Is an 8‐week regimen of glecaprevir/pibrentasvir sufficient for all #hepatitis C virus infected patients in the real‐world experience?
https://2medical.news/2020/12/02/is-an-8%E2%80%90week-regimen-of-glecaprevir-pibrentasvir-sufficient-for-all-hepatitis-c-virus-infected-patients-in-the-real%E2%80%90world-experience/
The revolution of the antiviral treatment of hepatitis C virus (HCV) infection resulting in higher effectiveness came with the introduction of direct‐acting antivirals with pangenotypic regimens as a final touch. Among them, the combination of glecaprevir (GLE) and pibrentasvir (PIB) provides the opportunity for shortening therapy to 8 weeks in the majority of patients. Because of still insufficient evaluation of this regimen in the real‐world …
https://2medical.news/2020/12/02/is-an-8%E2%80%90week-regimen-of-glecaprevir-pibrentasvir-sufficient-for-all-hepatitis-c-virus-infected-patients-in-the-real%E2%80%90world-experience/
The revolution of the antiviral treatment of hepatitis C virus (HCV) infection resulting in higher effectiveness came with the introduction of direct‐acting antivirals with pangenotypic regimens as a final touch. Among them, the combination of glecaprevir (GLE) and pibrentasvir (PIB) provides the opportunity for shortening therapy to 8 weeks in the majority of patients. Because of still insufficient evaluation of this regimen in the real‐world …
World Health Organization 2020 guidelines on physical #activity and #sedentary behaviour
https://2medical.news/2020/12/03/world-health-organization-2020-guidelines-on-physical-activity-and-sedentary-behaviour/
..The new guidelines address children, adolescents, adults, older adults and include new specific recommendations for pregnant and postpartum women and people living with chronic conditions or disability. All adults should undertake 150–300 min of moderate-intensity, or 75–150 min of vigorous-intensity physical activity, or some equivalent combination of moderate-intensity and vigorous-intensity aerobic physical activity, per week. Among children and adolescents, an average of 60 min/day of moderate-to-vigorous intensity aerobic …
https://2medical.news/2020/12/03/world-health-organization-2020-guidelines-on-physical-activity-and-sedentary-behaviour/
..The new guidelines address children, adolescents, adults, older adults and include new specific recommendations for pregnant and postpartum women and people living with chronic conditions or disability. All adults should undertake 150–300 min of moderate-intensity, or 75–150 min of vigorous-intensity physical activity, or some equivalent combination of moderate-intensity and vigorous-intensity aerobic physical activity, per week. Among children and adolescents, an average of 60 min/day of moderate-to-vigorous intensity aerobic …
Comparison of #gabapentin and #doxepin in the management of #uremic pruritus: A randomized crossover clinical trial
https://2medical.news/2020/12/03/comparison-of-gabapentin-and-doxepin-in-the-management-of-uremic-pruritus-a-randomized-crossover-clinical-trial/
Gabapentin and doxepin are well‐known treatments of uremic pruritus in hemodialysis patients but no head‐to‐head studies were conducted to date. The aim of this trial is to compare the efficacy and the tolerability of gabapentin and doxepin in the treatment of uremic pruritus in hemodialysis patients. A single‐blind crossover randomized trial was conducted that included hemodialysis patients with uremic pruritus. Patients were randomized to receive …
https://2medical.news/2020/12/03/comparison-of-gabapentin-and-doxepin-in-the-management-of-uremic-pruritus-a-randomized-crossover-clinical-trial/
Gabapentin and doxepin are well‐known treatments of uremic pruritus in hemodialysis patients but no head‐to‐head studies were conducted to date. The aim of this trial is to compare the efficacy and the tolerability of gabapentin and doxepin in the treatment of uremic pruritus in hemodialysis patients. A single‐blind crossover randomized trial was conducted that included hemodialysis patients with uremic pruritus. Patients were randomized to receive …
Consumption of Dried #Fruits Is Associated with Greater Intakes of Underconsumed Nutrients, Higher Total Energy Intakes, and Better Diet Quality in US Adults: A Cross-Sectional Analysis of the National Health and Nutrition Examination Survey, 2007-2016.
