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Physical #activity, common #brain pathologies, and cognition in community-dwelling older adults
http://n.neurology.org/content/early/2019/01/16/WNL.0000000000006954
Higher levels of total daily activity (estimate 0.148, 95% confidence interval 0.053–0.0.244, SE 0.049, p = 0.003) and better motor abilities (estimate 0.283, 95% confidence interval, 0.175–0.390, SE 0.055, p < 0.001) were independently associated with better cognition. These independent associations remained significant when terms for AD and other pathologies were added as well as in sensitivity analyses excluding cases with poor cognition or dementia. Adding interaction terms, the associations of total daily activity and motor abilities with cognition did not vary in individuals with and without dementia. The associations of AD and other pathologies with cognition did not vary with the levels of total daily activity or motor abilities.
Conclusions Physical activity in older adults may provide cognitive reserve to maintain function independent of the accumulation of diverse brain pathologies. Further studies are needed to identify the molecular mechanisms underlying this potential reserve and to ensure the causal effects of physical activity.
Physical #activity, common #brain pathologies, and cognition in community-dwelling older adults
http://n.neurology.org/content/early/2019/01/16/WNL.0000000000006954
Higher levels of total daily activity (estimate 0.148, 95% confidence interval 0.053–0.0.244, SE 0.049, p = 0.003) and better motor abilities (estimate 0.283, 95% confidence interval, 0.175–0.390, SE 0.055, p < 0.001) were independently associated with better cognition. These independent associations remained significant when terms for AD and other pathologies were added as well as in sensitivity analyses excluding cases with poor cognition or dementia. Adding interaction terms, the associations of total daily activity and motor abilities with cognition did not vary in individuals with and without dementia. The associations of AD and other pathologies with cognition did not vary with the levels of total daily activity or motor abilities.
Conclusions Physical activity in older adults may provide cognitive reserve to maintain function independent of the accumulation of diverse brain pathologies. Further studies are needed to identify the molecular mechanisms underlying this potential reserve and to ensure the causal effects of physical activity.
Neurology
Physical activity, common brain pathologies, and cognition in community-dwelling older adults
Objective To examine the associations of physical activity, Alzheimer disease (AD), and other brain pathologies and cognition in older adults.
Methods We studied 454 brain autopsies from decedents in a clinical-pathologic cohort study. Nineteen cognitive…
Methods We studied 454 brain autopsies from decedents in a clinical-pathologic cohort study. Nineteen cognitive…
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Detection of Brain Activation in Unresponsive Patients with Acute #Brain #Injury
https://lnkd.in/dUB9c9F
Brain activation in response to spoken motor commands can be detected by electroencephalography (EEG) in clinically unresponsive patients.
A total of 16 of 104 unresponsive patients (15%) had brain activation detected by EEG at a median of 4 days after injury. The condition in 8 of these 16 patients (50%) and in 23 of 88 patients (26%) without brain activation improved such that they were able to follow commands before discharge. At 12 months, 7 of 16 patients (44%) with brain activation and 12 of 84 patients (14%) without brain activation had a GOS-E level of 4 or higher, denoting the ability to function independently for 8 hours (odds ratio, 4.6; 95% confidence interval, 1.2 to 17.1).
CONCLUSIONS
A dissociation between the absence of behavioral responses to motor commands and the evidence of brain activation in response to these commands in EEG recordings was found in 15% of patients in a consecutive series of patients with acute brain injury.
Detection of Brain Activation in Unresponsive Patients with Acute #Brain #Injury
https://lnkd.in/dUB9c9F
Brain activation in response to spoken motor commands can be detected by electroencephalography (EEG) in clinically unresponsive patients.
A total of 16 of 104 unresponsive patients (15%) had brain activation detected by EEG at a median of 4 days after injury. The condition in 8 of these 16 patients (50%) and in 23 of 88 patients (26%) without brain activation improved such that they were able to follow commands before discharge. At 12 months, 7 of 16 patients (44%) with brain activation and 12 of 84 patients (14%) without brain activation had a GOS-E level of 4 or higher, denoting the ability to function independently for 8 hours (odds ratio, 4.6; 95% confidence interval, 1.2 to 17.1).
CONCLUSIONS
A dissociation between the absence of behavioral responses to motor commands and the evidence of brain activation in response to these commands in EEG recordings was found in 15% of patients in a consecutive series of patients with acute brain injury.
