π° We May Be Building Satellite Constellations Too Large for Earthβs Orbit
A new analysis suggests that some satellite megaconstellations could cross a dangerous threshold where collisions create debris faster than Earthβs atmosphere can remove it β potentially triggering a runaway increase in space junk.
The study introduces the idea of a βcritical sizeβ for a satellite constellation. Above that point, even if individual satellites follow good disposal practices and actively avoid collisions, the constellation as a whole may still generate an unstable debris environment. The model found that several planned, partially deployed and existing constellations exceed that threshold under some assumptions.
The scale of what is being proposed is enormous. The paper notes that the number of active satellites in low-Earth orbit increased by nearly 12,000 in just five years, while applications submitted to the U.S. FCC in 2026 included proposed constellations totaling more than 1.2 million satellites. That would be over 78 times the current operational satellite population cited by the study.
The feared endpoint is related to the Kessler syndrome: one collision produces fragments, those fragments cause more collisions, and eventually parts of low-Earth orbit become increasingly difficult to use safely.
The important caveat: this is a modelling study and currently a preprint, not peer-reviewed research. It does not predict that a catastrophic debris cascade is about to happen tomorrow. But it raises a bigger question: should regulators evaluate satellites one by one β or the cumulative risk of entire constellations?
Space may be enormous. Useful orbit around Earth is not.
#Space #Satellites #SpaceDebris #Astronomy #SpaceTech #Science
https://arxiv.org/abs/2607.29644
A new analysis suggests that some satellite megaconstellations could cross a dangerous threshold where collisions create debris faster than Earthβs atmosphere can remove it β potentially triggering a runaway increase in space junk.
The study introduces the idea of a βcritical sizeβ for a satellite constellation. Above that point, even if individual satellites follow good disposal practices and actively avoid collisions, the constellation as a whole may still generate an unstable debris environment. The model found that several planned, partially deployed and existing constellations exceed that threshold under some assumptions.
The scale of what is being proposed is enormous. The paper notes that the number of active satellites in low-Earth orbit increased by nearly 12,000 in just five years, while applications submitted to the U.S. FCC in 2026 included proposed constellations totaling more than 1.2 million satellites. That would be over 78 times the current operational satellite population cited by the study.
The feared endpoint is related to the Kessler syndrome: one collision produces fragments, those fragments cause more collisions, and eventually parts of low-Earth orbit become increasingly difficult to use safely.
The important caveat: this is a modelling study and currently a preprint, not peer-reviewed research. It does not predict that a catastrophic debris cascade is about to happen tomorrow. But it raises a bigger question: should regulators evaluate satellites one by one β or the cumulative risk of entire constellations?
Space may be enormous. Useful orbit around Earth is not.
#Space #Satellites #SpaceDebris #Astronomy #SpaceTech #Science
https://arxiv.org/abs/2607.29644
arXiv.org
Critical Sizes of Satellite Constellations
The precipitous growth of commercial space activity, largely from the development of satellite constellations, threatens to produce a runaway orbital debris population. National regulators are...
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π΄ A Rock From Mars Just Filled a 2-Billion-Year Hole in the Planetβs History
Scientists have dated an unusual Martian meteorite to 1.273 billion years old β placing it almost exactly inside a huge missing chapter in our geological record of Mars.
The meteorite, called NWA 13441, was discovered in Algeria in 2019. Most Martian volcanic meteorites of its type are either younger than about 600 million years or around 2.4 billion years old. Until now, researchers had essentially no samples from the enormous interval between them.
But its age may not even be the strangest part. The rockβs neodymium isotopes suggest that the magma it formed from came from a portion of the Martian mantle that had remained remarkably untouched since the earliest days of the Solar System. Mars formed very quickly and, unlike Earth, has no active plate tectonics constantly remixing its interior β potentially allowing ancient chemical reservoirs to survive for billions of years.
In other words, a small rock blasted off Mars by an impact and eventually found in the Sahara may contain a chemical fingerprint preserved from almost the beginning of the planet itself.
How much of Marsβs earliest history could still be locked inside rocks already lying somewhere on Earth?
#Mars #Space #Meteorite #PlanetaryScience #Geology #Science
https://doi.org/10.1016/j.gca.2026.06.035
Scientists have dated an unusual Martian meteorite to 1.273 billion years old β placing it almost exactly inside a huge missing chapter in our geological record of Mars.
The meteorite, called NWA 13441, was discovered in Algeria in 2019. Most Martian volcanic meteorites of its type are either younger than about 600 million years or around 2.4 billion years old. Until now, researchers had essentially no samples from the enormous interval between them.
But its age may not even be the strangest part. The rockβs neodymium isotopes suggest that the magma it formed from came from a portion of the Martian mantle that had remained remarkably untouched since the earliest days of the Solar System. Mars formed very quickly and, unlike Earth, has no active plate tectonics constantly remixing its interior β potentially allowing ancient chemical reservoirs to survive for billions of years.
