💊 AI-Discovered Drug Reverses Aging Markers in Study

Insilico Medicine, a clinical-stage company focused on generative AI-driven drug discovery and development, announced the publication of a new study conducted in collaboration with an international team of scientists from Harvard Medical School, Stanford University, The Broad Institute, RWTH Aachen University, Peking University and Westlake University.

📝 Using longitudinal Olink proteomic data (CNCB OMIX accession: OMIX008341) collected during a Phase IIa clinical trial of rentosertib, researchers evaluated biological age using 6 internationally recognized, independently developed proteomic aging clocks.

🔜 All 6 models consistently indicated a reduction in predicted biological age among patients treated with rentosertib. In addition, the Forced Vital Capacity (FVC), the essential measure of lung function declining with age, showed promising dose-dependent reversal compared to placebo aligning with the proteomic aging clock age reversal.

❗️Recently published in Nature Biotechnology, the study represents the first clinical evaluation of a potentially first-in-class drug candidate featuring both an AI-discovered target with relevance to aging and disease biology and an AI-designed molecule, rather than a repurposed generic drug such as rapamycin or metformin.

The findings also provide a proof-of-concept framework for integrating aging biomarkers into standard clinical trials to accelerate the discovery of geroprotective drugs and longevity therapeutics. 🚀

The results will be presented by first author Alex Zhavoronkov, founder and CEO of Insilico Medicine, at the Nature conference: Redefining Healthcare in the Age of AI, to be held at Sorbonne University in Paris on September 8, 2026.

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🌍 Starlink works in the middle of the Arctic Ocean

24 hours of travel, four flights and one snowmobile to reach Ice Camp, 200 miles north of Alaska. And they still get online to stream on Starlink.

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Sep 4: Coindesk on 📱

NEW: StellarOrg's RWA market is up 360% this year, reaching $4B, and is now #1 across all blockchains in tokenized non-U.S. government debt.

Denelle Dixon says, "real-world assets do not just belong to the United States."

🇸🇮 Slovenia approved Tesla's FSD (Supervised)

The rollout will begin soon. It is another step in Tesla's push to bring FSD across Europe, alongside recent moves in Sweden and France. Now FSD available in 6 European countries: Netherlands, Lithuania, Estonia, Denmark, Belgium, Slovenia.

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🤖 AI may soon allow humans to talk with animals — but some say it could violate their right to privacy

Advancements in AI may soon allow humans to talk with animals, but some groups claim the research could be violating the animals’ right to privacy. Machine learning models are paving the way to catalogue and even mimic the sounds animals make to communicate with each other, with researchers touting the technology as a way to better understand the world of animals.

But “one risk that is currently not taken into account in research ethics is the concern that we might be violating the privacy of animals by collecting data on their vocalizations and movements,” according to researchers in an article published in Springer Nature.

“An interest in privacy is an interest in controlling how you appear to others, and the complex social lives of many nonhuman animals offer strong support for thinking animals have this interest.”

The ability to “speak” with animals also could pose dangers to the natural world, experts said. The controversy involves a technique known as “playback,” which is the practice of broadcasting recorded animal calls in the wild.

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⚡️🇮🇳 India Eyes AI for Next Finance Leap After Digital Payments Boom

India spent the past decade transforming how money moves, with its home-grown real-time payments system changing the way millions of people pay. Now, it is preparing for a bigger leap as AI reshapes finance.

AI could take India’s financial system beyond simply processing transactions, helping assess borrowers, detect fraud, tailor financial products and eventually make payments on behalf of consumers. But giving machines such a big role increases risks of bias, fraud, cybersecurity, data privacy and accountability.

Those questions will take center stage at the annual Global Fintech Fest in Mumbai, where policymakers, bankers, technology companies and fintech founders will gather to debate what comes after the Unified Payments Interface, which unleashed a digital-payments revolution.

The conference, running from Sept. 8-11, will evaluate the potential impact of agentic AI, alongside tokenization and quantum technology. 🚀

#BRICS

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🧑‍⚖️🇪🇺 Macron Demands EU Action to Ban Social Media for Kids Under 15

French President Emmanuel Macron urged Ursula von der Leyen to back European Union-level legislation to ban social media for children under 15 after his own efforts failed in France.

In a letter dated 29 August to von der Leyen he stated it was “now essential to go further and harmonise this provision through a new European text.”

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⚡️💰 Visa is expanding data offering for blockchain lenders as demand for stablecoin-linked cards surges

Visa will pair its settlement data with onchain lending infrastructure, giving lenders greater insight into the financial performance of digital asset-focused fintech firms and card issuers. The program aims to speed up borrowing for these businesses as they grow rapidly.