https://2medical.news/2020/12/04/consumption-of-dried-fruits-is-associated-with-greater-intakes-of-underconsumed-nutrients-higher-total-energy-intakes-and-better-diet-quality-in-us-adults-a-cross-sectional-analysis-of-the-nationa/
Dried fruits are shelf-stable alternatives to fresh fruit that avert common barriers to consuming fruit. Consumption of dried fruits may facilitate greater fruit consumption and contribute to better diet quality and nutrient intakes.. ..Mean ± standard error dried fruit intake was 0.04 ± 0.001 cup-equivalents and represented 3.7% of total fruit consumed. Consumers (7.2% of adults) had higher quality diets than nonconsumers (mean ± standard …
https://2medical.news/2020/12/04/consumption-of-dried-fruits-is-associated-with-greater-intakes-of-underconsumed-nutrients-higher-total-energy-intakes-and-better-diet-quality-in-us-adults-a-cross-sectional-analysis-of-the-nationa/
Dried fruits are shelf-stable alternatives to fresh fruit that avert common barriers to consuming fruit. Consumption of dried fruits may facilitate greater fruit consumption and contribute to better diet quality and nutrient intakes.. ..Mean ± standard error dried fruit intake was 0.04 ± 0.001 cup-equivalents and represented 3.7% of total fruit consumed. Consumers (7.2% of adults) had higher quality diets than nonconsumers (mean ± standard …
#Walking Volume and Speed Are Inversely Associated With Incidence of Treated #Hypertension in #Postmenopausal Women
https://2medical.news/2020/12/04/walking-volume-and-speed-are-inversely-associated-with-incidence-of-treated-hypertension-in-postmenopausal-women/
Few studies have evaluated hypertension incidence in relation to walking, which is a common physical activity among adults. We examined the association between walking and hypertension incidence in 83 435 postmenopausal women who at baseline were aged 50 to 79 years, without known hypertension, heart failure, coronary heart disease, or stroke, and reported the ability to walk at least one block without assistance. Walking volume (metabolic …
https://2medical.news/2020/12/04/walking-volume-and-speed-are-inversely-associated-with-incidence-of-treated-hypertension-in-postmenopausal-women/
Few studies have evaluated hypertension incidence in relation to walking, which is a common physical activity among adults. We examined the association between walking and hypertension incidence in 83 435 postmenopausal women who at baseline were aged 50 to 79 years, without known hypertension, heart failure, coronary heart disease, or stroke, and reported the ability to walk at least one block without assistance. Walking volume (metabolic …
Association of #Sedentary Time and Incident Heart #Failure Hospitalization in Postmenopausal Women
https://2medical.news/2020/12/05/association-of-sedentary-time-and-incident-heart-failure-hospitalization-in-postmenopausal-women/
Background: The 2018 US Physical Activity Guidelines recommend reducing sedentary behavior (SB) for cardiovascular health. SB’s role in heart failure (HF) is unclear. Methods: We studied 80 982 women in the Women’s Health Initiative Observational Study, aged 50 to 79 years, who were without known HF and reported ability to walk ≥1 block unassisted at baseline. Mean follow-up was 9 years for physician-adjudicated incident HF …
https://2medical.news/2020/12/05/association-of-sedentary-time-and-incident-heart-failure-hospitalization-in-postmenopausal-women/
Background: The 2018 US Physical Activity Guidelines recommend reducing sedentary behavior (SB) for cardiovascular health. SB’s role in heart failure (HF) is unclear. Methods: We studied 80 982 women in the Women’s Health Initiative Observational Study, aged 50 to 79 years, who were without known HF and reported ability to walk ≥1 block unassisted at baseline. Mean follow-up was 9 years for physician-adjudicated incident HF …
Options to Reduce #Quarantine for Contacts of Persons with SARS-#CoV-2 Infection Using Symptom Monitoring and Diagnostic Testing
https://2medical.news/2020/12/05/options-to-reduce-quarantine-for-contacts-of-persons-with-sars-cov-2-infection-using-symptom-monitoring-and-diagnostic-testing/
