Two doses of The Oxford Covid-19 Vaccine Shots 89% Effective: UK Real-World Analysis
▫️Two doses of The Oxford & AstraZeneca Covid-19 Vaccine Are Around 85% To 90% Effective Against Symptomatic Disease, Public Health England (PHE) Said on Thursday, Citing An Analysis of Real-World Data from The Rollout of The Shot.
▫️In A Weekly Surveillance Report, Public Health England Said The Estimated Effectiveness of The AstraZeneca Vaccine, Invented At The University of Oxford, Was 89% Compared To Unvaccinated People.
▫️That Compares To 90% Estimated Effectiveness Against Symptomatic disease for The Pfizer-BioNTech Vaccine.
▫️PHE Said The Analysis Was The First of Its Kind on The Effectiveness of Two doses of AstraZeneca In A Real-World Setting But Was Not Yet Published in A Journal, Adding More Data Would Boost Its Confidence In The Finding.
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▫️Two doses of The Oxford & AstraZeneca Covid-19 Vaccine Are Around 85% To 90% Effective Against Symptomatic Disease, Public Health England (PHE) Said on Thursday, Citing An Analysis of Real-World Data from The Rollout of The Shot.
▫️In A Weekly Surveillance Report, Public Health England Said The Estimated Effectiveness of The AstraZeneca Vaccine, Invented At The University of Oxford, Was 89% Compared To Unvaccinated People.
▫️That Compares To 90% Estimated Effectiveness Against Symptomatic disease for The Pfizer-BioNTech Vaccine.
▫️PHE Said The Analysis Was The First of Its Kind on The Effectiveness of Two doses of AstraZeneca In A Real-World Setting But Was Not Yet Published in A Journal, Adding More Data Would Boost Its Confidence In The Finding.
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South Korea Approves Moderna's Covid-19 Vaccine
▫️South Korea on Friday Approved Moderna Covid-19 Vaccine, As The Country Attempts To Speed Up Its Inoculation Efforts.
▫️The Green Light Comes After Two of Three Expert Panels Recommended Approval Be Granted for The Two-dose Vaccine Based on Safety And Efficacy in Late-Stage Trials in The United States.
▫️Moderna is The fourth Covid-19 Vaccine To Be Approved in South Korea, following doses Developed by Oxford-AstraZeneca, Pfizer, And Johnson & Johnson.
▫️Moderna Has A Deal With South Korea To Supply 40 Million doses of Its Vaccine, Although The Shipment Timeline Is Yet To be Announced.
▫️Seoul Has Ordered Up To 192 Million doses of Coronavirus Vaccines, Including Those Made by AstraZeneca, Pfizer, Novavax And Johnson & Johnson.
@MedicalNoteBook
▫️South Korea on Friday Approved Moderna Covid-19 Vaccine, As The Country Attempts To Speed Up Its Inoculation Efforts.
▫️The Green Light Comes After Two of Three Expert Panels Recommended Approval Be Granted for The Two-dose Vaccine Based on Safety And Efficacy in Late-Stage Trials in The United States.
▫️Moderna is The fourth Covid-19 Vaccine To Be Approved in South Korea, following doses Developed by Oxford-AstraZeneca, Pfizer, And Johnson & Johnson.
▫️Moderna Has A Deal With South Korea To Supply 40 Million doses of Its Vaccine, Although The Shipment Timeline Is Yet To be Announced.
▫️Seoul Has Ordered Up To 192 Million doses of Coronavirus Vaccines, Including Those Made by AstraZeneca, Pfizer, Novavax And Johnson & Johnson.
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The European Medicines Agency Permits Use of GSK-Vir Antibody To Treat Covid-19
▫️The European Medicines Agency (EMA) Said on Friday a Covid-19 Antibody Treatment Developed by GlaxoSmithKline (GSK) And Vir Biotechnology Can Be Used To Treat Patients Who Are At Risk of Severe Disease And Do Not Need Supplemental Oxygen.
▫️The Opinion Relates To The Use of The Treatment, Sotrovimab, In Adults And Adolescents Aged 12 Years Or Older And Weighing At Least 40 Kilograms.
▫️“Based on Our Most Recent In Vitro Data, Sotrovimab Continues To Combat Covid-19 As It Evolves And Has Retained Activity Against All Circulating Variants of Concern,” Vir Chief Executive George Scangos Said In A Joint Statement With GSK.
▫️Interim Data from A Study of The Experimental Therapy Showed 85% Reduction in Hospitalization And Deaths Among Covid-19 Patients, GSK And Vir Had Said.
▫️The Rolling Review of The Drug Is Ongoing, The European Medicines Agency (EMA) Said.