New England Journal of Medicine
Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury | NEJM
Original Article from The New England Journal of Medicine — Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury
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Effects of #tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic #brain injury (CRASH-3): a randomised, placebo-controlled trial
Tranexamic acid reduces surgical bleeding and decreases mortality in patients with traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury (TBI) and can cause brain herniation and death. We aimed to assess the effects of tranexamic acid in patients with TBI.
The risk of head injury-related death reduced with tranexamic acid in patients with mild-to-moderate head injury (RR 0·78 [95% CI 0·64–0·95]) but not in patients with severe head injury (0·99 [95% CI 0·91–1·07]; p value for heterogeneity 0·030). Early treatment was more effective than was later treatment in patients with mild and moderate head injury (p=0·005) but time to treatment had no obvious effect in patients with severe head injury (p=0·73). The risk of vascular occlusive events was similar in the tranexamic acid and placebo groups (RR 0·98 (0·74–1·28). The risk of seizures was also similar between groups (1·09 [95% CI 0·90–1·33]).
Interpretation
Our results show that tranexamic acid is safe in patients with TBI and that treatment within 3 h of injury reduces head injury-related death. Patients should be treated as soon as possible after injury.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32233-0/fulltext
Effects of #tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic #brain injury (CRASH-3): a randomised, placebo-controlled trial
Tranexamic acid reduces surgical bleeding and decreases mortality in patients with traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury (TBI) and can cause brain herniation and death. We aimed to assess the effects of tranexamic acid in patients with TBI.
The risk of head injury-related death reduced with tranexamic acid in patients with mild-to-moderate head injury (RR 0·78 [95% CI 0·64–0·95]) but not in patients with severe head injury (0·99 [95% CI 0·91–1·07]; p value for heterogeneity 0·030). Early treatment was more effective than was later treatment in patients with mild and moderate head injury (p=0·005) but time to treatment had no obvious effect in patients with severe head injury (p=0·73). The risk of vascular occlusive events was similar in the tranexamic acid and placebo groups (RR 0·98 (0·74–1·28). The risk of seizures was also similar between groups (1·09 [95% CI 0·90–1·33]).
Interpretation
Our results show that tranexamic acid is safe in patients with TBI and that treatment within 3 h of injury reduces head injury-related death. Patients should be treated as soon as possible after injury.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32233-0/fulltext
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Convergent evidence for predispositional effects of #brain gray matter volume on #alcohol consumption
Smaller right dorsolateral prefrontal cortex (DLPFC; i.e., middle and superior frontal gyri) and insula GMVs were associated with increased alcohol use across samples. Family-based and prospective longitudinal data suggest these associations are genetically-conferred and that DLPFC GMV prospectively predicts future use and initiation. Genomic risk for alcohol use was enriched in gene-sets preferentially expressed in the DLPFC, and associated with replicable differential gene expression in the DLPFC.
Conclusions
These data suggest that smaller DLPFC and insula GMV plausibly represent genetically-conferred predispositional risk factors for, as opposed to consequences of, alcohol use. DLPFC and insula GMV represent promising biomarkers for alcohol consumption liability and related psychiatric and behavioral phenotypes.
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(19)31678-6/fulltext
Convergent evidence for predispositional effects of #brain gray matter volume on #alcohol consumption
Smaller right dorsolateral prefrontal cortex (DLPFC; i.e., middle and superior frontal gyri) and insula GMVs were associated with increased alcohol use across samples. Family-based and prospective longitudinal data suggest these associations are genetically-conferred and that DLPFC GMV prospectively predicts future use and initiation. Genomic risk for alcohol use was enriched in gene-sets preferentially expressed in the DLPFC, and associated with replicable differential gene expression in the DLPFC.
Conclusions
These data suggest that smaller DLPFC and insula GMV plausibly represent genetically-conferred predispositional risk factors for, as opposed to consequences of, alcohol use. DLPFC and insula GMV represent promising biomarkers for alcohol consumption liability and related psychiatric and behavioral phenotypes.
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(19)31678-6/fulltext
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Associations Between #vascular Risk Across Adulthood and #Brain Pathology in Late Life
Evidence From a British Birth Cohort
Office-based Framingham Heart study–cardiovascular risk scores (FHS-CVS) were derived at ages 36, 53, and 69 years using systolic blood pressure, antihypertensive medication usage, smoking, diabetic status, and body mass index. Analysis models adjusted for age at imaging, sex, APOE genotype, socioeconomic position, and, where appropriate, total intracranial volume.
