HYPER-REACTIVITY:

Increase intensity of effect of a given dose of a drug in
comparison to effect seen in most individuals.

Hypersensitivity

Allergic or other immunological response to a drug.

Clinical manifestations
• Skin Reaction
– Urticaria
– Rashes
– Angioneurotic edema

• Blood Dyscrasias
– Thrombocytopenia
– Granulocytopenia
– Aplastic anemia
– Hemolysis
– Anaphylaxis, asthma, serum
sickness, hepatitis, nephropathy

"GENERAL CHEMICAL TESTS FOR ALKALOIDS"

Alkaloids are tested by the following reagents. Each reagent or test has accuracy and specificity.

1. Dragendroff's reagent
👉 This reagent is constituted of Potassium Bismuth lodide (PBI). Alkaloids give reddish brown color with the dragendroff's reagent.

2. Mayer's reagent:-
👉 This reagent is constituted of Potassium Mercuric lodide (PMI). Alkaloids give cream color with the Mayer's reagent. Remember M for Mayer M for Mercuric.

3. Wagner's reagent:-
👉 This reagent is constituted of lodine potassium lodide (IP). Alkaloids give reddish brown precipitate with the Wagner's reagent.

4.Hager's reagent :-
👉This reagent is constitutes of Picric Acid. Alkaloids give yellow precipitate with the Hager's reagent.

5. Tannic acid :-
👉With tannic acid alkaloids give buff colored precipitate.

6. Picrolinic acid :-
👉Yellow colored precipitate are produced with picrolinic acid.