In other words, a small rock blasted off Mars by an impact and eventually found in the Sahara may contain a chemical fingerprint preserved from almost the beginning of the planet itself.
How much of Marsβs earliest history could still be locked inside rocks already lying somewhere on Earth?
#Mars #Space #Meteorite #PlanetaryScience #Geology #Science
https://doi.org/10.1016/j.gca.2026.06.035
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ποΈ Scientists Have Mapped the Wiring Behind Human High-Resolution Vision
Researchers have created the first complete cell-by-cell and synapse-level wiring map of the human fovea β the pinhead-sized region of the retina that lets us read, recognize faces and see fine detail in color.
The team reconstructed roughly 3,000 neurons and more than 300,000 connections, tracing how signals move through this tiny patch of nervous tissue. What they found was unexpectedly elegant: while much of the retina uses many overlapping pathways, the human fovea funnels visual information through just three major circuits.
That streamlined architecture may be one reason human central vision is so precise. The researchers describe it as more like an expressway than a maze of side streets β sacrificing redundancy for speed and efficiency.
The fovea is technically part of the central nervous system, which makes this the first complete connectivity map of a human CNS structure at this level of detail. Beyond basic neuroscience, the map could become a reference for treatments aimed at retinal diseases that destroy central vision.
We often talk about the brain as the organ that βsees.β But the first stage of high-resolution vision may already be doing far more sophisticated processing than we realized.
#Neuroscience #Vision #HumanBrain #Retina #Connectome #Science
https://www.pnas.org/doi/10.1073/pnas.2603286123
Researchers have created the first complete cell-by-cell and synapse-level wiring map of the human fovea β the pinhead-sized region of the retina that lets us read, recognize faces and see fine detail in color.
The team reconstructed roughly 3,000 neurons and more than 300,000 connections, tracing how signals move through this tiny patch of nervous tissue. What they found was unexpectedly elegant: while much of the retina uses many overlapping pathways, the human fovea funnels visual information through just three major circuits.
That streamlined architecture may be one reason human central vision is so precise. The researchers describe it as more like an expressway than a maze of side streets β sacrificing redundancy for speed and efficiency.
The fovea is technically part of the central nervous system, which makes this the first complete connectivity map of a human CNS structure at this level of detail. Beyond basic neuroscience, the map could become a reference for treatments aimed at retinal diseases that destroy central vision.
We often talk about the brain as the organ that βsees.β But the first stage of high-resolution vision may already be doing far more sophisticated processing than we realized.
#Neuroscience #Vision #HumanBrain #Retina #Connectome #Science
https://www.pnas.org/doi/10.1073/pnas.2603286123
PNAS
Approaching a connectome of the human foveal retina
The foveal retina is a unique primate specialization and a promising target for the first connectome of a human central nervous system structure. I...
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βοΈ Physicists May Have Finally Found Matter Made Mostly of Force
For nearly 50 years, physicists have searched for a bizarre particle predicted by quantum chromodynamics: the glueball.
Ordinary matter is built from quarks. Gluons are the particles that carry the strong nuclear force and βglueβ quarks together inside protons and neutrons. But because gluons also interact with each other, theory predicts that they should be able to bind together β creating a particle with no ordinary valence quarks at its core.
Now the BESIII experiment in China says X(2370), a particle first detected in 2011, finally fits the bill. Using a dataset of roughly 10 billion J/Ο particles, researchers have gradually established its mass, spin and parity, unusual decay patterns, and now its flavor-singlet behavior. Taken together, the team argues that these properties are best explained if a pseudoscalar glueball is the dominant component of X(2370).
That distinction matters: scientists are not yet claiming X(2370) is a perfectly pure ball of gluons. Quantum particles can mix with other states, and the newest analysis is currently a preprint awaiting peer review. But independent physicists describe it as the strongest glueball evidence produced in decades.
If confirmed, it would be an extraordinary demonstration of one of QCDβs strangest predictions: the particles responsible for holding matter together can apparently bind together themselves.
Matter made mostly from the force that binds matter.
Physics occasionally writes its own headlines.
#Physics #ParticlePhysics #QuantumPhysics #QCD #Glueball #Science
https://english.ihep.cas.cn/nw/han/y26/202608/t20260804_1186878.html
For nearly 50 years, physicists have searched for a bizarre particle predicted by quantum chromodynamics: the glueball.
Ordinary matter is built from quarks. Gluons are the particles that carry the strong nuclear force and βglueβ quarks together inside protons and neutrons. But because gluons also interact with each other, theory predicts that they should be able to bind together β creating a particle with no ordinary valence quarks at its core.