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▫️The European Medicines Agency (EMA) Said on Friday a Covid-19 Antibody Treatment Developed by GlaxoSmithKline (GSK) And Vir Biotechnology Can Be Used To Treat Patients Who Are At Risk of Severe Disease And Do Not Need Supplemental Oxygen.
▫️The Opinion Relates To The Use of The Treatment, Sotrovimab, In Adults And Adolescents Aged 12 Years Or Older And Weighing At Least 40 Kilograms.
▫️“Based on Our Most Recent In Vitro Data, Sotrovimab Continues To Combat Covid-19 As It Evolves And Has Retained Activity Against All Circulating Variants of Concern,” Vir Chief Executive George Scangos Said In A Joint Statement With GSK.
▫️Interim Data from A Study of The Experimental Therapy Showed 85% Reduction in Hospitalization And Deaths Among Covid-19 Patients, GSK And Vir Had Said.
▫️The Rolling Review of The Drug Is Ongoing, The European Medicines Agency (EMA) Said.
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The European Medicines Agency Backs Extending Approval for Remdesivir For Another Year
▫️The European Medicines Agency (EMA) on Friday Recommended Extending Conditional Marketing Approval By A Year for Gilead Sciences’ Covid-19 Treatment, Remdesivir, The Only Drug So far That Has Been Authorized for Use In The Region.
▫️The Regulator Said Its Human Medicines Committee (CHMP) found That Benefits of The Drug Outweighed Risks, Although The Company Was Required To Submit More Data by The End of The Year for The Next Scheduled Renewal.
▫️Remdesivir, Sold Under The Brand Name Veklury, Was Conditionally Authorized In July Last Year for Treating Covid-19 In Adults And Adolescents Over 12 Years With Pneumonia Requiring Oxygen Support.
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▫️The European Medicines Agency (EMA) on Friday Recommended Extending Conditional Marketing Approval By A Year for Gilead Sciences’ Covid-19 Treatment, Remdesivir, The Only Drug So far That Has Been Authorized for Use In The Region.
▫️The Regulator Said Its Human Medicines Committee (CHMP) found That Benefits of The Drug Outweighed Risks, Although The Company Was Required To Submit More Data by The End of The Year for The Next Scheduled Renewal.
▫️Remdesivir, Sold Under The Brand Name Veklury, Was Conditionally Authorized In July Last Year for Treating Covid-19 In Adults And Adolescents Over 12 Years With Pneumonia Requiring Oxygen Support.
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People With Newly Diagnosed AD Are Less Likely To Have Cataract Surgery Than People Without AD
▫️People With Alzheimer's Disease (AD) Are Less Likely To Have Cataract Surgery Than People Without Alzheime's Disease. The Procedure Rate Starts To Decrease Already One Year After The Diagnosis, According To A New Study from The University of Eastern Finland.
▫️The Lower Likelihood of Cataract Surgery Among People With Cognitive Disorders Has Been Reported Previously.
▫️People With Alzheimer's Disease (AD) Are Less Likely To Have Cataract Surgery Than People Without Alzheime's Disease. The Procedure Rate Starts To Decrease Already One Year After The Diagnosis, According To A New Study from The University of Eastern Finland.
▫️The Lower Likelihood of Cataract Surgery Among People With Cognitive Disorders Has Been Reported Previously.
Wiley Online Library
Incidence of cataract surgeries in people with and without Alzheimer’s disease
Purpose
To investigate the incidence of cataract surgeries in relation to Alzheimer’s disease (AD) diagnosis and to compare it with that in people without AD.
Methods
The MEDALZ–study includes com...
To investigate the incidence of cataract surgeries in relation to Alzheimer’s disease (AD) diagnosis and to compare it with that in people without AD.
Methods
The MEDALZ–study includes com...
Scientists Identify Receptor in Cells That Could Be Key To Preventing Cancer Drug-Induced Hearing Loss
▫️University of Alberta Scientists Have Identified A Receptor in Cells That Could Be Key To Preventing Permanent Hearing Loss In Childhood Cancer Survivors Who Are Being Treated with The Drug Cisplatin.
▫️The Researchers Believe by Inhibiting The Receptor, They May be Able To Eliminate Toxic Side-Effects from The Drug That Cause The Hearing Loss.
http://dx.doi.org/10.15252/embr.202051280
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▫️University of Alberta Scientists Have Identified A Receptor in Cells That Could Be Key To Preventing Permanent Hearing Loss In Childhood Cancer Survivors Who Are Being Treated with The Drug Cisplatin.
