Regional nodal metastasis are uncommon, it tends to metastasize through thr bloodstream

Solitary cold thyroid nodule

Is increased in areas of dietary iodine deficiency

30% are familiar or associated with MEN syndromes

One of the most aggressive human neoplasms

Death occurs in less than 1 year before it metastasize because of compromise of vital structures in the neck

Acellular amyloid deposits are presented

Neuroendocrine neoplasms

Patients with it have the older age (a mean of 65 yaers)

Large lesions contain areas of necrosis and hemorrhage