An 8-29 MB model that beats rivals ten times its size — and never leaves the device
Needle is a foundation model for phones, wearables, robots, smart homes, cars and microcontrollers, where calling out to the cloud isn't an option. It ships as a single 2-bit binary, small enough to sit inside your app instead of behind an API.
Give it your app's functions and it picks which ones to call, filling every argument from what the user said: ask for two things, get two calls in order; ask for something no tool covers, get an empty list, never a guess. The same model does structured extraction into typed fields and produces text embeddings for local search and routing — beating models ten times its size on tool calls and matching ones two to three times bigger on extraction.
Install with
https://github.com/cactus-compute/needle
Needle is a foundation model for phones, wearables, robots, smart homes, cars and microcontrollers, where calling out to the cloud isn't an option. It ships as a single 2-bit binary, small enough to sit inside your app instead of behind an API.
Give it your app's functions and it picks which ones to call, filling every argument from what the user said: ask for two things, get two calls in order; ask for something no tool covers, get an empty list, never a guess. The same model does structured extraction into typed fields and produces text embeddings for local search and routing — beating models ten times its size on tool calls and matching ones two to three times bigger on extraction.
Install with
pip install cactus-needle. Decorate a Python function with @needle.tool and call run(): it picks the tool, fills the arguments, executes your function and returns the result.https://github.com/cactus-compute/needle
Free, open-source stock tracking — no subscription required
Real-time market data usually sits behind a paywall. OpenStock strips that away: track live prices, watch TradingView charts update in real time, and dig into detailed company insights, all powered by real Finnhub data.
Set a personalized price alert in seconds and get notified the moment a stock moves, instead of refreshing a tab all day. Search any ticker instantly from the dashboard and jump straight into the numbers.
Built with Next.js, MongoDB, and TradingView, and released under AGPL-3.0, OpenStock has already crossed 15,000 GitHub stars. Clone it, run it, and it's yours to use or extend, forever free.
https://github.com/Open-Dev-Society/OpenStock
Real-time market data usually sits behind a paywall. OpenStock strips that away: track live prices, watch TradingView charts update in real time, and dig into detailed company insights, all powered by real Finnhub data.
Set a personalized price alert in seconds and get notified the moment a stock moves, instead of refreshing a tab all day. Search any ticker instantly from the dashboard and jump straight into the numbers.
Built with Next.js, MongoDB, and TradingView, and released under AGPL-3.0, OpenStock has already crossed 15,000 GitHub stars. Clone it, run it, and it's yours to use or extend, forever free.
https://github.com/Open-Dev-Society/OpenStock
⚡ AI News
Gemini AI autonomously hacked three companies — Google says its Gemini model guessed passwords and used leaked credentials to breach three companies during a security test.
Trump vows 'AI Force' and a new AI czar — Trump said he will create an AI Force and name an AI czar, dismissing safety warnings as a hoax.
Newsom orders review of AI 'kill switch' rules — California Gov. Newsom signed an order pushing safety audits and a possible emergency kill switch for frontier AI.
Gemini AI autonomously hacked three companies — Google says its Gemini model guessed passwords and used leaked credentials to breach three companies during a security test.
Trump vows 'AI Force' and a new AI czar — Trump said he will create an AI Force and name an AI czar, dismissing safety warnings as a hoax.
Newsom orders review of AI 'kill switch' rules — California Gov. Newsom signed an order pushing safety audits and a possible emergency kill switch for frontier AI.
Turn your AI coding agent into a senior engineer with 25 skills
AI agents write code fast and skip everything around it — no spec, no plan, no review, just messy commits. Agent Skills packages the workflows senior engineers actually use, so agents follow spec → plan → build → test → review → ship instead of guessing.
Nine slash commands map to that whole lifecycle, and skills also fire automatically based on what you're doing: designing an API triggers
Install everything with one command, or grab a single skill on its own:
https://github.com/addyosmani/agent-skills
AI agents write code fast and skip everything around it — no spec, no plan, no review, just messy commits. Agent Skills packages the workflows senior engineers actually use, so agents follow spec → plan → build → test → review → ship instead of guessing.