▫️The Researchers Believe by Inhibiting The Receptor, They May be Able To Eliminate Toxic Side-Effects from The Drug That Cause The Hearing Loss.
http://dx.doi.org/10.15252/embr.202051280
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www.embopress.org
Toll‐like receptor 4 is activated by platinum and contributes to cisplatin‐induced ototoxicity | EMBO reports
Cisplatin is invaluable in cancer treatment, but its use is limited due to cisplatin-induced ototoxicity. TLR4 is activated by cisplatin, contributing to cisplatin-induced hair cell death, but geneti...
Biogen’s Eye Disease Gene Therapy Fails Ahead of FDA Alzheimer’s Ruling
▫️Biogen Has Downbeat News About Its Gene Therapy for The Rare Inherited Eye Disease, X-Linked Retinitis Pigmentosa, Announcing The Shot Failed To Meet Its Target In A Phase 2/3 Study.
▫️A Final FDA Decision on Biogen’s Controversial Alzheimer’s Drug Aducanumab Is Due Before The Beginning of Next Month And The Company Needs Some Positive Pipeline News Ahead of The Make-Or-Break Ruling.
▫️In Ophthalmology, Unfortunately The Phase 2/3 Study of Cotoretigene Toliparvovec (BIIB112), A Gene Therapy Being Investigated As A One-Time Therapy for Patients With X-Linked Retinitis Pigmentosa (XLRP), Did Not Meet Its Primary Endpoint of Demonstrating A Statistically Significant Improvement In The Proportion of Treated Study Eyes Improving from Baseline Using A Macular Integrity Assessment.
▫️This Assessment Was Performed at 12 Months And Compared To The Study Eye of Patients Randomized To The Untreated Control Group.
▫️Biogen Said That Positive Trends Were Observed Across Several Clinically Relevant Pre-Specified Secondary Endpoints.
▫️A Phase 3 Trial Is Ongoing And Although There Was No Update On Efficacy Or Safety, The Company Said It Plans To Provide Early Access for A Group of Patients With Severe, Rapidly Developing Disease.
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▫️Biogen Has Downbeat News About Its Gene Therapy for The Rare Inherited Eye Disease, X-Linked Retinitis Pigmentosa, Announcing The Shot Failed To Meet Its Target In A Phase 2/3 Study.
▫️A Final FDA Decision on Biogen’s Controversial Alzheimer’s Drug Aducanumab Is Due Before The Beginning of Next Month And The Company Needs Some Positive Pipeline News Ahead of The Make-Or-Break Ruling.
▫️In Ophthalmology, Unfortunately The Phase 2/3 Study of Cotoretigene Toliparvovec (BIIB112), A Gene Therapy Being Investigated As A One-Time Therapy for Patients With X-Linked Retinitis Pigmentosa (XLRP), Did Not Meet Its Primary Endpoint of Demonstrating A Statistically Significant Improvement In The Proportion of Treated Study Eyes Improving from Baseline Using A Macular Integrity Assessment.
▫️This Assessment Was Performed at 12 Months And Compared To The Study Eye of Patients Randomized To The Untreated Control Group.
▫️Biogen Said That Positive Trends Were Observed Across Several Clinically Relevant Pre-Specified Secondary Endpoints.
▫️A Phase 3 Trial Is Ongoing And Although There Was No Update On Efficacy Or Safety, The Company Said It Plans To Provide Early Access for A Group of Patients With Severe, Rapidly Developing Disease.
@MedicalNoteBook
Asthma Vaccine Shows Success In Pre-Clinical Studies
▫️A New Conjugate Vaccine Has Shown Promise At Protecting Mice Against The Effects of Cytokines Associated With Asthma.
▫️Researchers Have Developed A Vaccine That Could Induce Long-Term Protection Against Allergic Asthma, Reducing The Severity of Its Symptoms And Thus Significantly Improving Patient Quality of Life. The Vaccine Was Created At Inserm, Institut Pasteur And NEOVACS, All France.
▫️According To The Team, Allergic Asthma Is Characterized By Inflammation of The Bronchial Tubes And Respiratory Discomfort Caused by The Inhalation of Allergens, Most Often Dust Mites.
- This Exposure To Allergens Leads To The Production of Antibodies Called Immunoglobulin E (IgE) And Type 2 Cytokines (Such As Interleukin-4 (IL-4) And IL-13) In The Airways.
- This Leads To A Cascade of Reactions Resulting In Hyperresponsiveness of The Respiratory Tract, Overproduction of Mucus And Eosinophilia.
▫️The Study Was Published In Nature Communications.
@MedicalNoteBook
▫️A New Conjugate Vaccine Has Shown Promise At Protecting Mice Against The Effects of Cytokines Associated With Asthma.
