Mechanisms of action ef antibiotics include all the following EXCEPT
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15%
Interference with the cell membrane function
10%
Blocking DNA gyrase
5%
Inhibition of bacterial cell wall synthesis
70%
Inhibition of protein synthesis by acting on the 605 ribosomal subunit
Antimicrobial mode of action includes the following EXCEPT
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11%
Interference with I membrane function
17%
Inhibition of protein synthesis
33%
Selective toxicity
39%
Competitive inhibition
Which of the following antimicrobial agents is the most toxic to human?
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18%
Cephalosporin
18%
Penicillin
59%
Amphotericin B
6%
Vancomycin
Beta lactam antibiotics (eg. penicillin )
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88%
Inhibit bacterial cell wall synthesis
0%
Inhibit bacteria protein synthesis
0%
Inhibit bacterial nucleic acid synthesis
12%
Interfere with the cell membrane function
Cephalosporins
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18%
Are bacteriostatic
0%
Treat fungal infections
12%
Inhibit protein synthesis
71%
Are beta-lactam antibiotics
Which of the following is function of vancomycin?
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7%
Inhibition of nucleic acid synthesis
0%
Inhibition of protein synthesis
29%
Interference with cell membrane function
64%
Inhibition of cell wall synthesis
Which of the following antibiotics inhibits cell wall synthesis?
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56%
Bacitracin
8%
Macrolides
12%
Quinolones
24%
Tetracycline
The mechanism of action of the aminoglycosides is:
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0%
Inhibition of folic acid synthesis
21%
Interference with membrane function
71%
Binding to 305 ribosomal subunit
7%
Binding to 505 ribosomal subunit
Which of th following antibiotics inhibits bacterial protein synthesis by acting on the 305 ribosome subunit?
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9%
Macrolides
82%
Aminoglycosides
5%
Polymyxin
5%
Chloramphenicol
Which of the following antibiotics inhibits bacterial protein synthesis br on the 505 ribosomal subunit?
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55%
Chloramphenicol
25%
Trimethoprim
5%
Aminoglycosides
15%
Polymyxin
Inhibition of bacterial DNA synthesis occurs by
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11%
Polymyxin
5%
Chloramphenicol
79%
Quinolones
5%
Cephalosporins
The following mechanisms of antimicrobial agents are true EXCEPT:
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73%
Tetracyclines and aminoglycosides inhibit DNA gyrase
7%
Sulphonamides compete with para-amino benzoic acid
13%
Polymyxin and amphotericin 8 interfere with cell membrane functions
7%
Trimethoprim inhibits the dihydrofolic acid reductase enzyme
Regarding antibacterial agents, all the following are true EXCEPT:
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0%
Aminoglycosides act on 305 ribosomal subunit
8%
Quinolones inhibit DNA gyrase
92%
Cephalosporins compete with PABA
0%
Chloramphenicol acts on the 505 ribosomal subunit
The mechanism of action of quinolones is:
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0%
Inhibition of the dindrofolate reductase
8%
Inhibition of DNA-dependent RNA polymerase
0%
Inhibition of protein synthesis by binding to the 505 ribosomal subunit
92%
Inhibition of the DNA gyrase
Guidelines for choice of an antimicrobial agents include the following EXCEPT:
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10%
Choose bactericidal rather than bacteriostatic drugs
80%
Choose broad spectrum rather than narrow spectrum antibiotics
0%
Identify the nature of infection, whether bacterial, viral or fungal
10%
Select an antibiotic that is able to penetrate to the site of infection
Regarding broad-spectrum drugs, all the following are true EXCEPT:
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0%
Often used when the pathogen has not yet identified
0%
Can also kill or inhibit the patient's normal flora and cause superinfection
9%
Likely to induce resistance to antibiotics faster than narrow spectrum drugs
91%
Can only kill Gram positive bacteria
The following are mechanisms of acquired resistance EXCEPT:
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0%
Decreasing the influx of the antibiotic
9%
Modification of the receptor (target) site
9%
Target elimination by developing new metabolic pathways
82%
Absence of cell wall in Mycoplasma
A mutation in DNA gyrase is likely to result in resistance to
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6%
Amphotericin B
88%
Quinolones
0%
Rifampicin
6%
Cephalosporins
Antibiotic disc diffusion method:
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18%
Is done test allergic reaction of the patient to the antibiotic used
0%
Can accurately determine MIC of the antibiotic
73%
Depends on measuring the dimeter of zone of inhibition around the disc
9%
Utilizes filter paper discs impregnated with antibodies to the organism
Combined antibiotic therapy is indicated in the following conditions EXCEPT:
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0%
Mixed infections
86%
Viral meningitis
7%
Sepsis in immunocompromised patient
7%
Febrile neutropenia