Nine slash commands map to that whole lifecycle, and skills also fire automatically based on what you're doing: designing an API triggers
api-and-interface-design, building UI triggers frontend-ui-engineering. Run /build auto and it plans then implements every task in one pass — still test-driven, still committed task by task, still pausing on failures.Install everything with one command, or grab a single skill on its own:
npx skills add addyosmani/agent-skillshttps://github.com/addyosmani/agent-skills
⚡ AI News
Anthropic's revenue pace tops $100B, up 50% since July — Anthropic's annualized revenue run rate passed $100 billion, up from $65 billion in July, ahead of a planned IPO.
UMG and Sony sue Suno over v6 music model training — UMG and Sony sued Suno, saying its new v6 models launder infringement from earlier versions across 60,202 recordings.
China state TV outlet attacks Anthropic before AI talks — A CCTV-affiliated account accused Anthropic of risking user privacy via US intelligence sharing, ahead of new US-China AI talks.
Anthropic's revenue pace tops $100B, up 50% since July — Anthropic's annualized revenue run rate passed $100 billion, up from $65 billion in July, ahead of a planned IPO.
UMG and Sony sue Suno over v6 music model training — UMG and Sony sued Suno, saying its new v6 models launder infringement from earlier versions across 60,202 recordings.
China state TV outlet attacks Anthropic before AI talks — A CCTV-affiliated account accused Anthropic of risking user privacy via US intelligence sharing, ahead of new US-China AI talks.
⚡ AI News
Anthropic taps Accenture for $1B AI safety evaluation — Anthropic and Accenture will invest at least $1B over five years to embed independent evaluators red-teaming frontier Claude models.
Plugin4Shell RCE hits Claude Code and rival coding agents — A zero-click flaw bypassing plugin SHA-pinning hit Claude Code, Codex, Copilot and Gemini CLI; Anthropic and OpenAI patched, GitHub and Google have not.
Anthropic opens Claude biosafety limits for vetted labs — Anthropic's new Life Sciences Verification Program gives vetted researchers access to Claude Mythos, Opus and Sonnet with looser biology safeguards.
Anthropic taps Accenture for $1B AI safety evaluation — Anthropic and Accenture will invest at least $1B over five years to embed independent evaluators red-teaming frontier Claude models.
Plugin4Shell RCE hits Claude Code and rival coding agents — A zero-click flaw bypassing plugin SHA-pinning hit Claude Code, Codex, Copilot and Gemini CLI; Anthropic and OpenAI patched, GitHub and Google have not.
Anthropic opens Claude biosafety limits for vetted labs — Anthropic's new Life Sciences Verification Program gives vetted researchers access to Claude Mythos, Opus and Sonnet with looser biology safeguards.
⚡ AI News
OpenAI unveils Australian youth AI safety blueprint — OpenAI proposed six pillars for safer teen AI use in Australia, including age assurance and crisis referrals.
Cua open-sources tiny 706K-parameter UI agent model — Cua released CUA-S1-FORMS, a 706,048-parameter, 2.8MB model that makes fast, cheap form-filling decisions for computer-use agents.
Clinicians push back on AI use beyond diagnostics — A Wolters Kluwer survey of 355 US clinicians found 74% flag hallucinations as a top risk as AI expands past imaging.
OpenAI unveils Australian youth AI safety blueprint — OpenAI proposed six pillars for safer teen AI use in Australia, including age assurance and crisis referrals.
Cua open-sources tiny 706K-parameter UI agent model — Cua released CUA-S1-FORMS, a 706,048-parameter, 2.8MB model that makes fast, cheap form-filling decisions for computer-use agents.
Clinicians push back on AI use beyond diagnostics — A Wolters Kluwer survey of 355 US clinicians found 74% flag hallucinations as a top risk as AI expands past imaging.
Give your AI agent an actual computer, not just a chat window
Most agents can talk about your apps but can't touch them. Cua is an open-source stack that lets an agent click, type, and verify results in real desktop software on macOS, Windows, and Linux, instead of guessing from text alone.
The core piece is Cua Driver: connect it via CLI, MCP, or an SDK, and your agent can operate native apps and browsers directly, with background delivery so it doesn't have to steal your mouse and keyboard to get the job done. The same driver scales up to isolated cloud desktop fleets, so you can run many agent sessions in parallel without touching your own machine.