▫️Researchers Have Developed A Vaccine That Could Induce Long-Term Protection Against Allergic Asthma, Reducing The Severity of Its Symptoms And Thus Significantly Improving Patient Quality of Life. The Vaccine Was Created At Inserm, Institut Pasteur And NEOVACS, All France.
▫️According To The Team, Allergic Asthma Is Characterized By Inflammation of The Bronchial Tubes And Respiratory Discomfort Caused by The Inhalation of Allergens, Most Often Dust Mites.
- This Exposure To Allergens Leads To The Production of Antibodies Called Immunoglobulin E (IgE) And Type 2 Cytokines (Such As Interleukin-4 (IL-4) And IL-13) In The Airways.
- This Leads To A Cascade of Reactions Resulting In Hyperresponsiveness of The Respiratory Tract, Overproduction of Mucus And Eosinophilia.
▫️The Study Was Published In Nature Communications.
@MedicalNoteBook
Nature
Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice
Nature Communications - Asthma is caused by hyperreactivity to benign antigens, with humoral immunity orchestrated by interleukin-4 (IL-4) and IL-13 being the key etiological factor. Here the...
FDA Advises Against Use of SARS-CoV-2 Antibody Test Results to Evaluate Immunity or Protection From COVID-19, Including After Vaccination
▫️The U.S. Food And Drug Administration (FDA) Issued A Safety Communication Informing The Public That Results from SARS-CoV-2 Antibody Tests Should Not Be Used To Evaluate Immunity Or Protection from Covid-19 At Any Time, And Especially After The Person Received A Covid-19 Vaccination.
▫️The FDA Is Reminding The Public of The Limitations of Covid-19 Antibody, Or Serology, Testing And Providing Additional Recommendations About The Use of Antibody Tests In People Who Received A Covid-19 Vaccination.
▫️Antibody Tests Can Play An Important Role In Identifying Individuals Who May Have Been Exposed To The SARS-CoV-2 Virus And May Have Developed An Adaptive Immune Response.
- However, Antibody Tests Should Not Be Used At This Time To Determine Immunity Or Protection Against Covid-19 At Any Time.
@MedicalNoteBook
▫️The U.S. Food And Drug Administration (FDA) Issued A Safety Communication Informing The Public That Results from SARS-CoV-2 Antibody Tests Should Not Be Used To Evaluate Immunity Or Protection from Covid-19 At Any Time, And Especially After The Person Received A Covid-19 Vaccination.
▫️The FDA Is Reminding The Public of The Limitations of Covid-19 Antibody, Or Serology, Testing And Providing Additional Recommendations About The Use of Antibody Tests In People Who Received A Covid-19 Vaccination.
▫️Antibody Tests Can Play An Important Role In Identifying Individuals Who May Have Been Exposed To The SARS-CoV-2 Virus And May Have Developed An Adaptive Immune Response.
- However, Antibody Tests Should Not Be Used At This Time To Determine Immunity Or Protection Against Covid-19 At Any Time.
@MedicalNoteBook
Pfizer And Oxford Covid-19 Shots 'Highly Effective' Against India Variant, Study Shows
▫️The Covid-19 Vaccines Developed By Pfizer-BioNTech And Oxford-AstraZeneca Are "Highly Effective" Against The Indian Variant, A New Study Has Found.
▫️Two Jabs of Either Vaccine Give A Similar Level of Protection Against Symptomatic Disease from The Indian Variant As They do for The B.1.1.7 “Kent" Strain.
- However, Both Vaccines Were Only 33% Effective Against The Indian Variant Three Weeks After The First dose.
▫️The Study Involved 1,054 People Confirmed Through Genomic Sequencing To Have Contracted The B.1.617.2 Variant Between Early April And Mid-May.
▫️A Study by Public Health England found The Pfizer Vaccine Was 88% Effective Against Symptomatic Disease from The B.1.617.2 Variant Two Weeks After The Second dose.
- That Compared With 93% Effectiveness Against The B.1.1.7 “Kent” Strain Which Is Britain’s Dominant Covid-19 Variant.
▫️Two doses of The Oxford Vaccine Were 60% Effective Against Symptomatic Disease from The Indian Variant Compared With 66% Effectiveness Against The Kent Variant, PHE Said.
@MedicalNoteBook
▫️The Covid-19 Vaccines Developed By Pfizer-BioNTech And Oxford-AstraZeneca Are "Highly Effective" Against The Indian Variant, A New Study Has Found.
▫️Two Jabs of Either Vaccine Give A Similar Level of Protection Against Symptomatic Disease from The Indian Variant As They do for The B.1.1.7 “Kent" Strain.
