DD for HSP:

1)Idiopathic Thrombocytopenic Purpura (ITP):
-Isolated thrombocytopenia in healthy child with no joint involvement. BM may show increase in megakaryocytes.

2)Meningococcemia:
The child is very ill, toxic with high fever. DIC may occur.

3)Leukemia:
CBC is important with BM.

4)Acute hemorrhagic edema (AHE):
-Which is an isolated cutaneous leukocytoclastic vasculitis that affects infants <2 yr of age, resembles HSP clinically.
-The younger age, the nature of the lesions, absence of other organ involvement, and a biopsy may help distinguish AHE from HSP.

According to clinical presention, may be DD of arthritis and so on.

#Pediatrics

In HSP:

-Normal platelets count.
-50% of patients have increased serum IgA.
-Antinuclear antibody (ANA), rheumatoid factor (RF), and antineutrophil cytoplasmic antibodies (ANCA) are negative.
-Common but nonspecific findings include leukocytosis, thrombocytosis, mild anemia, and elevations (ESR) and CRP.

#Pediatrics

Diagnosis of HSP.

#Pediatrics

Causes of Hemiplegia, investigations, and stroke in that age.

#Pediatrics

Important.

#Pediatrics

DD of acute Paralysis in children.

#Pediatrics

GBS D.D.

Remember:
GBS is the most common cause of acute paralysis in children.

#Pediatrics

In new Update:

-The most common cause of death in GBS is cardiac arrhythmias.

#Neurology

Remember:

-Triad of acute symmetrical ascending paralysis of limbs, areflexia and albumino: cytological dissociation in CSF is highly suggestive of GBS.

#Neurology

What are the dangerous complications of GBS (cause of death)?

-Respiratory muscle paralysis. The patient may develop respiratory failure within hours type 2.
-Bulbar palsy (dysphagia, nasal regurgitation)
-Cardiac conduction block
-Cardiac arrythmia.

#Neurology

-All patients with GBS should be given subcutaneous fractionated or unfractionated heparin and support stockings until they are able to walk independently to prevent deep vein thrombosis.

#Neurology

-Botulinum toxin is so potent that you need only a taste of contaminated food to kill you .. as little as 0.05 micrograms would kill you.

-But How it does that ?
Well , it does so by irreversibly binding and sticking to your cholinergic nerve terminals , no Acetylcholine would be released , you will be paralysed from Up downwards " descending paralysis " eventually reaching the muscles responsible for your respiration leading to death from respiratory failure all that and the toxin only acts peripherally as it Doesn't cross the Blood Brain Barrier.

#Infections

Remember:

Campylobacter jejuni: campylobacter enteritis is the most common disease associated with GBS.

Cytomegalovirus: most common virus associated with GBS.

#Neurology

In GBS

-Albuminocytologic dissociation, characterized by elevated protein levels and normal cell counts in cerebrospinal fluid (CSF), is a hallmark finding of GBS.

#Neurology

Remember:

It's simple, just believe in your abilities.