Local public health authorities determine and establish the quarantine options for their jurisdictions. CDC currently recommends a quarantine period of 14 days. However, based on local circumstances and resources, the following options to shorten quarantine are acceptable alternatives. Quarantine can end after Day 10 without testing and if no symptoms have been reported during daily monitoring. With this strategy, residual post-quarantine transmission risk is estimated …
https://2medical.news/2020/12/05/options-to-reduce-quarantine-for-contacts-of-persons-with-sars-cov-2-infection-using-symptom-monitoring-and-diagnostic-testing/
Local public health authorities determine and establish the quarantine options for their jurisdictions. CDC currently recommends a quarantine period of 14 days. However, based on local circumstances and resources, the following options to shorten quarantine are acceptable alternatives. Quarantine can end after Day 10 without testing and if no symptoms have been reported during daily monitoring. With this strategy, residual post-quarantine transmission risk is estimated …
Domestic #Travel During #COVID-19
https://2medical.news/2020/12/06/domestic-travel-during-covid-19/
Before You Consider Traveling Travel can increase your chance of spreading and getting COVID-19. Postponing travel and staying home is the best way to protect yourself and others from COVID-19. If you are considering traveling, here are some important questions to ask yourself and your loved ones beforehand. These questions can help you decide what is best for you and your family. Are you, someone …
https://2medical.news/2020/12/06/domestic-travel-during-covid-19/
Before You Consider Traveling Travel can increase your chance of spreading and getting COVID-19. Postponing travel and staying home is the best way to protect yourself and others from COVID-19. If you are considering traveling, here are some important questions to ask yourself and your loved ones beforehand. These questions can help you decide what is best for you and your family. Are you, someone …
#Menopause Transition and #Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association
https://2medical.news/2020/12/06/menopause-transition-and-cardiovascular-disease-risk-implications-for-timing-of-early-prevention-a-scientific-statement-from-the-american-heart-association/
Cardiovascular disease (CVD) is the leading cause of death in women, who have a notable increase in the risk for this disease after menopause and typically develop coronary heart disease several years later than men. This observation led to the hypothesis that the menopause transition (MT) contributes to the increase in coronary heart disease risk. Over the past 20 years, longitudinal studies of women traversing …
https://2medical.news/2020/12/06/menopause-transition-and-cardiovascular-disease-risk-implications-for-timing-of-early-prevention-a-scientific-statement-from-the-american-heart-association/
Cardiovascular disease (CVD) is the leading cause of death in women, who have a notable increase in the risk for this disease after menopause and typically develop coronary heart disease several years later than men. This observation led to the hypothesis that the menopause transition (MT) contributes to the increase in coronary heart disease risk. Over the past 20 years, longitudinal studies of women traversing …
Managing #Asthma in Adolescents and Adults 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program
https://2medical.news/2020/12/07/managing-asthma-in-adolescents-and-adults-2020-asthma-guideline-update-from-the-national-asthma-education-and-prevention-program/
Asthma is a major public health problem worldwide and is associated with excess morbidity, mortality, and economic costs associated with lost productivity. The National Asthma Education and Prevention Program has released the 2020 Asthma Guideline Update with updated evidence-based recommendations for treatment of patients with asthma.. ..From 20 572 identified references, 475 were included in the 6 systematic reviews to form the evidence basis for these …
https://2medical.news/2020/12/07/managing-asthma-in-adolescents-and-adults-2020-asthma-guideline-update-from-the-national-asthma-education-and-prevention-program/
Asthma is a major public health problem worldwide and is associated with excess morbidity, mortality, and economic costs associated with lost productivity. The National Asthma Education and Prevention Program has released the 2020 Asthma Guideline Update with updated evidence-based recommendations for treatment of patients with asthma.. ..From 20 572 identified references, 475 were included in the 6 systematic reviews to form the evidence basis for these …