- However, Both Vaccines Were Only 33% Effective Against The Indian Variant Three Weeks After The First dose.
▫️The Study Involved 1,054 People Confirmed Through Genomic Sequencing To Have Contracted The B.1.617.2 Variant Between Early April And Mid-May.
▫️A Study by Public Health England found The Pfizer Vaccine Was 88% Effective Against Symptomatic Disease from The B.1.617.2 Variant Two Weeks After The Second dose.
- That Compared With 93% Effectiveness Against The B.1.1.7 “Kent” Strain Which Is Britain’s Dominant Covid-19 Variant.
▫️Two doses of The Oxford Vaccine Were 60% Effective Against Symptomatic Disease from The Indian Variant Compared With 66% Effectiveness Against The Kent Variant, PHE Said.
@MedicalNoteBook
U.S. CDC Looking Into Heart Inflammation In Some Young Adults Who Received mRNA Covid-19 Vaccines
▫️Some Teenagers And Young Adults Who Received mRNA Covid-19 Vaccines Experienced Heart Inflammation, A U.S. Centers for Disease Control And Prevention (CDC) Advisory Group Said, Recommending Further Study of The Rare condition.
▫️The CDC Said The Cases Typically Occurred Within Four Days After Receiving The mRNA Vaccines. The United States Has Given Emergency Authorization To Two mRNA Vaccines, from Moderna And Pfizer-BioNTech.
▫️The CDC's Advisory Committee on Immunization Practices In A Statement Dated May 17 Said It Had Looked Into Reports That A Few Young Vaccine Recipients, Predominantly Adolescents And Young Adults, And Predominantly Male, Developed Myocarditis, An Inflammation of The Heart Muscle.
▫️Israel's Health Ministry In April Said It Was Examining A Small Number of Cases of Heart Inflammation In People Who Had Received Pfizer's Vaccine.
@MedicalNoteBook
▫️Some Teenagers And Young Adults Who Received mRNA Covid-19 Vaccines Experienced Heart Inflammation, A U.S. Centers for Disease Control And Prevention (CDC) Advisory Group Said, Recommending Further Study of The Rare condition.
▫️The CDC Said The Cases Typically Occurred Within Four Days After Receiving The mRNA Vaccines. The United States Has Given Emergency Authorization To Two mRNA Vaccines, from Moderna And Pfizer-BioNTech.
▫️The CDC's Advisory Committee on Immunization Practices In A Statement Dated May 17 Said It Had Looked Into Reports That A Few Young Vaccine Recipients, Predominantly Adolescents And Young Adults, And Predominantly Male, Developed Myocarditis, An Inflammation of The Heart Muscle.
▫️Israel's Health Ministry In April Said It Was Examining A Small Number of Cases of Heart Inflammation In People Who Had Received Pfizer's Vaccine.
@MedicalNoteBook
Study Indicates That Certain Anti-Cancer Therapies May Hasten Cellular Aging
▫️New Research Indicates That Certain Anti-Cancer Therapies May Hasten Cellular Aging, Where Changes In The DNA of Patients May Contribute To Greater Inflammation And Fatigue.
▫️The Findings Are Published by Wiley Early Online In Cancer, A Peer-Reviewed Journal of The American Cancer Society.
▫️Some Individuals May Experience Epigenetic Age Acceleration (EAA) That Puts Them At A Higher Risk of Age-Related Conditions Than Other Individuals of The Same Chronological Age.
▫️In The Study of 133 Patients With Head And Neck Cancer (HNC), Half of The Patients Experienced Severe Fatigue At Some Point.
▫️EAA Was Most Prominent Immediately After Radiation Therapy, When The Average Epigenetic Age Was Accelerated by 4.9 Years.
@MedicalNoteBook
▫️New Research Indicates That Certain Anti-Cancer Therapies May Hasten Cellular Aging, Where Changes In The DNA of Patients May Contribute To Greater Inflammation And Fatigue.
▫️The Findings Are Published by Wiley Early Online In Cancer, A Peer-Reviewed Journal of The American Cancer Society.
▫️Some Individuals May Experience Epigenetic Age Acceleration (EAA) That Puts Them At A Higher Risk of Age-Related Conditions Than Other Individuals of The Same Chronological Age.
▫️In The Study of 133 Patients With Head And Neck Cancer (HNC), Half of The Patients Experienced Severe Fatigue At Some Point.
▫️EAA Was Most Prominent Immediately After Radiation Therapy, When The Average Epigenetic Age Was Accelerated by 4.9 Years.