Now the BESIII experiment in China says X(2370), a particle first detected in 2011, finally fits the bill. Using a dataset of roughly 10 billion J/Ο particles, researchers have gradually established its mass, spin and parity, unusual decay patterns, and now its flavor-singlet behavior. Taken together, the team argues that these properties are best explained if a pseudoscalar glueball is the dominant component of X(2370).
That distinction matters: scientists are not yet claiming X(2370) is a perfectly pure ball of gluons. Quantum particles can mix with other states, and the newest analysis is currently a preprint awaiting peer review. But independent physicists describe it as the strongest glueball evidence produced in decades.
If confirmed, it would be an extraordinary demonstration of one of QCDβs strangest predictions: the particles responsible for holding matter together can apparently bind together themselves.
Matter made mostly from the force that binds matter.
Physics occasionally writes its own headlines.
#Physics #ParticlePhysics #QuantumPhysics #QCD #Glueball #Science
https://english.ihep.cas.cn/nw/han/y26/202608/t20260804_1186878.html
english.ihep.cas.cn
BESIII Experiment Identifies X(2370) as a Glueball Dominated Particle----Institute of High Energy Physics, Chinese Academy of Sciences
lnstitute of Theoretical PhysicsChinese Academy of Sciences
β‘28π8π6π₯3π1
πͺ± Animals Have Been Eating Natureβs βBioplasticβ for Millions of Years
Long before humans invented biodegradable plastics, bacteria were already making their own.
Many microorganisms produce compounds called polyhydroxyalkanoates, or PHAs β natural polyester-like materials that they store inside their cells as reserves of carbon and energy. Scientists had long assumed that breaking down these microbial plastics was essentially a job for microorganisms themselves.
Then researchers studied a very strange animal: Olavius algarvensis, a tiny marine worm with no mouth and no gut. It survives by hosting bacteria beneath its skin and digesting them for nutrition. Some of those bacteria store as much as 42% of their cellular carbon in PHA.
The researchers discovered that the worm produces its own enzyme capable of breaking PHA into smaller molecules it can use. And it is not alone. Related enzymes turned up in more than 66 animal species across nine major animal groups, including sponges, starfish, earthworms and springtails. Laboratory experiments confirmed that enzymes from several distantly related animals really can degrade PHA.
The finding reveals a previously overlooked route through which carbon stored by microbes enters animal food webs β and suggests animals may have been consuming natureβs original bioplastics for hundreds of millions of years.
Humans invented biodegradable plastic.
Evolution apparently invented both the plastic and something to eat it.
#Biology #Evolution #Bioplastic #Ecology #Microbiology #Science
https://www.nature.com/articles/s41559-026-03153-8
Long before humans invented biodegradable plastics, bacteria were already making their own.
Many microorganisms produce compounds called polyhydroxyalkanoates, or PHAs β natural polyester-like materials that they store inside their cells as reserves of carbon and energy. Scientists had long assumed that breaking down these microbial plastics was essentially a job for microorganisms themselves.
Then researchers studied a very strange animal: Olavius algarvensis, a tiny marine worm with no mouth and no gut. It survives by hosting bacteria beneath its skin and digesting them for nutrition. Some of those bacteria store as much as 42% of their cellular carbon in PHA.
The researchers discovered that the worm produces its own enzyme capable of breaking PHA into smaller molecules it can use. And it is not alone. Related enzymes turned up in more than 66 animal species across nine major animal groups, including sponges, starfish, earthworms and springtails. Laboratory experiments confirmed that enzymes from several distantly related animals really can degrade PHA.
The finding reveals a previously overlooked route through which carbon stored by microbes enters animal food webs β and suggests animals may have been consuming natureβs original bioplastics for hundreds of millions of years.
Humans invented biodegradable plastic.
Evolution apparently invented both the plastic and something to eat it.
#Biology #Evolution #Bioplastic #Ecology #Microbiology #Science
https://www.nature.com/articles/s41559-026-03153-8
Nature
Animal degradation of microbial storage polyhydroxyalkanoates
Nature Ecology & Evolution - This study shows that the degradation of microbial storage polyhydroxyalkanoates is not just restricted to microorganisms by finding that some animals also have the...
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π Astronomers Found the Remains of a Galaxy the Milky Way Ate 12 Billion Years Ago
The Milky Way did not grow up quietly.
Astronomers have found strong evidence that our Galaxy swallowed a substantial dwarf galaxy about 12.3 billion years ago β when the Universe was still very young. The merger happened roughly 1.8 billion years before the better-known GaiaβSausageβEnceladus collision, previously one of the earliest major events firmly traced in the Milky Wayβs history.
The clue came from globular clusters β ancient, densely packed groups of stars that preserve a kind of archaeological record of the Galaxy. Using extremely precise Hubble Space Telescope measurements, researchers identified a third distinct age-and-metallicity sequence among clusters in the inner Milky Way. That sequence points to a separate progenitor galaxy with a stellar mass of about 500 million Suns.
