a rare autosomal dominant syndrome associated with multiple gastrointestinal hamartomatous polyps and mucocutaneous hyperpigmentation:

most occur in children younger than 5 years and involve the rectum:

They have no malignant potential, usually smaller than 5 mm:

associated with mucocutaneous hyperpigmentation:

They are characterized by the presence of epithelial dysplasia

It is a malignant tumor:

intermittent attacks

cobblestone appearance

pancolitis

fissure and fistula tract are common

it may occur as complication of GERD

there extra-intestinal manifestations, as cholangitis

usually smaller than 10mm

transmural inflammation with lymphoid aggregates

Depending on the segment affected , extensive lesion can lead to malabsorption and malnutrition , loss of albumin ( proteinlosing enteropathy ) , iron - deficiency anemia , and / or B12 deficiency

it can be pedunculated or sessile

Precursors to the majority of colorectal carcinoma