@MedicalNoteBook
Wiley
Cancer Treatments May Accelerate Cellular Aging
Epigenetic Changes Associated With Greater Inflammation and Fatigue New research indicates that certain anti-cancer therapies may hasten cellular aging, where changes in the DNA of patients may contribute to greater inflammation and fatigue. The findings…
Little Evidence for mRNA Covid-19 Vaccine-Associated Thrombocytopenia, Suggests New FDA Study
▫️A New Study In The Journal Vaccine Reports The Results of An Evaluation of Reported Cases of This Condition, Using Data from The Vaccine Adverse Event Reporting System (VAERS).
▫️The FDA-Designed VAERS System Envisages The Monitoring of Adverse Events of Special Interest Like Thrombocytopenia That Are Passively Reported. Soon After The Emergency Use Authorization (EUA), Several Reports of Immune Thrombocytopenia (ITP) Came In.
▫️Of The Approximately 19 Million And 16 Million doses of Pfizer And Moderna Vaccine Administered In The USA, Respectively, These Careful Selection Criteria Identified 15 And 13 Cases of Thrombocytopenia, Corresponding To Less Than One Reported Case Per Million doses of Either Vaccine.
- No Sex Difference Was Observed, And The Median Age Was 49 Years, Though The Condition Was Reported From 22 To 82 years.
▫️The Median Duration from Vaccination To Onset of Thrombocytopenia Was 5.5 Days, With A Range of 1-23 Days. Earlier Reports on ITP In Covid-19 Cases Indicated A Median Time of Onset At 13 Days.
- Typically, However, The Presentation Occurred at 2-3 Weeks from Symptom Onset, With Only One In five Patients Presenting Within A Week Or Less.
@MedicalNoteBook
▫️A New Study In The Journal Vaccine Reports The Results of An Evaluation of Reported Cases of This Condition, Using Data from The Vaccine Adverse Event Reporting System (VAERS).
▫️The FDA-Designed VAERS System Envisages The Monitoring of Adverse Events of Special Interest Like Thrombocytopenia That Are Passively Reported. Soon After The Emergency Use Authorization (EUA), Several Reports of Immune Thrombocytopenia (ITP) Came In.
▫️Of The Approximately 19 Million And 16 Million doses of Pfizer And Moderna Vaccine Administered In The USA, Respectively, These Careful Selection Criteria Identified 15 And 13 Cases of Thrombocytopenia, Corresponding To Less Than One Reported Case Per Million doses of Either Vaccine.
- No Sex Difference Was Observed, And The Median Age Was 49 Years, Though The Condition Was Reported From 22 To 82 years.
▫️The Median Duration from Vaccination To Onset of Thrombocytopenia Was 5.5 Days, With A Range of 1-23 Days. Earlier Reports on ITP In Covid-19 Cases Indicated A Median Time of Onset At 13 Days.
- Typically, However, The Presentation Occurred at 2-3 Weeks from Symptom Onset, With Only One In five Patients Presenting Within A Week Or Less.
@MedicalNoteBook
Repurposed Gout Medication "Probenecid' Shows Potent Inhibition of SARS-CoV-2 Replication
▫️New Research by A Team of Scientists In The USA Describes The Potential Utility of A Drug Called Probenecid, Commonly Used To Treat Gout, To Treat This Devastating Viral illness Caused by The SARS-CoV-2 - The Causative Virus of Covid-19.
▫️A Preprint Version of The Study Is Available on The bioRxiv Server, While The Article Undergoes Peer-Review.
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▫️New Research by A Team of Scientists In The USA Describes The Potential Utility of A Drug Called Probenecid, Commonly Used To Treat Gout, To Treat This Devastating Viral illness Caused by The SARS-CoV-2 - The Causative Virus of Covid-19.
▫️A Preprint Version of The Study Is Available on The bioRxiv Server, While The Article Undergoes Peer-Review.
@MedicalNoteBook
bioRxiv
Probenecid Inhibits SARS-CoV-2 Replication In Vivo and In Vitro
Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show probenecid potently…
Study Confirms Longer-Term Lung Damage After Covid-19
▫️In A Paper Published In Radiology, The World's Leading Radiology Journal, The Researchers from The University of Oxford And University of Sheffield Said That Hyperpolarised Xenon MRI (XeMRI) Scans Had found Abnormalities In The Lungs of Some Covid-19 Patients More Than Three Months - And In Some Cases, Nine Months - After Leaving Hospital, When Other Clinical Measurements Were Normal.
@MedicalNoteBook
▫️In A Paper Published In Radiology, The World's Leading Radiology Journal, The Researchers from The University of Oxford And University of Sheffield Said That Hyperpolarised Xenon MRI (XeMRI) Scans Had found Abnormalities In The Lungs of Some Covid-19 Patients More Than Three Months - And In Some Cases, Nine Months - After Leaving Hospital, When Other Clinical Measurements Were Normal.