Trying it takes minutes: install the driver, point your agent at a simple app, and have it complete a task and confirm the result on screen itself. It's a fast way to see an agent actually operate software end to end, not just describe what it would do.
https://github.com/trycua/cua
Most agents can talk about your apps but can't touch them. Cua is an open-source stack that lets an agent click, type, and verify results in real desktop software on macOS, Windows, and Linux, instead of guessing from text alone.
The core piece is Cua Driver: connect it via CLI, MCP, or an SDK, and your agent can operate native apps and browsers directly, with background delivery so it doesn't have to steal your mouse and keyboard to get the job done. The same driver scales up to isolated cloud desktop fleets, so you can run many agent sessions in parallel without touching your own machine.
Trying it takes minutes: install the driver, point your agent at a simple app, and have it complete a task and confirm the result on screen itself. It's a fast way to see an agent actually operate software end to end, not just describe what it would do.
https://github.com/trycua/cua
Your filing cabinet just became a search bar
Paperless-ngx turns scanned paper into a searchable archive. Every page gets OCR'd automatically, even blurry scans, so a receipt from three years ago is one keyword away instead of a drawer away.
The unusual part: it doesn't just store the text, it also suggests tags, dates and document types as it ingests each file, so the archive organizes itself instead of waiting on you.
It's fully open source and self-hosted, written in Python. Spin it up with
https://github.com/paperless-ngx/paperless-ngx
Paperless-ngx turns scanned paper into a searchable archive. Every page gets OCR'd automatically, even blurry scans, so a receipt from three years ago is one keyword away instead of a drawer away.
The unusual part: it doesn't just store the text, it also suggests tags, dates and document types as it ingests each file, so the archive organizes itself instead of waiting on you.
It's fully open source and self-hosted, written in Python. Spin it up with
docker compose and a single install script gets you a running instance on your own server in minutes — no cloud, no subscription, your documents never leave your hardware.https://github.com/paperless-ngx/paperless-ngx
⚡ AI News
Anthropic delays IPO to November, eyes $2T — Anthropic pushed its IPO from October to November to show strong Q3 numbers, targeting a $2 trillion valuation and up to $100B raised.
OpenAI: no safe path yet to full RSI, xAI eyes 2027 — OpenAI says it can't yet safely reach full recursive self-improvement, while xAI targets full automation by 2027.
US and China open AI talks ahead of Trump-Xi summit — Bessent and He Lifeng opened New York talks on AI guardrails, tariffs and minerals before the Trump-Xi summit.
Anthropic delays IPO to November, eyes $2T — Anthropic pushed its IPO from October to November to show strong Q3 numbers, targeting a $2 trillion valuation and up to $100B raised.
OpenAI: no safe path yet to full RSI, xAI eyes 2027 — OpenAI says it can't yet safely reach full recursive self-improvement, while xAI targets full automation by 2027.
US and China open AI talks ahead of Trump-Xi summit — Bessent and He Lifeng opened New York talks on AI guardrails, tariffs and minerals before the Trump-Xi summit.
Claude just got ten Wall Street analyst jobs — for free
Comps, precedent transactions, LBO models, GL reconciliations, IC memos — normally hours of an analyst's week. This repo packages ten of those workflows as ready-made Claude agents, from a Pitch Agent that builds a full branded deck to a GL Reconciler that hunts ledger breaks.
Every agent is self-contained, bundling the skills and data connectors it needs, and ships two ways from one source: as a Claude Cowork plugin, or as a template for the Claude Managed Agents API behind your own orchestration layer. Install one, and slash commands like
It's open source and free. Add the marketplace with
https://github.com/anthropics/financial-services
Comps, precedent transactions, LBO models, GL reconciliations, IC memos — normally hours of an analyst's week. This repo packages ten of those workflows as ready-made Claude agents, from a Pitch Agent that builds a full branded deck to a GL Reconciler that hunts ledger breaks.
Every agent is self-contained, bundling the skills and data connectors it needs, and ships two ways from one source: as a Claude Cowork plugin, or as a template for the Claude Managed Agents API behind your own orchestration layer. Install one, and slash commands like
/comps, /dcf, /earnings appear in your session.It's open source and free. Add the marketplace with
claude plugin marketplace add anthropics/financial-services, then install the agents or vertical bundles you need.https://github.com/anthropics/financial-services
Let AI design your UI without letting it run wild
Ask a model to generate a UI and it improvises everything — random layouts, invented components, no guarantees. json-render fixes that by making AI pick only from a catalog of components you define, so the output is guardrailed instead of guessed.
