Associations between specific #autoimmune diseases and subsequent #dementia: retrospective record-linkage cohort study, UK

http://jech.bmj.com/content/early/2017/01/30/jech-2016-2078

The associations with vascular dementia may be one component of a broader association between autoimmune diseases and vascular damage. Though findings were significant, effect sizes were small. Clinicians should be aware of the possible coexistence of autoimmune disease and dementia in individuals. Further studies are needed to confirm or refute our findings and to explore possible mechanisms mediating any elevation of risk.

What is your Medical Specialty?

Others – 5
👍👍👍👍👍👍👍 33%

Internal Medicine – 3
👍👍👍👍 20%

Anesthesiology – 2
👍👍👍 13%

Nephrology – 2
👍👍👍 13%

Gastroenterology – 2
👍👍👍 13%

Cardiology – 1
👍 7%

Pneumology
▫️ 0%

Endocrinology
▫️ 0%

Neurology
▫️ 0%

Infectivology
▫️ 0%

👥 15 people voted so far.

Impact of #physical activity on the association of overweight and obesity with #cardiovascular disease: The Rotterdam Study

http://journals.sagepub.com/doi/10.1177/2047487317693952

Our findings suggest that the beneficial impact of physical activity on CVD might outweigh the negative impact of body mass index among middle-aged and elderly people. This emphasizes the importance of physical activity for everyone across all body mass index strata, while highlighting the risk associated with inactivity even among normal weight people.

Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance and colonisation

http://onlinelibrary.wiley.com/doi/10.1111/1462-2920.13686/abstract

Our data show that exposure to black carbon induces structural, compositional and functional changes in the biofilms of both S. pneumoniae and S. aureus.Additionally, our results show that black carbon impacts bacterial colonisation in vivo. In a mouse nasopharyngeal colonisation model, black carbon caused S. pneumoniae to spread from the nasopharynx to the lungs, which is essential for subsequent infection. Therefore our study highlights that air pollution has a significant effect on bacteria that has been largely overlooked. Consequently these findings have important implications concerning the impact of air pollution on human health and bacterial ecosystems worldwide

Liked the pic?

#Sleep characteristics modify the association of genetic predisposition with #obesity and anthropometric measurements in 119,679 UK Biobank participants http://m.ajcn.nutrition.org/content/early/2017/03/01/ajcn.116.147231those who slept for under 7 hours each night were around 2 kilograms heavier than those who slept for 7-9 hours, while adults who slept for more than 9 hours per night were around 4 kilograms heavier.

Adults who worked shifts or took naps during the day were also more likely to carry excess weightThis study shows that the association between genetic risk for obesity and phenotypic adiposity measures is exacerbated by adverse sleeping characteristics.

Vitamin #D supplementation to prevent acute #respiratory tract infections: systematic review and meta-analysis of individual participant data

http://www.bmj.com/content/356/bmj.i6583

Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit

Association Between #Migraine and Cervical Artery #Dissection
The Italian Project on #Stroke in Young Adults

http://jamanetwork.com/journals/jamaneurology/fullarticle/2606444

In this cohort study of 2485 patients aged 18 to 45 years with first-ever acute ischemic stroke, a history of migraine, especially the subtype without aura, was independently associated with cervical artery dissection. The strength of this association was higher in men and in younger individuals.

Meaning In young patients with ischemic stroke, migraine is consistently associated with cervical artery dissection. This finding implicates possible common biologic mechanisms underlying the 2 disorders

Effectiveness and Safety of #Dabigatran, #Rivaroxaban, and #Apixaban Versus Warfarin in Nonvalvular Atrial #Fibrillation

http://jaha.ahajournals.org/content/5/6/e003725

In patients with nonvalvular atrial fibrillation, apixaban was associated with lower risks of both stroke and major bleeding, dabigatran was associated with similar risk of stroke but lower risk of major bleeding, and rivaroxaban was associated with similar risks of both stroke and major bleeding in comparison to warfarin.

Cytokine Inhibition in Patients With Chronic Fatigue Syndrome: A Randomized Trial

http://annals.org/aim/article/2607809/cytokine-inhibition-patients-chronic-fatigue-syndrome-randomized-trial

Peripheral IL-1 inhibition using anakinra for 4 weeks does not result in a clinically significant reduction in fatigue severity in women with CFS and severe fatigue.

Bioaerosol generation by raindrops on soil

http://www.nature.com/articles/ncomms14668

Aerosolized microorganisms may play an important role in climate change, disease transmission, water and soil contaminants, and geographic migration of microbes.A single raindrop can transfer 0.01% of bacteria on the soil surface and the bacteria can survive more than one hour after the aerosol generation process. This work further reveals that bacteria transfer by rain is highly dependent on the regional soil profile and climate conditions

Human genetic and metabolite variation reveals that #methylthioadenosine is a prognostic biomarker and an inflammatory regulator in #sepsis

http://advances.sciencemag.org/content/3/3/e1602096

A machine-learning model combining MTA and other variables yielded approximately 80% accuracy (area under the curve) in predicting death. Furthermore, mice infected with Salmonella had prolonged survival when MTA was administered before infection, suggesting that manipulating MTA levels could regulate the severity of the inflammatory response. Our results demonstrate how combining genetic data, biomolecule measurements, and animal models can shape our understanding of disease and lead to new biomarkers for patient stratification and potential therapeutic targeting

methylthioadenosine (MTA)

#Mediterranean diet adherence and risk of postmenopausal #breast cancer: results of a cohort study and meta-analysis

http://onlinelibrary.wiley.com/doi/10.1002/ijc.30654/full

In meta-analyses, summary HRs for high versus low MD adherence were 0.94 for total postmenopausal breast cancer, 0.98 for ER+, 0.73 for ER− and 0.77 for ER − PR− breast cancer. Our findings support an inverse association between MD adherence and, particularly, receptor negative breast cancer. This may have important implications for prevention because of the poorer prognosis of these breast cancer subtypes.

MC4R-dependent suppression of #appetite by bone-derived #lipocalin 2

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature21697.html

Loss- and gain-of-function experiments in mice demonstrate that osteoblast-derived LCN2 maintains glucose homeostasis by inducing insulin secretion and improves glucose tolerance and insulin sensitivity. In addition, osteoblast-derived LCN2 inhibits food intake. LCN2 crosses the blood–brain barrier, binds to the melanocortin 4 receptor (MC4R) in the paraventricular and ventromedial neurons of the hypothalamus and activates an MC4R-dependent anorexigenic (appetite-suppressing) pathway. These results identify LCN2 as a bone-derived hormone with metabolic regulatory effects, which suppresses appetite in a MC4R-dependent manner, and show that the control of appetite is an endocrine function of bone.