In Silico SARS-CoV-2 Epitopes Inhibit-possibilities

"Identification of potential edible mushroom as SARS‑CoV‑2 main protease inhibitor using rational drug designing approach

[.] we have identified promising hits against the main protease (Mpro) of SARS-CoV-2 from edible mushrooms. Structure-based virtual screening (VS) of 2433 compounds derived from mushrooms was performed with Mpro protein (6LU7). Four promising hits, [.], Kynapcin-12 (M_78), Kynapcin-28 (M_82), Kynapcin-24 (M_83), and Neonambiterphenyls-A (M_366) were identifed [.]

The promising hits Kynapcin-12 (M_78), Kynapcin-28 (M_82), Kynapcin-24 (M_83) are available in edible #mushroom Polyozellus multiplex and another promising hit Neonambiterphenyls-A (M_366) is available in the poisonous mushroom Neonothopanus nimbi.

[.] scores greater than co-ligand and comparable docking scores with the two known SARS-CoV-2 inhibitors."

Received: 30.7.2021
Accepted: 03.1.2022

Nature
1, 2, 3
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Yes, Kynapcin could be in Cubensis.

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Tens of Thousands Roll Into Ottawa for Protest Against Canada’s COVID-19 Vaccine Mandates

🇨🇦@COVID19Up: Tens of thousands of people rolled into Canada's capital Ottawa on Saturday (Jan. 29) for a massive protest against Prime Minister Justin Trudeau's COVID-19 vaccine mandates in front of parliament on a frigid winter day.

The "Freedom Convoy"—coming from east and west—started out as a rally against a COVID-19 vaccine requirement for cross-border truckers, but has turned into a demonstration against government overreach during the pandemic.

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