The team named the lost galaxy Low-energy-Kraken-Heracles, or LKH. Most of its stars appear to have been deposited within the inner 6,000 parsecs of the Milky Way, where their original identity has long since been erased by billions of years of mixing.
In other words, parts of the night sky above us may be made from the remains of another galaxy that disappeared before Earth existed.
Galaxies do not simply form. They assemble themselves by consuming one another.
#MilkyWay #Astronomy #Hubble #Galaxies #Cosmology #Science
https://www.nature.com/articles/s41550-026-02931-5
The Milky Way did not grow up quietly.
Astronomers have found strong evidence that our Galaxy swallowed a substantial dwarf galaxy about 12.3 billion years ago β when the Universe was still very young. The merger happened roughly 1.8 billion years before the better-known GaiaβSausageβEnceladus collision, previously one of the earliest major events firmly traced in the Milky Wayβs history.
The clue came from globular clusters β ancient, densely packed groups of stars that preserve a kind of archaeological record of the Galaxy. Using extremely precise Hubble Space Telescope measurements, researchers identified a third distinct age-and-metallicity sequence among clusters in the inner Milky Way. That sequence points to a separate progenitor galaxy with a stellar mass of about 500 million Suns.
The team named the lost galaxy Low-energy-Kraken-Heracles, or LKH. Most of its stars appear to have been deposited within the inner 6,000 parsecs of the Milky Way, where their original identity has long since been erased by billions of years of mixing.
In other words, parts of the night sky above us may be made from the remains of another galaxy that disappeared before Earth existed.
Galaxies do not simply form. They assemble themselves by consuming one another.
#MilkyWay #Astronomy #Hubble #Galaxies #Cosmology #Science
https://www.nature.com/articles/s41550-026-02931-5
Nature
Evidence of a massive accretion event 1.8 billion years before the Gaia-Sausage-Enceladus merger
Nature Astronomy - By studying the dynamical properties, age and metallicity of globular clusters in the inner Galaxy, the authors found evidence of a massive dwarf galaxy that was accreted by the...
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Forwarded from Pavel Durov (Pavel Durov)
If the application is approved by ICANN, a billion Telegram users could get their own second-level domains.
Users would be able to set up their interactive websites hosted by Telegram β just by typing one prompt
Please open Telegram to view this post
VIEW IN TELEGRAM
π₯52π23π8π7
π Scientists May Have Seen βEmptyβ Space Bend Light
Almost 90 years ago, quantum theory made a bizarre prediction: a perfect vacuum is not truly empty. Under an unimaginably strong magnetic field, empty space itself should behave a little like a transparent material β changing the way light passes through it.
Now astronomers may finally have seen the effect in nature.
Researchers studied 1E 1547.0β5408, a magnetar β an ultra-dense neutron star with a surface magnetic field above 100 trillion gauss. Using NASAβs IXPE X-ray telescope together with NICER and Australiaβs Parkes/Murriyang radio telescope, the team measured extraordinarily polarized X-rays: about 65% at 2 keV, rising to nearly 80% during parts of the starβs rotation.
Ordinary models struggled to reproduce what they saw. But when the researchers included vacuum birefringence β a prediction of quantum electrodynamics in which extreme magnetic fields make the quantum vacuum refract different polarizations of light differently β the observations fell naturally into place.
The idea goes back to work by Werner Heisenberg and Hans Euler in the 1930s. In modern quantum field theory, even a vacuum contains fluctuating quantum fields, and extreme magnetic fields can alter how photons propagate through them.
This is not yet considered a definitive detection. The researchers say more observations and improved simulations are needed to rule out competing explanations.
But if confirmed, the result would turn one of the strangest properties of quantum theory into something astronomers can actually observe across the Galaxy.
Empty space, apparently, may not be very empty at all.
#Physics #QuantumPhysics #Magnetar #Astronomy #QED #Science
https://www.nature.com/articles/s41586-026-10859-z
Almost 90 years ago, quantum theory made a bizarre prediction: a perfect vacuum is not truly empty. Under an unimaginably strong magnetic field, empty space itself should behave a little like a transparent material β changing the way light passes through it.
Now astronomers may finally have seen the effect in nature.
Researchers studied 1E 1547.0β5408, a magnetar β an ultra-dense neutron star with a surface magnetic field above 100 trillion gauss. Using NASAβs IXPE X-ray telescope together with NICER and Australiaβs Parkes/Murriyang radio telescope, the team measured extraordinarily polarized X-rays: about 65% at 2 keV, rising to nearly 80% during parts of the starβs rotation.
Ordinary models struggled to reproduce what they saw. But when the researchers included vacuum birefringence β a prediction of quantum electrodynamics in which extreme magnetic fields make the quantum vacuum refract different polarizations of light differently β the observations fell naturally into place.
