MCQ NO 831 | Pharmacology
Diffusion of drugs across cell membrane:
Diffusion of drugs across cell membrane:
Anonymous Quiz
22%
A. Is dependent upon metabolic activity of the cell
24%
B. Is competitively inhibited by chemically related drugs
46%
C. Is affected by extent of ionization of drug molecules
7%
D. Exhibits saturation kinetics
MCQ NO 832 | Pharmacology
Which of the following is not true of the blood-brain barrier:
Which of the following is not true of the blood-brain barrier:
Anonymous Quiz
27%
A. It is constituted by tight junctions between endothelial cells of brain capillaries &glial tissue
21%
B. It allows passage of lipid soluble drugs into the brain
26%
C. It limits entry of highly ionized drugs into the brain
26%
D. It regulates passage of substances from brain into blood
MCQ NO 833 | Pharmacology
Which of the following drugs exhibits ‘therapeutic window’ phenomenon:
Which of the following drugs exhibits ‘therapeutic window’ phenomenon:
Anonymous Quiz
18%
A. Captopril
28%
B. Furosemide
36%
C. Diazepam
19%
D. Imipramine
MCQ NO 834 | Pharmacology
The following statement is not true of ‘potency’ of a drug:
The following statement is not true of ‘potency’ of a drug:
Anonymous Quiz
24%
A. Refers to the dose of the drug needed to produce a certain degree of response
35%
B. Can be related to that of its congeners by relative position of dose-response curve on dose axis
28%
C. It is often not a major consideration in the choice of a drug
13%
D. It reflects the capacity of the drug to produce a drastic response
MCQ NO 835 | Pharmacology
Tetrodotoxin blocks nerve impulse/junctional trans- mission by:
Tetrodotoxin blocks nerve impulse/junctional trans- mission by:
Anonymous Quiz
17%
A. Anticholinergic action
34%
B. Depleting acetylcholine
39%
C. Blocking Na+ channels
10%
D. Blocking Ca2+ channels
MCQ NO 836 | Pharmacology
Betaxolol differs from timolol in that it:
Betaxolol differs from timolol in that it:
Anonymous Quiz
33%
A. Is a β1 selective blocker
30%
B. Is more efficacious in glaucoma
25%
C. Produces less ocular side effects
11%
D. Is longer acting
MCQ NO 837 | Pharmacology
Atropine does not antagonise the following feature of anticholinesterase poisoning:
Atropine does not antagonise the following feature of anticholinesterase poisoning:
Anonymous Quiz
20%
A. Hypotension
29%
B. Central excitation
28%
C. Muscle paralysis
23%
D. Bronchoconstriction
MCQ NO 838| Pharmacology
Amphetamine potentiates the following class of drugs:
Amphetamine potentiates the following class of drugs:
Anonymous Quiz
13%
A. Diuretics
22%
B. Analgesics
47%
C. Neuroleptics
18%
D. Antihypertensives
MCQ NO 839 | Pharmacology
Dexamphetamine produces an apparently paradoxical effect in:
Dexamphetamine produces an apparently paradoxical effect in:
Anonymous Quiz
10%
A. Addicts
37%
B. Athletes
43%
C. Parkinsonian patients
11%
D . Hyperkinetic children
MCQ NO 840 | Pharmacology
Labetalol differs from propranolol in that:
Labetalol differs from propranolol in that:
Anonymous Quiz
29%
A. It has additional α1 blocking property
23%
B. It is a selective β1 blocker
15%
C. It does not undergo first pass metabolism
33%
D. All of the above
MCQ NO 841 | Pharmacology
Anticancer drugs weaken host defence by:
Anticancer drugs weaken host defence by:
Anonymous Quiz
11%
A. Damaging respiratory and gut epithelia
16%
B. Inducing granulocytopenia
15%
C. Altering resident microbial flora
57%
D. Both 'A' and 'B' are correct
MCQ NO 842 | Pharmacology
Practically all antineoplastic drugs can produce the following toxic effects except:
Practically all antineoplastic drugs can produce the following toxic effects except:
Anonymous Quiz
25%
A. Depression of leucocyte count
21%
B. Mucositis
26%
C. Cardiomyopathy
27%
D. Oligozoospermia
MCQ NO 843 | Pharmacology
Alkylating agents exert cytotoxic action by inducing:
Alkylating agents exert cytotoxic action by inducing:
Anonymous Quiz
9%
A. Breakage of DNA strand
21%
B. Cross linking of DNA strands
21%
C. Abnormal pairing of purine and pyrimidine bases
49%
D. All of the above
MCQ NO 844| Pharmacology
The following is true of cyclophosphamide except:
The following is true of cyclophosphamide except:
Anonymous Quiz
25%
A. It is highly reactive and a vesicant on contact
29%
B. It is a prodrug
31%
C. It has marked immunosuppressant property
15%
D. It frequently causes alopecia and cystitis
MCQ NO 845| Pharmacology
The most important target of action of chlorambucil is:
The most important target of action of chlorambucil is:
Anonymous Quiz
30%
A. Myeloid tissue
47%
B. Lymphoid tissue
13%
C. Neural tissue
10%
D. Skin
MCQ NO 846 | Pharmacology
Methotrexate has the following attributes except:
Methotrexate has the following attributes except:
Anonymous Quiz
17%
A. It is cell cycle specific and kills cells in the S phase
35%
B. Its toxicity primarily affects bone marrow and epithelial structures
30%
C. Folic acid reverses its toxic effects
17%
D. It is the drug of choice for choriocarcinoma
MCQ NO 847 | Pharmacology
The following antineoplastic drug is a mitotic inhibitor and causes metaphase arrest:
The following antineoplastic drug is a mitotic inhibitor and causes metaphase arrest:
Anonymous Quiz
16%
A. Busulfan
56%
B. Vincristine
19%
C. Cytarabine
10%
D. Procarbazine
MCQ NO 848 | Pharmacology
Vinca alkaloids exert antitumor activity by:
Vinca alkaloids exert antitumor activity by:
Anonymous Quiz
18%
A. Activating topoisomerase II to cause breaks in DNA strands
12%
B. Crosslinking DNA strands
17%
C. Inhibiting DNA mediated RNA synthesis
53%
D. Inhibiting polymerization of tubulin to form intracellular microtubules
MCQ NO 849 | Pharmacology
The following cytotoxic drug acts by inhibiting depolymerization of tubulin and thus producing abnormal arrays of microtubules:
The following cytotoxic drug acts by inhibiting depolymerization of tubulin and thus producing abnormal arrays of microtubules:
Anonymous Quiz
25%
A. Paclitaxel
52%
B. Vinblastine
15%
C. Etoposide
8%
D. Mitoxantrone