@MedicalNoteBook
pubs.rsna.org
Hyperpolarized 129Xe MRI Abnormalities in Dyspneic Participants 3 Months after COVID-19 Pneumonia: Preliminary Results | Radiology
Background SARS-CoV-2 targets angiotensin-converting enzyme 2 (ACE2) expressing cells in the respiratory tract. There are reports of breathlessness in patients many months post-infection. Purpose T...
Methotrexate Users Have A Reduced Immune Response To mRNA Covid-19 Vaccine
▫️Up To A Third of Patients Taking Methotrexate - A Common Treatment for Immune Mediated Inflammatory Conditions Such As Rheumatoid Arthritis And Psoriasis/Psoriatic Arthritis - Failed To Achieve An Adequate Immune Response To mRNA Covid-19 Vaccines In A Small Study Accepted for Publication In The Journal Annals of Rheumatic Diseases.
@MedicalNoteBook
▫️Up To A Third of Patients Taking Methotrexate - A Common Treatment for Immune Mediated Inflammatory Conditions Such As Rheumatoid Arthritis And Psoriasis/Psoriatic Arthritis - Failed To Achieve An Adequate Immune Response To mRNA Covid-19 Vaccines In A Small Study Accepted for Publication In The Journal Annals of Rheumatic Diseases.
@MedicalNoteBook
Annals of the Rheumatic Diseases
Methotrexate hampers immunogenicity to BNT162b2 mRNA COVID-19 vaccine in immune-mediated inflammatory disease
Jose U Scher, Methotrexate hampers immunogenicity to BNT162b2 mRNA COVID-19 vaccine in immune-mediated inflammatory disease. Ann Rheum Dis 2021
This is the …
This is the …
The Viruses In Our Genes: When Activated, They Damage Brain Development
▫️New Research Shows That Activation of Distinct Human Endogenous Retroviruses, Which Are Part of Our Genome, Impair Brain Development Dramatically. The Finding Could Help To Advance Research Into Therapies for Neurodegenerative Diseases.
▫️In Fact, Humans Possess Five Times More "Human Endogenous Retroviruses, Or HERVs" In Non-Coding Parts Than Coding Genes. So far, Strong focus Has Been Devoted To The Correlation of HERVs And The Onset Or Progression of Diseases.
@MedicalNewsToday
▫️New Research Shows That Activation of Distinct Human Endogenous Retroviruses, Which Are Part of Our Genome, Impair Brain Development Dramatically. The Finding Could Help To Advance Research Into Therapies for Neurodegenerative Diseases.
▫️In Fact, Humans Possess Five Times More "Human Endogenous Retroviruses, Or HERVs" In Non-Coding Parts Than Coding Genes. So far, Strong focus Has Been Devoted To The Correlation of HERVs And The Onset Or Progression of Diseases.
@MedicalNewsToday
Sciencedirect
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3
The biological function and disease association of human endogenous retroviruses (HERVs) are largely elusive. HERV-K(HML-2) has been associated with n…
Immune System May Never Forget Mild Covid-19
▫️Months After Recovery from Mild Covid-19, When Antibody Levels In The Blood Have Declined, Immune Cells In Bone Marrow Remain Ready To Pump Out New Antibodies Against The Coronavirus, Researchers Reported on Monday In Nature.
▫️Months After Recovering from Mild Cases of Covid-19, People Still Have Immune Cells In Their Body Pumping Out Antibodies Against The Virus That Causes Covid-19, According To A Study from Researchers At Washington University School of Medicine in St. Louis.
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▫️Months After Recovery from Mild Covid-19, When Antibody Levels In The Blood Have Declined, Immune Cells In Bone Marrow Remain Ready To Pump Out New Antibodies Against The Coronavirus, Researchers Reported on Monday In Nature.
▫️Months After Recovering from Mild Cases of Covid-19, People Still Have Immune Cells In Their Body Pumping Out Antibodies Against The Virus That Causes Covid-19, According To A Study from Researchers At Washington University School of Medicine in St. Louis.
@MedicalNoteBook
Nature
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans
This is an unedited manuscript that has been accepted for publication. Nature Research are providing this early version of the manuscript as a service to our authors and readers. The manuscript will undergo copyediting, typesetting and a proof review before…
Covid-19 Virus Variants Seen More Often In Young U.S. Children
▫️Young Children Appear To Be Significant Carriers of More Contagious Variants of The New Coronavirus, Such As The Ones Identified In The UK And In California, According To A New U.S. Study.