❗️Visa currently operates more than 160 stablecoin-linked card programs for issuers and program managers, a nearly 200% increase year over year as more crypto businesses launch cards for customers.

“Stablecoin-linked cards are in hypergrowth mode,” — Cuy Sheffield, head of crypto at Visa.

🔜 He said there are new issuers, including stablecoin neobanks and fintech firms, joining the network and launching cards every week.

🔜 To meet the demand surge and need for capital, the company is establishing partnerships to allow new issuers access to financing programs through smart contracts and onchain credit.

“We’ve been running a pilot with a company called Credit Coop that is enabling a credit facility for stablecoin-linked card providers, which we think is a positive step forward for how onchain credit can start to come into our network,” — Sheffield said.

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🤖 XPENG Launches World's First Automated Humanoid Robot Production Line

Chinese EV maker XPENG unveiled the world's first fully automated production line for advanced humanoid robots at its Guangzhou facility, with over 80% of core processes handled by machines drawing from its automotive know-how.

"This was uncharted territory, and we solved it from scratch. The commissioning of our production line means humanoid robots are now ready to scale up and step into the real world," — XPENG said.

Mass production starts by end of 2026 for internal use, with customer deliveries in China and abroad planned for 2027, amid similar scaling by Tesla's Optimus program.

#BRICS

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🔥 Circle Expands Global Payments Infrastructure with Agreement to Acquire Singapore-based Cross-Border Payments Platform, Tazapay

Circle has signed a definitive agreement to acquire Tazapay, a Singapore-headquartered B2B cross-border payments infrastructure company focused on serving payment service providers and financial institutions.

❗️The deal is expected to close in 2027, subject to customary closing conditions and receipt of regulatory approvals, including approval from the Monetary Authority of Singapore.

"Stablecoin settlement is becoming core infrastructure in the global economy and combining USDC with Tazapay’s world-class banking relationships, local payout rails, and institutional customer base will accelerate worldwide USDC adoption,” — said Jeremy Allaire, Co-Founder, CEO, and Chairman at Circle.

The acquisition will accelerate Circle's mission to build the infrastructure layer for global digital finance. Tazapay brings over $25 billion of annualized payment volume, 60+ banking and fintech partners, local payout rails covering over 100 markets, adding scale to Circle’s payments infrastructure.

Approximately 60% of Tazapay's transaction volume already includes stablecoins. 🚀

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⚡️🧬 AlphaGenome Atlas: A predictive map of every possible DNA letter change in the human genome

Google DeepMind is introducing AlphaGenome Atlas: a platform containing predictions for the effects of 9 billion single-nucleotide variants — every single-letter change possible — in the human genome. It is the most comprehensive catalogue of how genetic mutations affect molecular biology, and it is available for academic research through an intuitive and free-to-use website portal.

DNA is the language of life. Mastering it is a grand challenge that could transform our ability to understand biology and treat disease. But progress has been limited by a fundamental problem: interpreting how genetic variations impact biology at a molecular level. With roughly 9 billion possible single-letter mutations in the human genome, testing each one in the lab is practically impossible.

Google DeepMind has already made progress on this challenge with AlphaGenome, an AI model that can predict how genetic variants impact biological processes. AlphaGenome is helpful for analyzing specific variants and has found widespread use in research.

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🤑 Pyth Pro and Pyth Indices Bring 24/7 Pricing to Stellar’s $4B RWA Ecosystem

Stellar now hosts more than $4 billion in tokenized RWAs. Those assets move on infrastructure that stays online around the clock. The markets they represent often do not.

❗️That creates a specific pricing problem. A tokenized asset can remain transferable onchain while the underlying cash market is closed. Applications still need a price to value collateral, manage risk, account for vaults, and support trading.

⚡️Pyth Pro and Pyth Indices are now live on Stellar:

🔘Pyth Indices extend pricing beyond the sessions of the underlying market, while Pyth Pro gives builders access to low-latency market data across asset classes.

🔘Pyth Indices are constructed products that provide 24/7 pricing for assets whose underlying markets follow exchange hours. The catalog includes indices for Brent, natural gas, copper, and oil, alongside single-name equity indices for AAPL, NVDA, TSLA, MSTR, GOOGL, MSFT, MU, and SPCX.