#Older age does not influence the success of #weight loss through the implementation of lifestyle modification
https://2medical.news/2020/12/07/older-age-does-not-influence-the-success-of-weight-loss-through-the-implementation-of-lifestyle-modification/
Age is sometimes a barrier for acceptance of patients into a hospital‐based obesity service. Our aim was to explore the effect of age on the ability to lose weight through lifestyle interventions, implemented within a hospital‐based obesity service.. Primary outcome measures were percentage weight loss (%WL) and percentage reduction in body mass index (%rBMI) following implemented lifestyle interventions. Data were stratified according to patient age …
https://2medical.news/2020/12/07/older-age-does-not-influence-the-success-of-weight-loss-through-the-implementation-of-lifestyle-modification/
Age is sometimes a barrier for acceptance of patients into a hospital‐based obesity service. Our aim was to explore the effect of age on the ability to lose weight through lifestyle interventions, implemented within a hospital‐based obesity service.. Primary outcome measures were percentage weight loss (%WL) and percentage reduction in body mass index (%rBMI) following implemented lifestyle interventions. Data were stratified according to patient age …
Lifetime perspective on #alcohol and #brain health
https://2medical.news/2020/12/08/lifetime-perspective-on-alcohol-and-brain-health/
Harm prevention policies must take the long view The maintenance of brain health is central to health and wellbeing across the lifespan.1 Evidence suggests three periods of dynamic brain changes that may be particularly sensitive to the neurotoxic effects of alcohol: gestation (from conception to birth), later adolescence (15-19 years), and older adulthood (over 65 years). Highly prevalent patterns of alcohol use may cause harm …
https://2medical.news/2020/12/08/lifetime-perspective-on-alcohol-and-brain-health/
Harm prevention policies must take the long view The maintenance of brain health is central to health and wellbeing across the lifespan.1 Evidence suggests three periods of dynamic brain changes that may be particularly sensitive to the neurotoxic effects of alcohol: gestation (from conception to birth), later adolescence (15-19 years), and older adulthood (over 65 years). Highly prevalent patterns of alcohol use may cause harm …
Blood #Pressure Changes in 1610 Subjects With and Without Antihypertensive Medication During Long‐Term #Fasting
https://2medical.news/2020/12/08/blood-pressure-changes-in-1610-subjects-with-and-without-antihypertensive-medication-during-long%E2%80%90term-fasting/
We investigated daily blood pressure (BP) changes during fasting periods ranging from 4 to 41 (10.0±3.8) days in a cohort of 1610 subjects, including 920 normotensive, 313 hypertensive nonmedicated, and 377 hypertensive medicated individuals. Methods and Results Subjects underwent a multidisciplinary fasting program with a daily intake of ≈250 kcal. Weight and stress scores decreased during fasting, and the well‐being index increased, documenting a good …
https://2medical.news/2020/12/08/blood-pressure-changes-in-1610-subjects-with-and-without-antihypertensive-medication-during-long%E2%80%90term-fasting/
We investigated daily blood pressure (BP) changes during fasting periods ranging from 4 to 41 (10.0±3.8) days in a cohort of 1610 subjects, including 920 normotensive, 313 hypertensive nonmedicated, and 377 hypertensive medicated individuals. Methods and Results Subjects underwent a multidisciplinary fasting program with a daily intake of ≈250 kcal. Weight and stress scores decreased during fasting, and the well‐being index increased, documenting a good …
Older Adults and the Mental Health Effects of #COVID-19
https://2medical.news/2020/12/09/older-adults-and-the-mental-health-effects-of-covid-19/
As the coronavirus disease 2019 (COVID-19) began to spread in the US in early 2020, older adults experienced disproportionately greater adverse effects from the pandemic including more severe complications, higher mortality, concerns about disruptions to their daily routines and access to care, difficulty in adapting to technologies like telemedicine, and concerns that isolation would exacerbate existing mental health conditions. Older adults tend to have lower …
