Let's Talk Medicine
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Causes of Rhabdomyolysis:
β€’ Traumatic, direct injury.
β€’ Non-traumatic exertional.
β€’ Non-traumatic non-exertional.

Check this out for more!
Rhabdomyolysis
πŸ”—: http://bit.ly/2rR0Cyo
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Gout: Inflammatory monarticular arthritis, caused by the precipitation of monosodium urate crystal into tissue, usually in and around joints.

Prevalence differs regionally❗️
i.e. rare in African Americans and very common in
Asians.
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Arthrocentesis is a definitive diagnosis test for Gout❗️

Gout vs. Psueodogout:
β€’ Hallmark of gout needle-shaped crystals with negative birefringent crystals.
β€’ Pseudogout has rhomboid shaped needles and slightly positive birefringence.
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Osteoarthritis is a degenerative joint disease that results from breakdown of joint cartilage and underlying bone.

β€’ The most common form of arthritis, often affects joints of the hands, knees, hips and spine.
β€’ The pain and stiffness may become severe enough to affect daily activities.
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Hashimoto's Thyroiditis: A condition in which altered T-cell-mediated immunity causes destruction of thyroid tissue and impaired gland function.

β€’ Also called: Chronic Lymphatic Thyroiditis.
β€’ The condition is characterized by a lymphocytic infiltrate and fibrosis.
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Hyperthyroidism: An increase in the circulating thyroid hormones (T3 & T4) due to an increase in its synthesis with a decrease in TSH levels.

Types:
β€’ Primary, caused by conditions related to the thyroid gland.
β€’ Secondary, caused by extra-thyroidal conditions like pituitary gland.
πŸ”΄ Thyroid hormones key points
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GIT functional motility:
β€’ Peristaltic or propulsive.
β€’ Segmentation or mixing.
β€’ Storage.

Check this out for more!
GIT Physiology
πŸ“Ή: http://bit.ly/2ofnBBe
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Appendicitis: Inflammation of the appendix.

Epidemiology:
β€’ It is the most common cause of acute abdomen requiring surgery.
β€’ The peak incidence for appendicitis is 10-30 years old.
β€’ Mortality rate is 0.1% in non-perforated cases.
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Obturator sign:
Passive internal rotation of the thigh will elicit pain in the RLQ.

Usually seen in pelvic appendicitis❗️
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Paralytic ileus/Adynamic bowel: Failure to move the luminal contents due to poor motility.

Simple bowel obstruction: Blockage of the bowel lumen at one area without complications (perforation, strangulation etc.).
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Causes of peptic ulcer disease:
β€’ Smoking.
β€’ NSAIDs.
β€’ H. pylori.
β€’ Other.
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Nephritic syndrome is a manifestation of glomerular inflammation, glomerulonephritis [GN], due to many causes leading to leakage of the larger cells (red blood cells – plasma proteins) through the filtration barrier.
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Classic features of nephritic syndrome:
β€’ Hematuria.
β€’ Edema.
β€’ Hypertension.
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P-THORAX summaries the presentation of pneumothorax:

Pleuritic chest pain.
Tracheal deviation.
Hyper-resonance on percussion.
Onset is sudden.
Reduced breath sounds unilaterally.
Absent fremitus.
X-ray shows lung collapse.
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Pulmonary Embolism: It is basically a blood clot that forms in the venous system traveling to the lung causing obstruction of the pulmonary vasculature.

β€’ It is suggested by the presence of acute onset of dyspnea, pleuritic chest pain, hypoxia, hemoptysis, low-grade fever, and tachycardia.
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Consider thrombolytic therapy as a treatment for a PE patient only if the patient is hemodynamically unstable (low SBP<90mmHg), and in cases of acute right ventricular dysfunction.
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Sources of [H+]:
β€’ Carbonic acid formation: the major source of H+ is from metabolically produced CO2.
β€’ Inorganic acid produced during nutrient breakdown: dietary proteins contain a large quantity of sulfuric acid and phosphoric acid.
β€’ Organic acid resulting from intermediary metabolism: lactic acid and fatty acids.
πŸ”΄ Chronic Hepatitis B
PPD test for Tuberculosis:
β€’ β‰₯5mm induration in high risk group ➑️HIV, and close contact.
β€’ β‰₯10mm induration in moderate risk group ➑️medical comorbidities, healthcare workers, and immigrants within the past 5 years.
β€’ β‰₯15mm induration in low risk group ➑️normal healthy individuals.