On Stellar, a perpetuals market or vault can continue marking equity-linked and commodity exposure through weekends and holidays, when the cash market is closed. Collateral values, risk controls, and portfolio accounting can continue updating instead of waiting for the next session open. 🚀

#Stellar

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🧑‍⚖️🇷🇺 Russian Courts Begin Testing Four AI Models Trained on Judicial Practice

Russia has begun to create a new automated Digital Justice system, which involves the introduction of AI technologies at all stages of legal proceedings. This was announced on September 5 by Chairman of the Supreme Court of the Russian Federation Igor Krasnov at the Forum of Chairmen of the Supreme Courts of the BRICS countries.

The goal of the project is to combine all existing judicial services and ensure their seamless integration with a single portal of public services. The system will be based on Russian technical and software solutions.

"We are talking about transcribing court records, analyzing evidence, and forming document templates," — Krasnov said.

#BRICS

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🤖 PsiQuantum Finalizes $100 Million Award with the U.S. Department of Commerce

PsiQuantum has signed definitive documentation with the U.S. Department of Commerce for a $100 million award to strengthen American leadership in quantum computing and semiconductor supply-chain security. 🏆

With federal funding made possible through the CHIPS and Science Act, combined with co-investment by the company in the project, PsiQuantum will accelerate the R&D, domestic manufacturability, and performance of its state-of-the-art critical components, including high-performance optical switches, high-temperature single-photon detectors, and advanced packaging approaches.

“PsiQuantum is proud to anchor our supply chains here in the U.S. Thanks to the leadership of the U.S. government, our company will be able to manufacture even more of our state-of-the-art components in America,” — said Victor Peng, Chief Executive Officer of PsiQuantum.

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⚡️🇺🇸🇨🇦 Trump Plans to Cut Canadian Products Out of Government Contracts

President Donald Trump said he would direct the General Services Administration and USTR to remove Canadian-origin products from federal government contracts, hitting back at Ottawa over retaliatory tariffs and escalating the trade war between the two neighbors.

The moves will take place “unless Canada restores full and fair reciprocity for American Farmers and Companies,” Trump announced. Trump said the so-called Multiple Award Schedules are worth more than $50 billion each year.

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🤑 Stellar doesn't take Sundays off

Stellar processed over 11.6M transactions yesterday, reaching its highest daily throughput in the past week. Global payments run every day, and Stellar is built to keep up. 🚀

No days off. No hours off. No minutes off. No seconds off.

#Stellar

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🤖 OpenAI Says It Has Solved a Millennium Prize Problem — a Holy Grail of Math

OpenAI said that one of its internal models has solved the Navier-Stokes existence and smoothness problem, a fundamental question about the rules that describe how liquids and gases move.

For nearly a century, mathematicians have tried to determine whether smooth solutions to the equations describing three-dimensional fluid motion always remain smooth or if they ever break down.

To put it less mathematically: On paper, can water blow up? 🤔

📝 OpenAI says its model found a scenario in which “an initially smooth fluid at rest can develop a singularity in a finite time.” In the proof, a spaghetti-like vortex gets smaller while spinning faster and faster, its speed growing without limit in what mathematicians call “finite-time blowup.”

OpenAI published its findings along with the 165-page proof and a formalization that verifies the argument step by step. The company says it took as many as 10,000 AI agents working together on the problem about 88 hours to find the solution.

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🛡 Ethereum makes quantum resistance a top priority with a 2029 deadline

The Ethereum Foundation has given itself until December 2029 to make Ethereum resistant to quantum computers across the parts of the network that process transactions, secure validators and store data.

🔘The Foundation’s Protocol cluster is planning for that 2030 threat horizon, but has locked in a 2029 completion target. That deadline stands at least until January 2027, when outside experts will reassess how fast quantum computing is actually moving.

🔘The upcoming Hegotá upgrade will not provide quantum resistance itself but is intended to keep five subsequent hard forks and related cryptographic changes on schedule.

Planned protections include new account and validator signature systems, a public-key registry and a fallback designed to keep Ethereum operating with reduced guarantees if quantum computers advance sooner than expected.

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🤘 Meta Debuts Muse AI Assistant for Personal Tasks and Organization

Meta Platforms Inc. unveiled a new AI agent designed to carry out tasks on a user’s behalf, advancing Mark Zuckerberg’s vision of a future where people each have a personalized AI assistant.

Called Muse, the new agent shares its name with the series of models Meta’s AI lab is developing and can help automate a variety of tasks. Meta said the tool will assist with online shopping, buying movie tickets, scheduling appointments like tennis lessons or even filling out a permission slip for a class field trip.

The app will be released to US-based users on Tuesday. 🚀

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