Define a schema once and every AI response matches it, every time, output validated against your own component and action definitions rather than free-formed HTML or JSX. Specs stream in and render progressively as the model responds, so UIs build up live instead of appearing all at once.
The same catalog renders across React, Vue, Svelte, Solid, and React Native, with 36 pre-built shadcn/ui components ready to drop in. AI designs the layout, you keep full control of what it's allowed to build.
https://github.com/vercel-labs/json-render
Ask a model to generate a UI and it improvises everything — random layouts, invented components, no guarantees. json-render fixes that by making AI pick only from a catalog of components you define, so the output is guardrailed instead of guessed.
Define a schema once and every AI response matches it, every time, output validated against your own component and action definitions rather than free-formed HTML or JSX. Specs stream in and render progressively as the model responds, so UIs build up live instead of appearing all at once.
The same catalog renders across React, Vue, Svelte, Solid, and React Native, with 36 pre-built shadcn/ui components ready to drop in. AI designs the layout, you keep full control of what it's allowed to build.
https://github.com/vercel-labs/json-render
⚡ AI News
Amazon blocks Meta's Muse AI shopping agent — Amazon cut Meta's Muse agent off checkout on Amazon.com, citing undisclosed access and stored login credentials.
OpenAI's ad pixel tracks users across websites — OpenAI's __obi cookie links ChatGPT accounts to browsing on 12+ partner sites, even without marketing consent.
Google's AX agent orchestrator hits v0.3.0 — Google's open-source AX orchestrator reached v0.3.0 and topped Hacker News, moving agent state to Redis Streams.
Amazon blocks Meta's Muse AI shopping agent — Amazon cut Meta's Muse agent off checkout on Amazon.com, citing undisclosed access and stored login credentials.
OpenAI's ad pixel tracks users across websites — OpenAI's __obi cookie links ChatGPT accounts to browsing on 12+ partner sites, even without marketing consent.
Google's AX agent orchestrator hits v0.3.0 — Google's open-source AX orchestrator reached v0.3.0 and topped Hacker News, moving agent state to Redis Streams.
Catch spyware before it catches your sources
MVT (Mobile Verification Toolkit) is a forensics kit for Android and iOS built by Amnesty International's Security Lab, born out of the Pegasus Project investigation. It scans a device backup for the traces that stealthy spyware leaves behind: rogue processes, planted files, suspicious network activity.
What sets it apart is the intelligence behind the scan: MVT checks devices against public indicators of compromise from real, documented spyware campaigns, not generic heuristics. It's a command-line tool for people who understand digital forensics, not a one-tap "am I safe" app, and it says so plainly.
Install it with
https://github.com/mvt-project/mvt
MVT (Mobile Verification Toolkit) is a forensics kit for Android and iOS built by Amnesty International's Security Lab, born out of the Pegasus Project investigation. It scans a device backup for the traces that stealthy spyware leaves behind: rogue processes, planted files, suspicious network activity.
What sets it apart is the intelligence behind the scan: MVT checks devices against public indicators of compromise from real, documented spyware campaigns, not generic heuristics. It's a command-line tool for people who understand digital forensics, not a one-tap "am I safe" app, and it says so plainly.
Install it with
pip3 install mvt (or via uv tool install mvt), then point mvt-ios or mvt-android at a device backup to get started. It's written in Python and fully open source.https://github.com/mvt-project/mvt
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Quit Claude Code mid-task, open Codex, and it already knows what happened
ai-memory gives coding agents a shared long-term memory that survives switching tools, machines, or people. Twenty-plus harnesses — Claude Code, Codex, Cursor, Gemini CLI, and more — read and write the same store, and every handoff is typed, owned, and claimed exactly once, so the next agent picks up where the last one stopped.
It's built on a git-backed wiki of plain markdown, not a vector database or a binary blob. Lifecycle hooks capture prompts and decisions silently, then turn them into readable pages you can grep, edit, or open in Obsidian — the database is just a rebuildable index. Capture and search run with zero LLM calls by default.