▫️From March 2020 To April 2021, Researchers At Nine Children's Hospitals Tested A Total of 2,119 Covid-19 Patients Age 18 Or Younger for So-Called Variants of Concern, Along With Key Mutations That Help The Variants Become More Contagious Or Hide From The Patient's Immune System.
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▫️Young Children Appear To Be Significant Carriers of More Contagious Variants of The New Coronavirus, Such As The Ones Identified In The UK And In California, According To A New U.S. Study.
▫️From March 2020 To April 2021, Researchers At Nine Children's Hospitals Tested A Total of 2,119 Covid-19 Patients Age 18 Or Younger for So-Called Variants of Concern, Along With Key Mutations That Help The Variants Become More Contagious Or Hide From The Patient's Immune System.
@MedicalNoteBook
medRxiv
Emergence of SARS-CoV-2 variants of concern in the pediatric population of the United States
The evolution of SARS-CoV2 virus has led to the emergence of variants of concern (VOC). Children, particularly <12 years old not yet eligible for vaccines, continue to be important reservoirs of SARS-CoV-2 yet VOC prevalence data in this population is lacking.…
Belgium Halts Johnson & Johnson’s Covid-19 Vaccine for Under 41s After First EU Death
▫️Belgium Said on Wednesday It Was Suspending Vaccinations With Johnson & Johnson’s Janssen Covid-19 Vaccine for People Under The Age of 41 Following The First Death In Europe from Severe Side-Effects Associated With The Shot.
▫️The Woman Died on May 21 After Being Admitted To Hospital With Severe Thrombosis And Platelet deficiency.
- She Was Vaccinated Through Her Employer, Outside of The Official Belgian Vaccination Campaign.
▫️“The Inter-Ministerial Conference Has Decided To Temporarily Administer Janssen’s Vaccine To The General Population from The Age of 41 Years, Pending A More Detailed Benefit-Risk Analysis by The European Medicines Agency (EMA),” Belgium’s Health Minister Said In A Statement.
▫️Belgium Has So Far Administered About 40,000 J&J Shots, With 80% of Those To People Over 45 Years Old, The Statement Said.
▫️The EMA Said More Than 1.34 Million J&J doses Had Been Administered Within The EU.
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▫️Belgium Said on Wednesday It Was Suspending Vaccinations With Johnson & Johnson’s Janssen Covid-19 Vaccine for People Under The Age of 41 Following The First Death In Europe from Severe Side-Effects Associated With The Shot.
▫️The Woman Died on May 21 After Being Admitted To Hospital With Severe Thrombosis And Platelet deficiency.
- She Was Vaccinated Through Her Employer, Outside of The Official Belgian Vaccination Campaign.
▫️“The Inter-Ministerial Conference Has Decided To Temporarily Administer Janssen’s Vaccine To The General Population from The Age of 41 Years, Pending A More Detailed Benefit-Risk Analysis by The European Medicines Agency (EMA),” Belgium’s Health Minister Said In A Statement.
▫️Belgium Has So Far Administered About 40,000 J&J Shots, With 80% of Those To People Over 45 Years Old, The Statement Said.
▫️The EMA Said More Than 1.34 Million J&J doses Had Been Administered Within The EU.
@MedicalNoteBook
European Medicines Agency Reviewing Woman's Death In Belgium After Getting Johnson & Johnson’s Covid-19 Vaccine
▫️The European Union’s Drug Regulator Said on Wednesday It Is Reviewing The Death of A Woman In Belgium Who Suffered A Blood Clot And Low Platelets After Receiving Johnson & Johnson’s Covid-19 Vaccine.
▫️The European Medicines Agency (EMA) Said It Has Asked The U.S. Drugmaker To Carry Out A Series of Additional Studies To Help Assess A Possible Link Between The Shot And A Rare Clotting Condition Known As Thrombosis With Thrombocytopenia Syndrome (TTS).
▫️It Said It Is Reviewing The Case In Belgium With Other Reports of Blood Clots With The Belgian And Slovenian Medicines Agencies.
@MedicalNoteBook
▫️The European Union’s Drug Regulator Said on Wednesday It Is Reviewing The Death of A Woman In Belgium Who Suffered A Blood Clot And Low Platelets After Receiving Johnson & Johnson’s Covid-19 Vaccine.
▫️The European Medicines Agency (EMA) Said It Has Asked The U.S. Drugmaker To Carry Out A Series of Additional Studies To Help Assess A Possible Link Between The Shot And A Rare Clotting Condition Known As Thrombosis With Thrombocytopenia Syndrome (TTS).
▫️It Said It Is Reviewing The Case In Belgium With Other Reports of Blood Clots With The Belgian And Slovenian Medicines Agencies.
@MedicalNoteBook