prolymphocytoid transformation of B-CLL.

prolymphocytoid transformation of B-CLL.

PB demonstrating many
prolymphocytes with prominent nucleolus

PB demonstrating prolymphocytes
with prominent nucleoli

BM with many prolymphocytes

PB film in prolymphocytoid
transformation of CLL.

PB film in Richter
syndrome showing residual
mature small lymphocytes and
two large, immunoblast‐like
cells

BM film in Richter
syndrome, same patient

PB film in B
prolymphocytic leukaemia (B‐PLL)
showing cells that are regular in
shape with round nuclei. Nuclear
chromatin shows some
condensation and the larger cells
contain prominent vesicular
nucl

The prolymphocyte is a large cell
with often relatively abundant cytoplasm. The
nucleus is round with relatively well‐condensed
nuclear chromatin and with a prominent vesicular nucleolus showing perinucleolar chromatin
condensation. Occasionally the cytoplasm contains globules, Auer rod‐like crystals [184] or
azurophilic granules [185], which are composed
of immunoglobulin. One patient whose cells
showed erythrophagocytic activity has been
described [186].

Evolution of B-CLL into diffuse
large B-cell lymphoma (Richter syndrome).

B-PLL

B-PLL

B-PLL

PB demonstrating hairy cells

BM with many hairy cells

Plasma cells. Note rouleaux

Plasma cells, one multinucleated

Plasmablast. with the lighter blue
cytoplasm with the indistinct hof and the slightly
eccentric nucleus with 2 distinct nucleoli

Proplasmacyte. The cytoplasm is
darker blue and the perinuclear hof is distinct. The
nucleus is eccentric and the nucleolus is partially masked
by the clumped chromatin

Flame cell. Associated with plasma
cells that are producing immunoglobulin A (IgA)