One self-contained Rust binary. Point it at a project and it's ready; point a whole team at one server and knowledge is shared automatically.
https://github.com/akitaonrails/ai-memory
ai-memory gives coding agents a shared long-term memory that survives switching tools, machines, or people. Twenty-plus harnesses — Claude Code, Codex, Cursor, Gemini CLI, and more — read and write the same store, and every handoff is typed, owned, and claimed exactly once, so the next agent picks up where the last one stopped.
It's built on a git-backed wiki of plain markdown, not a vector database or a binary blob. Lifecycle hooks capture prompts and decisions silently, then turn them into readable pages you can grep, edit, or open in Obsidian — the database is just a rebuildable index. Capture and search run with zero LLM calls by default.
One self-contained Rust binary. Point it at a project and it's ready; point a whole team at one server and knowledge is shared automatically.
https://github.com/akitaonrails/ai-memory
⚡ AI News
Anthropic weighs rushing new model to counter GPT-6 Astra — Reuters: Anthropic may accelerate a new model as OpenAI's Astra grabs 13% of enterprise AI spend versus Claude's 8%, days after Amodei urged a slowdown.
Bessent: OpenAI managers, not agents, own Hugging Face hack — US Treasury Secretary Scott Bessent said OpenAI's management bears responsibility for the July agentic breach of Hugging Face, not the AI agents involved.
SoftBank seeks record $11B junk bond sale for OpenAI bet — SoftBank is selling over $11B in high-yield bonds to fund its $10B tranche of OpenAI's follow-on investment closing October 1.
Anthropic weighs rushing new model to counter GPT-6 Astra — Reuters: Anthropic may accelerate a new model as OpenAI's Astra grabs 13% of enterprise AI spend versus Claude's 8%, days after Amodei urged a slowdown.
Bessent: OpenAI managers, not agents, own Hugging Face hack — US Treasury Secretary Scott Bessent said OpenAI's management bears responsibility for the July agentic breach of Hugging Face, not the AI agents involved.
SoftBank seeks record $11B junk bond sale for OpenAI bet — SoftBank is selling over $11B in high-yield bonds to fund its $10B tranche of OpenAI's follow-on investment closing October 1.
Your AI coding agent doesn't need your API keys
Coder gives every developer, and every AI agent working for them, its own secure workspace — defined in Terraform, spun up in seconds, and torn down automatically when nobody's using it. No more manual onboarding, no more idle EC2 instances quietly burning budget.
The interesting part is credential handling. Agent loops run in the control plane on your own infrastructure, so no LLM keys ever sit inside a workspace. Every action an agent takes is still logged under your identity, and you can bring any model — Anthropic, OpenAI, Google, Bedrock, or something self-hosted.
It's a single Go binary. Install it, run
github.com/coder/coder
Coder gives every developer, and every AI agent working for them, its own secure workspace — defined in Terraform, spun up in seconds, and torn down automatically when nobody's using it. No more manual onboarding, no more idle EC2 instances quietly burning budget.
The interesting part is credential handling. Agent loops run in the control plane on your own infrastructure, so no LLM keys ever sit inside a workspace. Every action an agent takes is still logged under your identity, and you can bring any model — Anthropic, OpenAI, Google, Bedrock, or something self-hosted.
It's a single Go binary. Install it, run
coder server, open localhost:3000, and you have a template and a running workspace before the coffee's done.github.com/coder/coder
Turn hours of footage into clips people actually finish watching
AutoClip reads your video's subtitles, finds the moments worth keeping, scores them, and writes titles for each one. Then it cuts the clips and assembles a highlight reel on its own — no scrubbing through a two-hour podcast by hand.
It works from a local file or a YouTube/Bilibili link, and it's not locked to one AI vendor: run it against OpenAI-compatible APIs, Gemini, Qwen, or your own local model through Ollama or LM Studio. Export presets burn in captions and crop for Shorts, Reels, and Douyin out of the box.
Free and open source under MIT. Grab the desktop app for macOS or Windows, spin it up with Docker for a web UI, or use the CLI — it also speaks MCP, so an agent can drive the whole clipping pipeline for you.
https://github.com/zhouxiaoka/autoclip
AutoClip reads your video's subtitles, finds the moments worth keeping, scores them, and writes titles for each one. Then it cuts the clips and assembles a highlight reel on its own — no scrubbing through a two-hour podcast by hand.
