MCQ NO 955 | Biochemistry
Hypercholremia is associated with.......
Hypercholremia is associated with.......
Anonymous Quiz
16%
Hyponatremia
24%
Hypernatremia
42%
Metabolic alkalosis
18%
Respiratory acidosis
🔴 Mechanism of Action 🔴
🔺Androgens & related drugs :-
Androgens ( Male sex Hormones)
Androgen ( Testosterone) binds with cytoplasmic androgen receptor (AR).... Form complex... Move into nucleus... Bind with androgen response elements of target gene.... Transcription.... Translation... Then effects are expressed through modification of protein synthesis.
🔺Actions:-
1.Sex organs and secondary sex characters development in boy at puberty.
2. Testosterone needed for nirmal spermatogenesis.
3.Anabolic effect on skeleton and skeletal muscles.
4.Erythropoiesis.
🔺 Anabolic steroids have similar actions like testosterone by bind with same receptor. E.g. Nandrolone, Oxymetholone, stanozolol, Methandienone ,etc.
🔺Androgens & related drugs :-
Androgens ( Male sex Hormones)
Androgen ( Testosterone) binds with cytoplasmic androgen receptor (AR).... Form complex... Move into nucleus... Bind with androgen response elements of target gene.... Transcription.... Translation... Then effects are expressed through modification of protein synthesis.
🔺Actions:-
1.Sex organs and secondary sex characters development in boy at puberty.
2. Testosterone needed for nirmal spermatogenesis.
3.Anabolic effect on skeleton and skeletal muscles.
4.Erythropoiesis.
🔺 Anabolic steroids have similar actions like testosterone by bind with same receptor. E.g. Nandrolone, Oxymetholone, stanozolol, Methandienone ,etc.
🔴ADRS OF ANDROGEN🔴
✔️virilization in women
✔️Acne in both male n female
✔️Oligozoospermia
✔️Precocious puberty
✔️Salt retension and edema
✔️Cholestatic jaundice
✔️Hepatic carcinoma
✔️Gynacosmastia
✔️virilization in women
✔️Acne in both male n female
✔️Oligozoospermia
✔️Precocious puberty
✔️Salt retension and edema
✔️Cholestatic jaundice
✔️Hepatic carcinoma
✔️Gynacosmastia
MCQ NO 956 | Pharmaceutical Engineering
The operational speed of propeller in mixing is..
The operational speed of propeller in mixing is..
Anonymous Quiz
32%
1000 RPM
38%
8000 RPM
27%
200 RPM
4%
50 RPM
MCQ NO 957 | Pharmaceutical Engineering
Which of the following is mechanism of mixing
Which of the following is mechanism of mixing
Anonymous Quiz
12%
Bulk transport
15%
Turbulent flow
6%
Laminar flow
67%
All of the above
MCQ NO 958 | Pharmaceutics
Tricafos is Proprietary name of _______
Tricafos is Proprietary name of _______
Anonymous Quiz
14%
Calcium Phosphate dibasic
69%
Calcium Phosphate tribasic
13%
Calcium sulphate
5%
Calcium carbonate
MCQ NO 959 | Pharmaceutics
The % concentration of Gelatin used as binder is ___
The % concentration of Gelatin used as binder is ___
Anonymous Quiz
21%
1-3
48%
5-20
22%
1-10
9%
Up to 50
MCQ NO 960 | Pharmacology
Following Drugs are metabolized by CYP2B6 isoenzyme EXCEPT .
Following Drugs are metabolized by CYP2B6 isoenzyme EXCEPT .
Anonymous Quiz
27%
Clopidogrel
27%
Sertraline
23%
Methadone
22%
Halothane
MCQ NO 961 | Pharmacology
The following substances are considered to be referred to as eicosanoids:
The following substances are considered to be referred to as eicosanoids:
Anonymous Quiz
10%
a) Prostaglandins
12%
b) Leukotrienes
14%
c) Thromboxanes
64%
d) All of the above
MCQ NO 962 | Pharmacology
Correct statements about cortisol (hydrocortisone) include all of the following, EXCEPT:
Correct statements about cortisol (hydrocortisone) include all of the following, EXCEPT:
Anonymous Quiz
16%
a) Cortisol is synthesized from cholesterol
20%
b) ACTH governs cortisol secretion
29%
c) Most cortisol is inactivated in the liver
35%
d) The half-life of cortisol in the circulations is normally about 60-90 hours
MCQ NO 963 | Pharmacology
Ranitidine is a___________
Ranitidine is a___________
Anonymous Quiz
59%
a) Proton pump inhibitor
14%
b) Reuptake pump inhibitor
11%
c)Amine pump inhibitor
16%
d)None of above
MCQ NO 964 | Pharmacology
Which of histamine H1 antagonists in noted for the serotonin-blocking effect?