The idea goes back to work by Werner Heisenberg and Hans Euler in the 1930s. In modern quantum field theory, even a vacuum contains fluctuating quantum fields, and extreme magnetic fields can alter how photons propagate through them.
This is not yet considered a definitive detection. The researchers say more observations and improved simulations are needed to rule out competing explanations.
But if confirmed, the result would turn one of the strangest properties of quantum theory into something astronomers can actually observe across the Galaxy.
Empty space, apparently, may not be very empty at all.
#Physics #QuantumPhysics #Magnetar #Astronomy #QED #Science
https://www.nature.com/articles/s41586-026-10859-z
Nature
Vacuum birefringence and the polarized X-ray emission from a radio magnetar
Nature - Polarization measurements of the magnetar 1E 1547.0β5408 provide strong evidence that vacuum birefringence shapes X-ray propagation, offering an important observational test of...
π₯28π15π8β‘7
𧬠A Personalized mRNA Cancer Vaccine Has Passed Its Biggest Test Yet
For the first time, a personalized mRNA cancer therapy has succeeded in a Phase 3 clinical trial β the final major testing stage before regulators can consider approval.
The treatment, called intismeran autogene, is not an off-the-shelf vaccine. Doctors sequence each patientβs tumour, identify mutations unique to their cancer, and manufacture an individual mRNA therapy encoding up to 34 of those tumour-specific targets. The goal is essentially to give the immune system a personalized wanted poster for the cancer.
In the trial, 1,137 people with stage IIBβIV melanoma whose tumours had been completely removed received either the personalized mRNA therapy plus the immunotherapy drug pembrolizumab (Keytruda), or pembrolizumab alone. The combination produced statistically significant and clinically meaningful improvements in both recurrence-free survival and distant-metastasis-free survival. No new safety signal was reported.
There is an important caveat: the companies have so far announced only top-line Phase 3 results. They have not yet released the detailed numbers, and it is not yet known whether the treatment ultimately extends overall survival. The therapy also remains investigational and has not been approved.
But the principle is now much harder to dismiss. Instead of finding one cancer vaccine that works for everyone, medicine may be able to manufacture a different vaccine for each individual tumour.
Cancer is personal.
The vaccine might have to be too.
#Cancer #mRNA #Melanoma #Immunotherapy #Biotechnology #Medicine #Science
For the first time, a personalized mRNA cancer therapy has succeeded in a Phase 3 clinical trial β the final major testing stage before regulators can consider approval.
The treatment, called intismeran autogene, is not an off-the-shelf vaccine. Doctors sequence each patientβs tumour, identify mutations unique to their cancer, and manufacture an individual mRNA therapy encoding up to 34 of those tumour-specific targets. The goal is essentially to give the immune system a personalized wanted poster for the cancer.
In the trial, 1,137 people with stage IIBβIV melanoma whose tumours had been completely removed received either the personalized mRNA therapy plus the immunotherapy drug pembrolizumab (Keytruda), or pembrolizumab alone. The combination produced statistically significant and clinically meaningful improvements in both recurrence-free survival and distant-metastasis-free survival. No new safety signal was reported.
There is an important caveat: the companies have so far announced only top-line Phase 3 results. They have not yet released the detailed numbers, and it is not yet known whether the treatment ultimately extends overall survival. The therapy also remains investigational and has not been approved.
But the principle is now much harder to dismiss. Instead of finding one cancer vaccine that works for everyone, medicine may be able to manufacture a different vaccine for each individual tumour.
Cancer is personal.
The vaccine might have to be too.
#Cancer #mRNA #Melanoma #Immunotherapy #Biotechnology #Medicine #Science
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π€ AI Found 15 Cancers That Radiologists Had Missed
A new clinical study offers a glimpse of what medical AI may actually be best at: not replacing doctors, but quietly checking their work.
Researchers deployed an AI system called LiON alongside radiologists reading contrast-enhanced CT scans in routine hospital practice. In a prospective trial involving 10,333 patients, the system flagged 51 liver lesions that had initially been overlooked. Fifteen of them turned out to be malignant.
The alerts were not merely theoretical. They led doctors to amend 37 radiology reports, send 22 cases for multidisciplinary review, and change clinical management for some patients. Before the live trial, LiON had been trained on 6,443 patients and validated retrospectively on another 22,251.
The important nuance is that this was not a randomized trial comparing AI-assisted doctors against doctors alone, and the study did not show that the system improves survival. The researchers themselves say larger prospective comparative studies across different healthcare systems are still needed.
But this is a meaningful step beyond βAI beats doctors on a test set.β
Here, the algorithm sat inside an actual clinical workflow β and found cancers that humans had missed.
Perhaps the most useful medical AI will not be the doctor in the room.
It will be the second pair of eyes that never gets tired.