It works from a local file or a YouTube/Bilibili link, and it's not locked to one AI vendor: run it against OpenAI-compatible APIs, Gemini, Qwen, or your own local model through Ollama or LM Studio. Export presets burn in captions and crop for Shorts, Reels, and Douyin out of the box.
Free and open source under MIT. Grab the desktop app for macOS or Windows, spin it up with Docker for a web UI, or use the CLI — it also speaks MCP, so an agent can drive the whole clipping pipeline for you.
https://github.com/zhouxiaoka/autoclip
Graphify vs Supermemory: two "context layers" that solve opposite problems
Both promise to give AI coding assistants like Claude Code, Cursor and Codex more context — but they get there in opposite ways.
Graphify parses your codebase locally with tree-sitter into a queryable knowledge graph — files, docs, SQL schemas, configs, even PDFs. No embeddings, no vector store, no LLM call to build it; every edge is tagged
Supermemory takes the opposite route: a hosted memory API that ingests conversations, auto-extracts facts, builds evolving user profiles, and serves context back in ~50ms while handling contradictions and forgetting. Ships as an API/SDK, MCP server, and plugins for Claude Code, Cursor and Codex; self-hostable too.
They barely compete despite looking like rivals: one maps code you already have, the other remembers what you said.
Graphify vs Supermemory
Both promise to give AI coding assistants like Claude Code, Cursor and Codex more context — but they get there in opposite ways.
Graphify parses your codebase locally with tree-sitter into a queryable knowledge graph — files, docs, SQL schemas, configs, even PDFs. No embeddings, no vector store, no LLM call to build it; every edge is tagged
EXTRACTED or INFERRED. Runs as a /graphify command, install with uv tool install graphifyy — free and open-source.Supermemory takes the opposite route: a hosted memory API that ingests conversations, auto-extracts facts, builds evolving user profiles, and serves context back in ~50ms while handling contradictions and forgetting. Ships as an API/SDK, MCP server, and plugins for Claude Code, Cursor and Codex; self-hostable too.
They barely compete despite looking like rivals: one maps code you already have, the other remembers what you said.
Graphify vs Supermemory
⚡ AI News
OpenAI urges US-led global AI safety standards — OpenAI asked Washington to lead international standards on frontier AI ahead of Altman's UN Security Council briefing.
xAI ships Grok 4.7 with 2.1 trillion parameters — Grok 4.7 packs 2.1 trillion parameters, a 40% jump over Grok 4.6, but trails GPT-6 and Claude on benchmarks.
Meta's Muse AI agent tops US App Store charts — Meta's Muse AI assistant hit #1 on Apple's US App Store, sending Meta shares up more than 11% in a day.
OpenAI urges US-led global AI safety standards — OpenAI asked Washington to lead international standards on frontier AI ahead of Altman's UN Security Council briefing.
xAI ships Grok 4.7 with 2.1 trillion parameters — Grok 4.7 packs 2.1 trillion parameters, a 40% jump over Grok 4.6, but trails GPT-6 and Claude on benchmarks.
Meta's Muse AI agent tops US App Store charts — Meta's Muse AI assistant hit #1 on Apple's US App Store, sending Meta shares up more than 11% in a day.
One token, 3,000+ paid tools your agent can finally call
Backlink data, company enrichment, trend tracking, ad platforms — the APIs that actually get work done usually sit behind a subscription nobody buys for one run, a signup wall, or no public access at all. Treg puts them all behind a single base URL and token, priced per call from a cent, no provider signup needed.
Search for the job, not the vendor: describe what you need, read the price, call it. Your own team's keys, skills and CLIs register the same way, so every teammate's agent can use them without the credential ever leaving the server.
Self-host it or use the hosted instance. The CLI installs in one line and gets an agent calling a live endpoint in under a minute, no key required to start.
https://github.com/superdesigndev/treg
Backlink data, company enrichment, trend tracking, ad platforms — the APIs that actually get work done usually sit behind a subscription nobody buys for one run, a signup wall, or no public access at all. Treg puts them all behind a single base URL and token, priced per call from a cent, no provider signup needed.
Search for the job, not the vendor: describe what you need, read the price, call it. Your own team's keys, skills and CLIs register the same way, so every teammate's agent can use them without the credential ever leaving the server.
Self-host it or use the hosted instance. The CLI installs in one line and gets an agent calling a live endpoint in under a minute, no key required to start.
https://github.com/superdesigndev/treg