https://2medical.news/2020/12/09/older-adults-and-the-mental-health-effects-of-covid-19/
As the coronavirus disease 2019 (COVID-19) began to spread in the US in early 2020, older adults experienced disproportionately greater adverse effects from the pandemic including more severe complications, higher mortality, concerns about disruptions to their daily routines and access to care, difficulty in adapting to technologies like telemedicine, and concerns that isolation would exacerbate existing mental health conditions. Older adults tend to have lower …
#Cognitive decline in older adults with #epilepsy: The Cardiovascular Health Study
https://2medical.news/2020/12/09/cognitive-decline-in-older-adults-with-epilepsy-the-cardiovascular-health-study/
Cognitive decline is a major concern for older adults with epilepsy. Whether and how much faster older adults with epilepsy experience cognitive decline beyond expected age‐related cognitive change remain unclear. We sought to estimate and compare rates of cognitive decline in older adults with and without epilepsy.. ..The rate of decline in 3MS was significantly faster in prevalent epilepsy (P < .001) and after incident …
https://2medical.news/2020/12/09/cognitive-decline-in-older-adults-with-epilepsy-the-cardiovascular-health-study/
Cognitive decline is a major concern for older adults with epilepsy. Whether and how much faster older adults with epilepsy experience cognitive decline beyond expected age‐related cognitive change remain unclear. We sought to estimate and compare rates of cognitive decline in older adults with and without epilepsy.. ..The rate of decline in 3MS was significantly faster in prevalent epilepsy (P < .001) and after incident …
Incidence rates of severe #cutaneous adverse reactions due to anti #seizure medication: A nationwide study using health claims data in Korea
https://2medical.news/2020/12/10/incidence-rates-of-severe-cutaneous-adverse-reactions-due-to-anti-seizure-medication-a-nationwide-study-using-health-claims-data-in-korea/
Antiseizure medications (ASMs) can rarely result in severe, sometimes fatal, cutaneous adverse reactions. To date, few studies have reported on the incidence rates (IRs) of severe cutaneous adverse reactions (SCARs) due to ASM use. This study aimed to determine the IRs of SCAR resulting from the use of seven commonly prescribed ASMs, carbamazepine (CBZ), phenytoin (PHT), oxcarbazepine (OXC), lamotrigine (LMT), zonisamide (ZNS), levetiracetam (LVT), and …
https://2medical.news/2020/12/10/incidence-rates-of-severe-cutaneous-adverse-reactions-due-to-anti-seizure-medication-a-nationwide-study-using-health-claims-data-in-korea/
Antiseizure medications (ASMs) can rarely result in severe, sometimes fatal, cutaneous adverse reactions. To date, few studies have reported on the incidence rates (IRs) of severe cutaneous adverse reactions (SCARs) due to ASM use. This study aimed to determine the IRs of SCAR resulting from the use of seven commonly prescribed ASMs, carbamazepine (CBZ), phenytoin (PHT), oxcarbazepine (OXC), lamotrigine (LMT), zonisamide (ZNS), levetiracetam (LVT), and …
Post-lockdown SARS- #CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China
https://2medical.news/2020/12/10/post-lockdown-sars-cov-2-nucleic-acid-screening-in-nearly-ten-million-residents-of-wuhan-china/
Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No …
https://2medical.news/2020/12/10/post-lockdown-sars-cov-2-nucleic-acid-screening-in-nearly-ten-million-residents-of-wuhan-china/
Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No …
Assessment of Physician #Sleep and Wellness, #Burnout, and Clinically Significant Medical Errors
https://2medical.news/2020/12/11/assessment-of-physician-sleep-and-wellness-burnout-and-clinically-significant-medical-errors/
Sleep-related impairment in physicians is an occupational hazard associated with long and sometimes unpredictable work hours and may contribute to burnout and self-reported clinically significant medical error.. ..Of all physicians invited to participate in the survey, 7700 of 19 384 attending physicians (40%) and 3695 of 7257 house staff physicians (51%) completed sleep-related impairment items, including 5279 women (46%), 5187 men (46%), and 929 (8%) who …
