Q107. The clinical progression of gout begins with:
Anonymous Quiz
14%
A) Acute gout attacks
37%
B) Chronic tophaceous gout
49%
C) Asymptomatic hyperuricemia
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Q108. Primary gout is often associated with all the following EXCEPT:
Anonymous Quiz
20%
A) Obesity
20%
B) Alcohol
61%
C) Hypotension
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Q109. Secondary gout can be caused by:
Anonymous Quiz
11%
A) Renal failure
35%
B) Increased cell breakdown
3%
C) Certain drugs
52%
D) All of the above
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Q110. The definitive diagnosis of gout is made by observing joint fluid for:
Anonymous Quiz
1%
A) High glucose levels
97%
B) Needle-shaped, negatively birefringent crystals
2%
C) Rhomboid-shaped crystals
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Q111. Which dietary factor can increase serum urate levels?
Anonymous Quiz
3%
A) High-fiber vegetables
96%
B) Fructose-containing beverages
1%
C) Low-fat dairy
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Q112. Approximately how much of the filtered urate is reabsorbed in the proximal tubule via URAT1?
Anonymous Quiz
6%
A) 10%
39%
B) 50%
55%
C) 90%
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Q113. Which condition increases urate retention in the kidneys?
Anonymous Quiz
23%
A) Respiratory alkalosis
51%
B) Lactic acidosis
26%
C) High GFR
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Q114. Hypouricemia (low uric acid) can be caused by:
Anonymous Quiz
1%
A) Obesity
96%
B) Xanthinuria (xanthine oxidase deficiency)
2%
C) Gout
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Q115. A common complication of chronic hyperuricemia is:
Anonymous Quiz
19%
A) Liver cirrhosis
69%
B) Kidney stones
12%
C) Osteoporosis
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Q116. Each gram of Hemoglobin (Hb) contains how much iron?
Anonymous Quiz
5%
A) 1 mg
90%
B) 3.4 mg
5%
C) 10 mg
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Q117. Heme is chemically defined as a:
Anonymous Quiz
25%
A) Magnesium protoporphyrin
67%
B) Ferroprotoporphyrin
9%
C) Globulin chain
Q118. In Step 1 of heme synthesis, ALA synthase requires which cofactor?
Anonymous Quiz
3%
A) Vitamin B12
96%
B) Pyridoxal phosphate (B_6)
1%
C) Vitamin C
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Q119. ALA dehydratase, which forms PBG, is inhibited by which toxic metal?
Anonymous Quiz
8%
A) Mercury
74%
B) Lead
18%
C) Aluminium
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Q120. PBG-deaminase is the enzyme responsible for converting PBG into:
Anonymous Quiz
12%
A) ALA
9%
B) Heme
78%
C) Uroporphyrinogen III
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Q121. Uroporphyrinogen decarboxylase converts UPG-III into:
Anonymous Quiz
1%
A) Heme
4%
B) Protoporphyrin
95%
C) Coproporphyrinogen III (CPG-III)
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Q122. The conversion of CPG-III to PPG-III occurs in the mitochondria and requires:
Anonymous Quiz
43%
A) CO_2
48%
B) O_2
9%
C) Na+
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Q123. Colored porphyrins are formed during which step?
Anonymous Quiz
1%
A) Step 1
8%
B) Step 2
91%
C) Step 6 (PPG-III to PP-III)
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Q124. The final step of heme formation (PP-III + Fe2+) is catalyzed by:
Anonymous Quiz
3%
A) ALA synthase
72%
B) Ferrochelatase
26%
C) Carbonic anhydrase
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Q125. Most porphyrias are inherited in which pattern?
Anonymous Quiz
14%
A) Autosomal recessive
79%
B) Autosomal dominant
7%
C) X-linked
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Q126. Porphyrias are primarily classified into:
Anonymous Quiz
4%
A) Cardiac and Renal
93%
B) Hepatic and Erythropoietic
4%
C) Intestinal and Pulmonary
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