إزاي بيتم معرفة الـmechanism of action لدواء معين؟

🎯 Target Identification:
The process begins by identifying the drug's molecular target(s) within the body.

🔬 In vitro Studies:
Controlled laboratory experiments are conducted to assess the drug's interactions with its molecular targets.

🧫 Cell Culture Studies:
Assays are performed to evaluate the drug's effects on cellular processes and signaling pathways.

🐭 Animal Studies:
Preclinical trials in animals help understand the pharmacological effects and mechanisms of action of the drug in living organisms.

💉 Clinical Trials:
Human trials provide insights into the drug's safety, efficacy, and mechanism of action in real-world settings.

🧬 Molecular Biology and Imaging Techniques:
Techniques like gene expression analysis and imaging help study drug-target interactions and physiological changes.

💻 Computational Modeling and Bioinformatics:
Computational methods predict drug-target interactions and analyze binding affinities.

📊 Integration of Data:
Data from various studies are integrated to develop a comprehensive understanding of the drug's mechanism of action.

#PDFology
#غزه_تباد 🇵🇸

قال أبي سعيد الخدري رضي الله عنه: قال رسول الله صلى الله عليه وسلم: من قرأ سورة الكهف في يوم الجمعة، أضاء له من النور ما بين الجمعتين. رواه الحاكم والبيهقي وصححه الألباني.

﴿ إِنَّ اللَّهَ وَمَلَائِكَتَهُ يُصَلُّونَ عَلَى النَّبِيِّ ۚ يَا أَيُّهَا الَّذِينَ آمَنُوا صَلُّوا عَلَيْهِ وَسَلِّمُوا تَسْلِيمًا﴾
[ الأحزاب: 56]

#quiz
#غزه_تنتصر 🇵🇸

Antibiotics names made easy 💊

#ابو_عبيده 🇵🇸

#Ramadan 🌙

Medications antidote 💊

#ابو_عبيده 🇵🇸

#quiz
#غزه_تنتصر 🇵🇸

إيه الفرق بين
Rheumatoid Arthritis (RA)
🆚 Psoriatic Arthritis (PsA)?

📋 The key differences between Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA):

Joint Involvement:

* RA: Multiple joints, often symmetrical (both sides affected equally).
Think of a mirror image where both sides have matching joint pain. 🪞
* PsA: Fewer joints, often asymmetrical (one side affected more than the other). Imagine pain like a party happening on just one side of your joints .

Symptoms:

* RA: Pain, stiffness, swelling, and warmth in the joints, often worse in the mornings. ☀️
* PsA: Pain, stiffness, swelling, and sometimes sausage-like swelling in fingers and toes. ️

Cause:

* RA: Autoimmune disease - the body's immune system attacks healthy tissues in the joints. ‍⚔️
* PsA: Exact cause unknown, but linked to genetics and psoriasis (a skin condition).

Diagnosis:

* RA: Blood tests (rheumatoid factor & CCP antibodies) and X-rays. Blood tests check for specific markers, and X-rays show joint damage. 🩻
* PsA: No single test, diagnosis based on symptoms, X-rays, and sometimes MRI scans. 🩻

Treatment:

* RA: Medications to slow disease progression and manage symptoms (like pain relievers & DMARDs). 💊
* PsA: Similar to RA, with additional options for skin symptoms if present.

Reference ➡️ Pubmed 🌐

#Vs
#غزه_تنتصر 🇵🇸

#quiz
#غزه 🇵🇸

قال أبي سعيد الخدري رضي الله عنه: قال رسول الله صلى الله عليه وسلم: من قرأ سورة الكهف في يوم الجمعة، أضاء له من النور ما بين الجمعتين. رواه الحاكم والبيهقي وصححه الألباني.

﴿ إِنَّ اللَّهَ وَمَلَائِكَتَهُ يُصَلُّونَ عَلَى النَّبِيِّ ۚ يَا أَيُّهَا الَّذِينَ آمَنُوا صَلُّوا عَلَيْهِ وَسَلِّمُوا تَسْلِيمًا﴾
[ الأحزاب: 56]

Diabetes mellitus by PDFology

#Endocrine

#PDFology
#غزه 🇵🇸

#quiz
#غزه 🇵🇸

Short practice summary boxes

By Dr Sabir Abdulrahman

#Surgery
#مستشفي_الشفاء 🇵🇸