#Meningeal γδ T cells regulate #anxiety-like behavior via IL-17a signaling in neurons
https://2medical.news/2020/09/27/meningeal-%CE%B3%CE%B4-t-cells-regulate-anxiety-like-behavior-via-il-17a-signaling-in-neurons/
Interleukin (IL)-17a has been highly conserved during evolution of the vertebrate immune system and widely studied in contexts of infection and autoimmunity. Studies suggest that IL-17a promotes behavioral changes in experimental models of autism and aggregation behavior in worms. Here, through a cellular and molecular characterization of meningeal γδ17 T cells, we defined the nearest central nervous system–associated source of IL-17a under homeostasis. Meningeal γδ …
https://2medical.news/2020/09/27/meningeal-%CE%B3%CE%B4-t-cells-regulate-anxiety-like-behavior-via-il-17a-signaling-in-neurons/
Interleukin (IL)-17a has been highly conserved during evolution of the vertebrate immune system and widely studied in contexts of infection and autoimmunity. Studies suggest that IL-17a promotes behavioral changes in experimental models of autism and aggregation behavior in worms. Here, through a cellular and molecular characterization of meningeal γδ17 T cells, we defined the nearest central nervous system–associated source of IL-17a under homeostasis. Meningeal γδ …