sorry that I cannot do much about DM messages from spammers as we really cannot distinguish if a user is genuine or a spammer. Please recheck the privacy setting of your telegram so that you don't make any sensitive or personal information public or accessible by random people.

Also, requesting you to share any problem you face in our groups or channel to @ScientificReporter, @TheBiomicsAdmin, or @TheBiomicsEditor.

Again sorry that we are helpless at this point as we want to maintain an accessible platform for the aspirants where we can share resources mutually.

🙏🏽

Hi Dear Members of @TheJournalClub

We are actively developing computational tools to assist research scholars. These tools are free and developed to help you assist in your journey. Just to help you automate your routine jobs.

Here are a few tools developed till now.

1. For bulk plotting of GROMACS XVG files https://github.com/TheBiomics/GMXvg
2. Python Functions to Process Files and Handle Data https://github.com/TheBiomics/UtilityLib
3. To convert images like to 600dpi 1200dpi tiff or JPG format etc https://github.com/TheBiomics/bimbmaan
4. Other web based tools at https://bi0.in/tool (sorry for ads)

We would love to solve any such problem where repetitive work is needed. You can share your problem. We will try to solve your problem through code. Additionally, anyone interested can collaborate with us to take these further.

If anyone seeking open source tool to delete, arrange, and/or merge pages in PDF file, PDFArranger tool is highly recommended. It is available for Windows and Linux.

Visit for binaries or installation instructions: https://github.com/pdfarranger/pdfarranger

To download to your PC visit: https://github.com/pdfarranger/pdfarranger/releases/tag/1.10.0

AlphaFold 3 😍