..At all points, these scores were associated with smaller whole-brain volumes (36 years: β coefficient per 1% increase, −3.6 [95% CI, −7.0 to −0.3]; 53 years: −0.8 [95% CI, −1.5 to −0.08]; 69 years: −0.6 [95% CI, −1.1 to −0.2]) and higher white matter–hyperintensity volume (exponentiated coefficient: 36 years, 1.09 [95% CI, 1.01-1.18]; 53 years, 1.02 [95% CI, 1.00-1.04]; 69 years, 1.01 [95% CI, 1.00-1.02]), with largest effect sizes at age 36 years. At no point were FHS-CVS results associated with β-amyloid status.
Conclusions and Relevance Higher vascular risk is associated with smaller whole-brain volume and greater white matter–hyperintensity volume at age 69 to 71 years, with the strongest association seen with early adulthood vascular risk. There was no evidence that higher vascular risk influences amyloid deposition, at least up to age 71 years. Reducing vascular risk with appropriate interventions should be considered from early adulthood to maximize late-life brain health.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2753445
Associations Between #vascular Risk Across Adulthood and #Brain Pathology in Late Life
Evidence From a British Birth Cohort
Office-based Framingham Heart study–cardiovascular risk scores (FHS-CVS) were derived at ages 36, 53, and 69 years using systolic blood pressure, antihypertensive medication usage, smoking, diabetic status, and body mass index. Analysis models adjusted for age at imaging, sex, APOE genotype, socioeconomic position, and, where appropriate, total intracranial volume.
..At all points, these scores were associated with smaller whole-brain volumes (36 years: β coefficient per 1% increase, −3.6 [95% CI, −7.0 to −0.3]; 53 years: −0.8 [95% CI, −1.5 to −0.08]; 69 years: −0.6 [95% CI, −1.1 to −0.2]) and higher white matter–hyperintensity volume (exponentiated coefficient: 36 years, 1.09 [95% CI, 1.01-1.18]; 53 years, 1.02 [95% CI, 1.00-1.04]; 69 years, 1.01 [95% CI, 1.00-1.02]), with largest effect sizes at age 36 years. At no point were FHS-CVS results associated with β-amyloid status.
Conclusions and Relevance Higher vascular risk is associated with smaller whole-brain volume and greater white matter–hyperintensity volume at age 69 to 71 years, with the strongest association seen with early adulthood vascular risk. There was no evidence that higher vascular risk influences amyloid deposition, at least up to age 71 years. Reducing vascular risk with appropriate interventions should be considered from early adulthood to maximize late-life brain health.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2753445
Jamanetwork
Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life
This longitudinal cohort study assesses the associations between vascular risk in early adulthood, midlife, and late life with late-life brain structure and β-amyloid load and white matter hyperintensity, whole-brain, and hippocampal volumes.
Generative Feedback Explains Distinct #Brain Activity Codes for Seen and #Mental Images
https://2medical.news/2020/07/15/generative-feedback-explains-distinct-brain-activity-codes-for-seen-and-mental-images/
The relationship between mental imagery and vision is a long-standing problem in neuroscience. Currently, it is not known whether differences between the activity evoked during vision and reinstated during imagery reflect different codes for seen and mental images. To address this problem, we modeled mental imagery in the human brain as feedback in a hierarchical generative network. Such networks synthesize images by feeding abstract representations …
https://2medical.news/2020/07/15/generative-feedback-explains-distinct-brain-activity-codes-for-seen-and-mental-images/
The relationship between mental imagery and vision is a long-standing problem in neuroscience. Currently, it is not known whether differences between the activity evoked during vision and reinstated during imagery reflect different codes for seen and mental images. To address this problem, we modeled mental imagery in the human brain as feedback in a hierarchical generative network. Such networks synthesize images by feeding abstract representations …
2Medical.News
Generative Feedback Explains Distinct Brain Activity Codes for Seen and Mental Images
The relationship between mental imagery and vision is a long-standing problem in neuroscience. Currently, it is not known whether differences between the activity evoked during vision and reinstate…
Conservation of #brain connectivity and wiring across the mammalian class
https://2medical.news/2020/08/03/conservation-of-brain-connectivity-and-wiring-across-the-mammalian-class/
Over 100 years ago, Ramon y Cajal hypothesized that two forces played a role in the evolution of mammalian brain connectivity: minimizing wiring costs and maximizing conductivity speed. Using diffusion MRI, we reconstructed the brain connectomes of 123 mammalian species. Network analysis revealed that both connectivity and the wiring cost are conserved across mammals. We describe a conservation principle that maintains the overall connectivity: species …