#AI #Medicine #Cancer #Radiology #MedicalAI #Science
https://www.nature.com/articles/s41591-026-04589-yβ
A new clinical study offers a glimpse of what medical AI may actually be best at: not replacing doctors, but quietly checking their work.
Researchers deployed an AI system called LiON alongside radiologists reading contrast-enhanced CT scans in routine hospital practice. In a prospective trial involving 10,333 patients, the system flagged 51 liver lesions that had initially been overlooked. Fifteen of them turned out to be malignant.
The alerts were not merely theoretical. They led doctors to amend 37 radiology reports, send 22 cases for multidisciplinary review, and change clinical management for some patients. Before the live trial, LiON had been trained on 6,443 patients and validated retrospectively on another 22,251.
The important nuance is that this was not a randomized trial comparing AI-assisted doctors against doctors alone, and the study did not show that the system improves survival. The researchers themselves say larger prospective comparative studies across different healthcare systems are still needed.
But this is a meaningful step beyond βAI beats doctors on a test set.β
Here, the algorithm sat inside an actual clinical workflow β and found cancers that humans had missed.
Perhaps the most useful medical AI will not be the doctor in the room.
It will be the second pair of eyes that never gets tired.
#AI #Medicine #Cancer #Radiology #MedicalAI #Science
https://www.nature.com/articles/s41591-026-04589-yβ
Nature
Large-scale AI-guided liver malignancy diagnosis: multicenter study and a single-arm trial
Nature Medicine - Liver DiagnOsis Network (LiON), a contrast-enhanced-computed tomography-based AI system that supports flexible multiphase processing, clinical data integration and...
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π§ Singapore Just Opened a Data Center Powered by Living Human Neurons
This sounds like science fiction, but it went live on July 16.
Australian startup Cortical Labs, together with the National University of Singapore and data-center operator DayOne, has launched a biological computing facility where part of the processing is performed not by GPUs β but by living human neurons grown in a lab.
Inside are 20 CL1 biological computers. Each contains at least 200,000 neurons grown on a silicon chip covered with electrodes. The neurons originate from human blood cells that are reprogrammed into stem cells and then differentiated into neurons.
And yes, the computers have to be fed.
Every three days, technicians supply the cells with sugar, micronutrients and pH buffers, while a life-support system regulates oxygen, nitrogen and COβ.
The strange part is that these neurons can actually learn.
Cortical Labsβ earlier DishBrain experiment showed human and mouse neurons learning to play Pong, with measurable learning appearing within just minutes. Earlier this year, developer Sean Cole connected around 200,000 human neurons to DOOM β allowing them to navigate the game and shoot at enemies.
Biology is nowhere near silicon in raw speed. But it has another advantage: efficiency.
A CL1 consumes around 30 watts. An NVIDIA H100 SXM can draw up to 700 W, while an eight-H100 server may consume roughly 10 kW including supporting hardware.
Cortical Labs also argues that biological neural networks may learn from far smaller datasets β closer to how humans adapt from limited experience.
Access to one CL1 currently costs about $2,200 per month. Cortical Labs already operates 120 units in Melbourne with around 20 paying customers, and Singapore could eventually expand to 1,000 biological computers.
So no, neurons arenβt replacing GPUs tomorrow.
But we have officially reached the stage where a data center needs electricity, an internet connection⦠and food.
Cyberpunk is becoming an engineering discipline.
#Biocomputing #Neuroscience #AI #DataCenters #CorticalLabs
https://www.straitstimes.com/tech/forget-silicon-chip-servers-singapores-newest-data-centre-needs-to-be-fed
This sounds like science fiction, but it went live on July 16.
Australian startup Cortical Labs, together with the National University of Singapore and data-center operator DayOne, has launched a biological computing facility where part of the processing is performed not by GPUs β but by living human neurons grown in a lab.
Inside are 20 CL1 biological computers. Each contains at least 200,000 neurons grown on a silicon chip covered with electrodes. The neurons originate from human blood cells that are reprogrammed into stem cells and then differentiated into neurons.
And yes, the computers have to be fed.
Every three days, technicians supply the cells with sugar, micronutrients and pH buffers, while a life-support system regulates oxygen, nitrogen and COβ.
The strange part is that these neurons can actually learn.
Cortical Labsβ earlier DishBrain experiment showed human and mouse neurons learning to play Pong, with measurable learning appearing within just minutes. Earlier this year, developer Sean Cole connected around 200,000 human neurons to DOOM β allowing them to navigate the game and shoot at enemies.
Biology is nowhere near silicon in raw speed. But it has another advantage: efficiency.
A CL1 consumes around 30 watts. An NVIDIA H100 SXM can draw up to 700 W, while an eight-H100 server may consume roughly 10 kW including supporting hardware.
Cortical Labs also argues that biological neural networks may learn from far smaller datasets β closer to how humans adapt from limited experience.