https://2medical.news/2020/12/11/assessment-of-physician-sleep-and-wellness-burnout-and-clinically-significant-medical-errors/
Sleep-related impairment in physicians is an occupational hazard associated with long and sometimes unpredictable work hours and may contribute to burnout and self-reported clinically significant medical error.. ..Of all physicians invited to participate in the survey, 7700 of 19 384 attending physicians (40%) and 3695 of 7257 house staff physicians (51%) completed sleep-related impairment items, including 5279 women (46%), 5187 men (46%), and 929 (8%) who …
Vitamin #D metabolites and the gut #microbiome in older men
https://2medical.news/2020/12/11/vitamin-d-metabolites-and-the-gut-microbiome-in-older-men/
The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression. With current limited understanding of the interactions between the gut microbiome and vitamin D, we conduct a cross-sectional analysis of 567 older men quantifying serum vitamin D metabolites using LC-MSMS and defining stool sub-Operational Taxonomic Units from16S ribosomal RNA gene sequencing data. Faith’s Phylogenetic Diversity and non-redundant covariate analyses …
https://2medical.news/2020/12/11/vitamin-d-metabolites-and-the-gut-microbiome-in-older-men/
The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression. With current limited understanding of the interactions between the gut microbiome and vitamin D, we conduct a cross-sectional analysis of 567 older men quantifying serum vitamin D metabolites using LC-MSMS and defining stool sub-Operational Taxonomic Units from16S ribosomal RNA gene sequencing data. Faith’s Phylogenetic Diversity and non-redundant covariate analyses …
#Cooking as a Health Behavior: Examining the Role of Cooking Classes in a #Weight Loss Intervention
https://2medical.news/2020/12/12/cooking-as-a-health-behavior-examining-the-role-of-cooking-classes-in-a-weight-loss-intervention/
Americans are cooking fewer meals at home and eating more convenience foods prepared elsewhere. Cooking at home is associated with higher quality diets, while a reduction in cooking may be associated with increases in obesity and risk factors for chronic disease. The aims of this study were to examine cooking as an intervention for weight control in overweight and obese adults, and whether such an …
https://2medical.news/2020/12/12/cooking-as-a-health-behavior-examining-the-role-of-cooking-classes-in-a-weight-loss-intervention/
Americans are cooking fewer meals at home and eating more convenience foods prepared elsewhere. Cooking at home is associated with higher quality diets, while a reduction in cooking may be associated with increases in obesity and risk factors for chronic disease. The aims of this study were to examine cooking as an intervention for weight control in overweight and obese adults, and whether such an …
#EPA and #DHA differentially modulate monocyte #inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study
https://2medical.news/2020/12/12/epa-and-dha-differentially-modulate-monocyte-inflammatory-response-in-subjects-with-chronic-inflammation-in-part-via-plasma-specialized-pro-resolving-lipid-mediators-a-randomized-double-blind-cr/
The independent effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on chronic inflammation through their downstream lipid mediators, including the specialized pro-resolving lipid mediators (SPM), remain unstudied. Therefore, we compared the effects of EPA and DHA supplementation on monocyte inflammatory response and plasma polyunsaturated fatty acids (PUFA) SPM lipidome.. After a 4-week lead-in phase (baseline), 9 men and 12 postmenopausal women (50–75 years) with …
https://2medical.news/2020/12/12/epa-and-dha-differentially-modulate-monocyte-inflammatory-response-in-subjects-with-chronic-inflammation-in-part-via-plasma-specialized-pro-resolving-lipid-mediators-a-randomized-double-blind-cr/
The independent effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on chronic inflammation through their downstream lipid mediators, including the specialized pro-resolving lipid mediators (SPM), remain unstudied. Therefore, we compared the effects of EPA and DHA supplementation on monocyte inflammatory response and plasma polyunsaturated fatty acids (PUFA) SPM lipidome.. After a 4-week lead-in phase (baseline), 9 men and 12 postmenopausal women (50–75 years) with …