https://2medical.news/2020/08/03/conservation-of-brain-connectivity-and-wiring-across-the-mammalian-class/
Over 100 years ago, Ramon y Cajal hypothesized that two forces played a role in the evolution of mammalian brain connectivity: minimizing wiring costs and maximizing conductivity speed. Using diffusion MRI, we reconstructed the brain connectomes of 123 mammalian species. Network analysis revealed that both connectivity and the wiring cost are conserved across mammals. We describe a conservation principle that maintains the overall connectivity: species …
#Language comprehension in the social #brain: Electrophysiological brain signals of social presence effects during syntactic and semantic sentence processing
https://2medical.news/2020/09/29/language-comprehension-in-the-social-brain-electrophysiological-brain-signals-of-social-presence-effects-during-syntactic-and-semantic-sentence-processing/
Although, evolutionarily, language emerged predominantly for social purposes, much has yet to be uncovered regarding how language processing is affected by social context. Social presence research studies the ways in which the presence of a conspecific affects processing, but has yet to be thoroughly applied to language processes. The principal aim of this study was to see how syntactic and semantic language processing might be …
https://2medical.news/2020/09/29/language-comprehension-in-the-social-brain-electrophysiological-brain-signals-of-social-presence-effects-during-syntactic-and-semantic-sentence-processing/
Although, evolutionarily, language emerged predominantly for social purposes, much has yet to be uncovered regarding how language processing is affected by social context. Social presence research studies the ways in which the presence of a conspecific affects processing, but has yet to be thoroughly applied to language processes. The principal aim of this study was to see how syntactic and semantic language processing might be …
Lifetime perspective on #alcohol and #brain health
https://2medical.news/2020/12/08/lifetime-perspective-on-alcohol-and-brain-health/
Harm prevention policies must take the long view The maintenance of brain health is central to health and wellbeing across the lifespan.1 Evidence suggests three periods of dynamic brain changes that may be particularly sensitive to the neurotoxic effects of alcohol: gestation (from conception to birth), later adolescence (15-19 years), and older adulthood (over 65 years). Highly prevalent patterns of alcohol use may cause harm …
https://2medical.news/2020/12/08/lifetime-perspective-on-alcohol-and-brain-health/
Harm prevention policies must take the long view The maintenance of brain health is central to health and wellbeing across the lifespan.1 Evidence suggests three periods of dynamic brain changes that may be particularly sensitive to the neurotoxic effects of alcohol: gestation (from conception to birth), later adolescence (15-19 years), and older adulthood (over 65 years). Highly prevalent patterns of alcohol use may cause harm …
BBB pathophysiology–independent delivery of siRNA in traumatic #brain injury
https://2medical.news/2021/01/03/bbb-pathophysiology-independent-delivery-of-sirna-in-traumatic-brain-injury/
Small interfering RNA (siRNA)–based therapeutics can mitigate the long-term sequelae of traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier (BBB). One approach to overcoming this challenge involves treatment administration while BBB is transiently breached after injury. However, it offers a limited window for therapeutic intervention and is applicable to only a subset of injuries with substantially breached BBB. We report …
https://2medical.news/2021/01/03/bbb-pathophysiology-independent-delivery-of-sirna-in-traumatic-brain-injury/
Small interfering RNA (siRNA)–based therapeutics can mitigate the long-term sequelae of traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier (BBB). One approach to overcoming this challenge involves treatment administration while BBB is transiently breached after injury. However, it offers a limited window for therapeutic intervention and is applicable to only a subset of injuries with substantially breached BBB. We report …
A Primary Care Agenda for #Brain Health: A Scientific Statement From the American Heart Association
https://2medical.news/2021/03/19/a-primary-care-agenda-for-brain-health-a-scientific-statement-from-the-american-heart-association/
A healthy brain is critical for living a longer and fuller life. The projected aging of the population, however, raises new challenges in maintaining quality of life. As we age, there is increasing compromise of neuronal activity that affects functions such as cognition, also making the brain vulnerable to disease. Once pathology-induced decline begins, few therapeutic options are available. Prevention is therefore paramount, and primary …