Access to one CL1 currently costs about $2,200 per month. Cortical Labs already operates 120 units in Melbourne with around 20 paying customers, and Singapore could eventually expand to 1,000 biological computers.
So no, neurons arenβt replacing GPUs tomorrow.
But we have officially reached the stage where a data center needs electricity, an internet connection⦠and food.
Cyberpunk is becoming an engineering discipline.
#Biocomputing #Neuroscience #AI #DataCenters #CorticalLabs
https://www.straitstimes.com/tech/forget-silicon-chip-servers-singapores-newest-data-centre-needs-to-be-fed
The Straits Times
Forget silicon chip servers, Singaporeβs newest data centre needs to be fed
Singaporeβs first biological data centre uses lab-grown brain cells for energy-efficient computing, ideal for robotics and cybersecurity with limited data needs. Read more at straitstimes.com. Read more at straitstimes.com.
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π₯ CERN Just Created a Tiny Version of the Early Universe
Physicists at the Large Hadron Collider have recreated the strange state of matter that filled the Universe shortly after the Big Bang β using atomic nuclei much smaller than researchers once thought would be sufficient.
The ALICE experiment smashed oxygen-16 and neon-20 nuclei together at enormous energies. The collisions produced evidence of collective hydrodynamic flow consistent with tiny droplets of quarkβgluon plasma β the ultra-hot state in which quarks and gluons are no longer confined inside protons and neutrons.
But the most elegant part came afterward. The particles emerging from the miniature fireballs still carried information about the shape of the nuclei that created them. Oxygen produced a more rounded flow pattern, while neon generated a distinctly elongated signal β reflecting its predicted bowling-pin-like nuclear shape.
That means the same experiment can probe two extremes at once: matter as it behaved during the Universeβs first microseconds, and the tiny internal geometry of atomic nuclei.
Next, researchers want to go smaller still β potentially testing helium nuclei to discover just how tiny a system can be while still behaving like a liquid made of free quarks and gluons.
The Universe once existed in this state everywhere.
At CERN, it now survives for only a fraction of a fraction of a second.
#CERN #Physics #BigBang #QuarkGluonPlasma #ParticlePhysics #Science
https://journals.aps.org/prl/abstract/10.1103/gymp-vp87β
Physicists at the Large Hadron Collider have recreated the strange state of matter that filled the Universe shortly after the Big Bang β using atomic nuclei much smaller than researchers once thought would be sufficient.
The ALICE experiment smashed oxygen-16 and neon-20 nuclei together at enormous energies. The collisions produced evidence of collective hydrodynamic flow consistent with tiny droplets of quarkβgluon plasma β the ultra-hot state in which quarks and gluons are no longer confined inside protons and neutrons.
But the most elegant part came afterward. The particles emerging from the miniature fireballs still carried information about the shape of the nuclei that created them. Oxygen produced a more rounded flow pattern, while neon generated a distinctly elongated signal β reflecting its predicted bowling-pin-like nuclear shape.
That means the same experiment can probe two extremes at once: matter as it behaved during the Universeβs first microseconds, and the tiny internal geometry of atomic nuclei.
Next, researchers want to go smaller still β potentially testing helium nuclei to discover just how tiny a system can be while still behaving like a liquid made of free quarks and gluons.
The Universe once existed in this state everywhere.
At CERN, it now survives for only a fraction of a fraction of a second.
#CERN #Physics #BigBang #QuarkGluonPlasma #ParticlePhysics #Science
https://journals.aps.org/prl/abstract/10.1103/gymp-vp87β
Physical Review Letters
Evidence of Nuclear Geometry-Driven Anisotropic Flow in $\mathrm{O}+\mathrm{O}$ and $\mathrm{Ne}+\mathrm{Ne}$ Collisions at $\β¦
Light-ion collisions at the LHC reveal collective hydrodynamic flow with a larger elliptic flow in central Ne-Ne collisions than in OO collisions that might be due to the bowling-pin nuclear shape of ${}^{20}$Ne.
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π§ Depression May Disrupt the Adult Brainβs Ability to Make New Neurons
For decades, scientists have suspected that depression may interfere with neurogenesis β the formation of new neurons in the adult hippocampus. Most of the strongest evidence, however, came from animal studies.
Now researchers have found evidence of the same process directly in human brains.
The team analyzed nearly 500,000 individual cell nuclei from hippocampal tissue donated by people with major depressive disorder and people without psychiatric illness. Using single-cell gene sequencing, chromatin analysis, spatial transcriptomics and protein measurements, they reconstructed what is effectively a molecular atlas of the hippocampus.
They found a lineage of cells consistent with ongoing adult neurogenesis β but in people with depression, that developmental process appeared to stall before new neurons fully matured. The surrounding hippocampal circuitry also showed signs of inflammation, cellular stress, disrupted synaptic plasticity, altered metabolism and an imbalance between excitatory and inhibitory signaling.
