Q112. Approximately how much of the filtered urate is reabsorbed in the proximal tubule via URAT1?
Anonymous Quiz
6%
A) 10%
39%
B) 50%
55%
C) 90%
❤1👎1
Q113. Which condition increases urate retention in the kidneys?
Anonymous Quiz
23%
A) Respiratory alkalosis
51%
B) Lactic acidosis
26%
C) High GFR
❤3👎1
Q114. Hypouricemia (low uric acid) can be caused by:
Anonymous Quiz
1%
A) Obesity
96%
B) Xanthinuria (xanthine oxidase deficiency)
2%
C) Gout
❤🔥1
Q115. A common complication of chronic hyperuricemia is:
Anonymous Quiz
19%
A) Liver cirrhosis
69%
B) Kidney stones
12%
C) Osteoporosis
❤🔥1
Q116. Each gram of Hemoglobin (Hb) contains how much iron?
Anonymous Quiz
5%
A) 1 mg
90%
B) 3.4 mg
5%
C) 10 mg
❤🔥1❤1
Q117. Heme is chemically defined as a:
Anonymous Quiz
25%
A) Magnesium protoporphyrin
67%
B) Ferroprotoporphyrin
9%
C) Globulin chain
Q118. In Step 1 of heme synthesis, ALA synthase requires which cofactor?
Anonymous Quiz
3%
A) Vitamin B12
96%
B) Pyridoxal phosphate (B_6)
1%
C) Vitamin C
❤3🍓1
Q119. ALA dehydratase, which forms PBG, is inhibited by which toxic metal?
Anonymous Quiz
8%
A) Mercury
74%
B) Lead
18%
C) Aluminium
❤5👎1
Q120. PBG-deaminase is the enzyme responsible for converting PBG into:
Anonymous Quiz
12%
A) ALA
9%
B) Heme
78%
C) Uroporphyrinogen III
❤🔥1❤1
Q121. Uroporphyrinogen decarboxylase converts UPG-III into:
Anonymous Quiz
1%
A) Heme
4%
B) Protoporphyrin
95%
C) Coproporphyrinogen III (CPG-III)
❤3❤🔥1
Q122. The conversion of CPG-III to PPG-III occurs in the mitochondria and requires:
Anonymous Quiz
43%
A) CO_2
48%
B) O_2
9%
C) Na+
❤6👎1
Q123. Colored porphyrins are formed during which step?
Anonymous Quiz
1%
A) Step 1
8%
B) Step 2
91%
C) Step 6 (PPG-III to PP-III)
❤5❤🔥1
Q124. The final step of heme formation (PP-III + Fe2+) is catalyzed by:
Anonymous Quiz
3%
A) ALA synthase
72%
B) Ferrochelatase
26%
C) Carbonic anhydrase
❤4👎1
Q125. Most porphyrias are inherited in which pattern?
Anonymous Quiz
14%
A) Autosomal recessive
79%
B) Autosomal dominant
7%
C) X-linked
❤9👎1
Q126. Porphyrias are primarily classified into:
Anonymous Quiz
4%
A) Cardiac and Renal
93%
B) Hepatic and Erythropoietic
4%
C) Intestinal and Pulmonary
❤7❤🔥1
Q127. Which of the following is characteristic of Acute Intermittent Porphyria (AIP)?
Anonymous Quiz
3%
A) Severe photosensitivity
94%
B) Abdominal pain and neurological symptoms
3%
C) Low urine ALA
❤2🎉1💋1
Q128. The most common porphyria, which presents with photosensitivity, is:
Anonymous Quiz
36%
A) Acute Intermittent Porphyria
51%
B) Porphyria Cutanea Tarda
14%
C) Hereditary Coproporphyria
❤1👎1
Q129. Hereditary Coproporphyria is caused by a defect in which enzyme?
Anonymous Quiz
2%
A) Ferrochelatase
97%
B) Coproporphyrinogen oxidase
1%
C) ALA synthase
❤6🎉1🍓1
Q130. Erythropoietic Protoporphyria involves a defect in Ferrochelatase and results in:
Anonymous Quiz
1%
A) High urea
68%
B) Fluorescence in RBCs
31%
C) Absence of photosensitivity
❤3👎1
Q131. The total body iron in an adult is approximately:
Anonymous Quiz
1%
A) 1 g
96%
B) 4 g (70 mmol)
3%
C) 10 g
❤5🎉2
Q132. What percentage of dietary iron is typically absorbed?
Anonymous Quiz
3%
A) 1%
93%
B) 5-10%
5%
C) 50%
❤4🎉2