https://2medical.news/2021/03/19/a-primary-care-agenda-for-brain-health-a-scientific-statement-from-the-american-heart-association/
A healthy brain is critical for living a longer and fuller life. The projected aging of the population, however, raises new challenges in maintaining quality of life. As we age, there is increasing compromise of neuronal activity that affects functions such as cognition, also making the brain vulnerable to disease. Once pathology-induced decline begins, few therapeutic options are available. Prevention is therefore paramount, and primary …
#Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age
https://2medical.news/2021/05/10/mediterranean-diet-alzheimer-disease-biomarkers-and-brain-atrophy-in-old-age/
https://2medical.news/2021/05/10/mediterranean-diet-alzheimer-disease-biomarkers-and-brain-atrophy-in-old-age/
2Medical.News
#Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age
To determine if following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer’s disease (AD), we analyzed cross-sectional data from the German Longi…
Reduced coupling between cerebrospinal fluid flow and global #brain activity is linked to #Alzheimer disease–related pathology
https://2medical.news/2021/06/08/reduced-coupling-between-cerebrospinal-fluid-flow-and-global-brain-activity-is-linked-to-alzheimer-disease-related-pathology/
https://2medical.news/2021/06/08/reduced-coupling-between-cerebrospinal-fluid-flow-and-global-brain-activity-is-linked-to-alzheimer-disease-related-pathology/
2Medical.News
Reduced coupling between cerebrospinal fluid flow and global #brain activity is linked to #Alzheimer disease–related pathology
The glymphatic system plays an important role in clearing the amyloid-β (Aβ) and tau proteins that are closely linked to Alzheimer disease (AD) pathology. Glymphatic clearance, as well as Aβ accumu…
Regional, circuit and network heterogeneity of #brain abnormalities in #psychiatric disorders
https://2medical.news/2023/08/25/regional-circuit-and-network-heterogeneity-of-brain-abnormalities-in-psychiatric-disorders/
https://2medical.news/2023/08/25/regional-circuit-and-network-heterogeneity-of-brain-abnormalities-in-psychiatric-disorders/
2Medical.News
Regional, circuit and network heterogeneity of #brain abnormalities in #psychiatric disorders
The substantial individual heterogeneity that characterizes people with mental illness is often ignored by classical case–control research, which relies on group mean comparisons. Here we present a…
Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals
https://2medical.news/2023/09/11/visceral-and-subcutaneous-abdominal-fat-predict-brain-volume-loss-at-midlife-in-10001-individualsabstractabdominal-fat-is-increasingly-linked-to-brain-health-a-total-of-10001-healthy-participants/
https://2medical.news/2023/09/11/visceral-and-subcutaneous-abdominal-fat-predict-brain-volume-loss-at-midlife-in-10001-individualsabstractabdominal-fat-is-increasingly-linked-to-brain-health-a-total-of-10001-healthy-participants/
2Medical.News
Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals
AbstractAbdominal fat is increasingly linked to brain health. A total of 10,001 healthy participants were scanned on 1.5T MRI with a short whole-body MR imaging protocol. Deep learning with FastSur…
Effects of chronic #caffeine on patterns of #brain blood flow and behavior throughout the sleep–wake cycle in freely behaving mice
https://2medical.news/2023/10/02/effects-of-chronic-caffeine-on-patterns-of-brain-blood-flow-and-behavior-throughout-the-sleep-wake-cycle-in-freely-behaving-mice/
https://2medical.news/2023/10/02/effects-of-chronic-caffeine-on-patterns-of-brain-blood-flow-and-behavior-throughout-the-sleep-wake-cycle-in-freely-behaving-mice/
2Medical.News
Effects of chronic #caffeine on patterns of #brain blood flow and behavior throughout the sleep–wake cycle in freely behaving mice
Caffeine has significant effects on neurovascular activity and behavior throughout the sleep–wake cycle. We used a minimally invasive microchip/video system to continuously record effects of caffei…
Long-term risk of #cardiovascular disease after traumatic #brain injury: screening and prevention
https://2medical.news/2024/01/25/long-term-risk-of-cardiovascular-disease-after-traumatic-brain-injury-screening-and-prevention/
https://2medical.news/2024/01/25/long-term-risk-of-cardiovascular-disease-after-traumatic-brain-injury-screening-and-prevention/
2Medical.News
Long-term risk of #cardiovascular disease after traumatic #brain injury: screening and prevention
Traumatic brain injury (TBI) is highly prevalent among individuals participating in contact sports, military personnel, and in the general population. Although it is well known that brain injury ca…