Which of histamine H1 antagonists in noted for the serotonin-blocking effect?
Anonymous Quiz
28%
a. Brompheniramine
51%
b. Cyproheptadine
13%
c. Suprastine
8%
d. Dimedrol
MCQ NO 965 | Pharmacology
All of the following conditions are causes of hypothyroidism except
All of the following conditions are causes of hypothyroidism except
Anonymous Quiz
12%
a) Endemic goiter
39%
b) Surgical excision
32%
c) Graves’s disease
18%
d) goitrin-induced iodine deficiency
MCQ NO 966 | Pharmacology
Non-narcotic analgesics are mainly effective against pain associated with:
Non-narcotic analgesics are mainly effective against pain associated with:
Anonymous Quiz
12%
Trauma
19%
Myocardial infraction
54%
Inflammation or tissue damage
14%
Surgery
MCQ NO 967 | Pharmacology
Non-narcotic agents cause.........
Non-narcotic agents cause.........
Anonymous Quiz
23%
Respiratory depression
21%
Euphoria
19%
Physical dependence
37%
Antipyretic effect
MCQ NO 968 | pharmacology
Which of the following non-narcotic agents is salicylic acid derivative?
Which of the following non-narcotic agents is salicylic acid derivative?
Anonymous Quiz
10%
Phenylbutazone
16%
Ketamine
70%
Aspirin
4%
Tramadol
MCQ NO 969 | Pharmacology
Non-narcotic analgesics are all of the following drugs EXCEPT:
Non-narcotic analgesics are all of the following drugs EXCEPT:
Anonymous Quiz
17%
Paracetamol
21%
Acetylsalicylic acid
46%
Butorphanol
17%
Ketorolac
MCQ NO 970 | Pharmacology
Which one of the following non-narcotic agents inhibits mainly cyclooxygenase (COX) in CNS?
Which one of the following non-narcotic agents inhibits mainly cyclooxygenase (COX) in CNS?
Anonymous Quiz
21%
Ketorolac
37%
Acetylsalicylic acid
29%
Ibuprofen
14%
Paracetamol
🔴 Mechanism of Action 🔴
🔺1. Antiandrogens :-
a. Flutamide :- Non-steroidal AR (androgen receptor)antagonist with no other hormonal activity.
They are now used in conjunction with GnRH agonist or after castration to block the residual action of adrenal androgens as COMBINED ANDROGEN BLOCKED (CAB) therapy of metastatic carcinoma prostate.
b. Bicalutamide :- more potent and linger acting (half life is 6 days) congener of flutamide.
🔺2. 5-alpha reductase inhibitors
(e.g. Finasteride and Dutasteride)
These drugs are competitive inhibitor of 5 aloha reductase enzyme which converts the Testosterone intomore active Dyhydrotestosterone and gives androgenic action in many tissues.... So, these drugs reduce this effect by blocking the 5-alpha reductase enzyme.
🔺Note...
Finasteride selectively inhibit type 2 isoenzyme 5-alpha reductase.
Dutasteride inhibit both type 1 and type 2 isoenzymes (5-alpha reductase) and inhibit DHT levels.
🔺1. Antiandrogens :-
a. Flutamide :- Non-steroidal AR (androgen receptor)antagonist with no other hormonal activity.
They are now used in conjunction with GnRH agonist or after castration to block the residual action of adrenal androgens as COMBINED ANDROGEN BLOCKED (CAB) therapy of metastatic carcinoma prostate.
b. Bicalutamide :- more potent and linger acting (half life is 6 days) congener of flutamide.
🔺2. 5-alpha reductase inhibitors
(e.g. Finasteride and Dutasteride)
These drugs are competitive inhibitor of 5 aloha reductase enzyme which converts the Testosterone intomore active Dyhydrotestosterone and gives androgenic action in many tissues.... So, these drugs reduce this effect by blocking the 5-alpha reductase enzyme.
🔺Note...
Finasteride selectively inhibit type 2 isoenzyme 5-alpha reductase.
Dutasteride inhibit both type 1 and type 2 isoenzymes (5-alpha reductase) and inhibit DHT levels.
🔴ADRS OF ANTIANDROGENS🔴
✔️Androgenic anabolism is suppressed
✔️Gynacosmastia
✔️Breast tenderness
✔️Liver damage occures frequently
✔️Skin rashes
✔️Swelling of lips
✔️Androgenic anabolism is suppressed
✔️Gynacosmastia
✔️Breast tenderness
✔️Liver damage occures frequently
✔️Skin rashes
✔️Swelling of lips
MCQ NO 971 | Pharmaceutical jurisprudence
Licence to manufacture for sale Homoeopathic Medicine specified in
Licence to manufacture for sale Homoeopathic Medicine specified in
Anonymous Quiz
23%
A. 25A
31%
B. 25D
24%
C. 25E
22%
D. 21A