The finding could help explain something particularly characteristic of depression: the tendency for negative memories and experiences to dominate. New hippocampal neurons are thought to contribute to pattern separation β our ability to distinguish a new experience from similar memories in the past.
There is an important caveat: this study shows an association in post-mortem human brains. It does not prove that reduced neurogenesis causes depression, nor does it mean simply increasing neuron production would cure it.
But it moves one long-standing theory of depression from animal experiments much closer to human biology.
Depression may not simply change how neurons communicate.
It may change how the brain renews itself.
#Neuroscience #Depression #Brain #Neurogenesis #MentalHealth #Science
https://www.nature.com/articles/s41591-026-04571-8
For decades, scientists have suspected that depression may interfere with neurogenesis β the formation of new neurons in the adult hippocampus. Most of the strongest evidence, however, came from animal studies.
Now researchers have found evidence of the same process directly in human brains.
The team analyzed nearly 500,000 individual cell nuclei from hippocampal tissue donated by people with major depressive disorder and people without psychiatric illness. Using single-cell gene sequencing, chromatin analysis, spatial transcriptomics and protein measurements, they reconstructed what is effectively a molecular atlas of the hippocampus.
They found a lineage of cells consistent with ongoing adult neurogenesis β but in people with depression, that developmental process appeared to stall before new neurons fully matured. The surrounding hippocampal circuitry also showed signs of inflammation, cellular stress, disrupted synaptic plasticity, altered metabolism and an imbalance between excitatory and inhibitory signaling.
The finding could help explain something particularly characteristic of depression: the tendency for negative memories and experiences to dominate. New hippocampal neurons are thought to contribute to pattern separation β our ability to distinguish a new experience from similar memories in the past.
There is an important caveat: this study shows an association in post-mortem human brains. It does not prove that reduced neurogenesis causes depression, nor does it mean simply increasing neuron production would cure it.
But it moves one long-standing theory of depression from animal experiments much closer to human biology.
Depression may not simply change how neurons communicate.
It may change how the brain renews itself.
#Neuroscience #Depression #Brain #Neurogenesis #MentalHealth #Science
https://www.nature.com/articles/s41591-026-04571-8
Nature
Dysregulated adult hippocampal neurogenesis in major depressive disorder
Nature Medicine - The largest multiomic atlas of the adult human hippocampus identifies disrupted neurogenesis, gene regulation and neural circuits in major depressive disorder, revealing molecular...
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π‘ Scientists Made a Semiconductor That Can Be Reprogrammed With Light
Most computer chips are born with a fixed job. Once a semiconductor is fabricated, its electrical properties are largely locked in.
Researchers at Princeton have now created an ultrathin semiconductor β only a few molecules thick β that can repeatedly change how it conducts electricity in response to different wavelengths of light. The effect is reversible, meaning the material can be programmed, erased and programmed again.
The team achieved this by combining a two-dimensional semiconductor with light-sensitive molecules that physically change shape when illuminated. Those molecular changes alter the semiconductorβs electronic and optical behavior. And unlike a simple binary switch, the response can be adjusted gradually rather than just flipped between β0β and β1.β
The researchers have already produced uniform samples about one inch across and built arrays of programmable electronic switches. Their next goal is to connect them into functioning circuits.
The broader idea is striking: instead of manufacturing a chip for one fixed purpose, future electronics might be able to change their own physical behavior after they are built.
Software is already reprogrammable.
Now the hardware itself is starting to learn the trick.
#Semiconductors #Computing #MaterialsScience #Photonics #Technology #Science
https://www.science.org/doi/10.1126/sciadv.aee1510
Most computer chips are born with a fixed job. Once a semiconductor is fabricated, its electrical properties are largely locked in.
Researchers at Princeton have now created an ultrathin semiconductor β only a few molecules thick β that can repeatedly change how it conducts electricity in response to different wavelengths of light. The effect is reversible, meaning the material can be programmed, erased and programmed again.
The team achieved this by combining a two-dimensional semiconductor with light-sensitive molecules that physically change shape when illuminated. Those molecular changes alter the semiconductorβs electronic and optical behavior. And unlike a simple binary switch, the response can be adjusted gradually rather than just flipped between β0β and β1.β
The researchers have already produced uniform samples about one inch across and built arrays of programmable electronic switches. Their next goal is to connect them into functioning circuits.
The broader idea is striking: instead of manufacturing a chip for one fixed purpose, future electronics might be able to change their own physical behavior after they are built.
Software is already reprogrammable.
Now the hardware itself is starting to learn the trick.
#Semiconductors #Computing #MaterialsScience #Photonics #Technology #Science
https://www.science.org/doi/10.1126/sciadv.aee1510
Science Advances
Large-area, photo-programmable 2D semiconductors with chromic molecular functionalization
Large-area films of atomically thin hybrid heterostructures enable light-programmable electronics.
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