Which of the following best represents Total Iron Binding Capacity (TIBC)?
Anonymous Quiz
37%
A) The amount of iron bound to transferrin
20%
B) The total iron stored in ferritin
37%
C) The total number of available binding sites on transferrin
7%
D) The amount of iron
Ferritin is a marker of:
Anonymous Quiz
9%
A) Circulating iron in the blood
14%
B) Iron bound to transferrin
66%
C) Total body iron stores
11%
D) Iron absorption in the gut
In iron deficiency anemia, what happens to TIBC?
Anonymous Quiz
24%
A) Decreases
56%
B) Increases
7%
C) Remains normal
13%
D) First increases, then decreases
Which condition would NOT typically cause iron deficiency anemia?
Anonymous Quiz
22%
A) Chronic blood loss (e.g., menorrhagia)
22%
B) Malabsorption (e.g., celiac disease)
21%
C) Increased hepcidin due to inflammation
35%
D) Excessive red meat consumption
A patient with low serum iron, low TIBC, and high ferritin likely has:
Anonymous Quiz
22%
A) Iron deficiency anemia
42%
B) Anemia of chronic disease
21%
C) Hemochromatosis
15%
D) Lead poisoning
Which finding is not typical of iron deficiency anemia?
Anonymous Quiz
24%
A) Koilonychia (spoon-shaped nails)
44%
B) High reticulocyte count
17%
C) Pica (craving ice/dirt)
15%
D) Fatigue
What is the first lab test to become abnormal in early iron deficiency?
Anonymous Quiz
34%
A) Hemoglobin
31%
B) Ferritin
16%
C) MCV
19%
D) Serum iron
👍1
In which condition is hepcidin low?
Anonymous Quiz
10%
A) ACD
56%
B) Hereditary Hemochromatosis
18%
C) IRIDA
16%
D) IDA
What is the expected MCV in untreated hereditary hemochromatosis?
Anonymous Quiz
30%
A) Normal (80–100 fL)
38%
B) Low (<80 fL)
19%
C) High (>100 fL)
12%
D) Variable
Which test reliably distinguishes ACD from IDA in a patient with chronic inflammation?
Anonymous Quiz
13%
A) Serum Iron
44%
B) Soluble Transferrin Receptor (sTfR)
30%
C) TIBC
13%
D) MCV
A 30-year-old woman with heavy menstrual bleeding has fatigue, pallor, and ice cravings. Labs: Hb 9.0 g/dL (↓), MCV 72 fL (↓), serum iron 30 mcg/dL (↓), TIBC 480 mcg/dL (↑), ferritin 8 ng/mL (↓).
Question: What is the most likely diagnosis?
Question: What is the most likely diagnosis?
Anonymous Quiz
16%
A) Anemia of chronic disease
71%
B) Iron deficiency anemia
6%
C) Thalassemia
6%
D) Hemochromatosis
A 60-year-old man with rheumatoid arthritis and elevated CRP has Hb 10.5 g/dL (↓), MCV 85 fL, serum iron 40 mcg/dL (↓), TIBC 250 mcg/dL (↓), ferritin 350 ng/mL (↑).
Question: Why is TIBC low?
Question: Why is TIBC low?
Anonymous Quiz
19%
A) Iron overload
60%
B) Chronic inflammation
13%
C) Hemolysis
8%
D) Vitamin B12 deficiency
👍1
A 45-year-old with Crohn’s disease and GI bleeding has Hb 8.5 g/dL (↓), MCV 78 fL (↓), serum iron 25 mcg/dL (↓), TIBC 400 mcg/dL (↑), ferritin 120 ng/mL (↑), CRP 50 mg/L (↑).
Question: Which test confirms iron deficiency?
Question: Which test confirms iron deficiency?
Anonymous Quiz
18%
A) Serum iron
53%
B) Soluble transferrin receptor (sTfR)
21%
C) TIBC
9%
D) CRP
A 12-year-old boy with lifelong microcytic anemia unresponsive to oral iron has Hb 8.8 g/dL (↓), MCV 68 fL (↓), serum iron 20 mcg/dL (↓), TIBC 500 mcg/dL (↑), ferritin 15 ng/m
Anonymous Quiz
25%
A)IDA
31%
B)ACD
26%
C)IRIDA
18%
D)Hemochromatosis
A child with microcytic anemia unresponsive to oral iron has serum iron 25 mcg/dL (↓), TIBC 480 mcg/dL (↑), ferritin 20 ng/mL (↓), ↑ hepcidin.
Question: Why is oral iron ineffective?
Question: Why is oral iron ineffective?
Anonymous Quiz
17%
A) Gut malabsorption
56%
B) Hepcidin excess
24%
C) Vitamin C deficiency
3%
D) Hemolysis
A 10-year-old child with lifelong microcytic anemia unresponsive to oral iron has:
Serum Iron: 18 µg/dL (Low) TIBC: 450 µg/dL (Normal) TSAT: 4% (Very Low) Ferritin: 50 µg/L (Normal) MCV: 68 fL (Low) Question: What disorder is suspected?
Serum Iron: 18 µg/dL (Low) TIBC: 450 µg/dL (Normal) TSAT: 4% (Very Low) Ferritin: 50 µg/L (Normal) MCV: 68 fL (Low) Question: What disorder is suspected?
Anonymous Quiz
12%
A) ACD
40%
B) IRIDA
33%
C) Thalassemia
15%
D) Hemochromatosis
❤1
Case: A 30-year-old woman with menorrhagia has fatigue and pallor. Labs:
Hb: 8.8 g/dL (↓) MCV: 70 fL (↓) Serum Iron: 20 µg/dL (↓) TIBC: 500 µg/dL (↑) Ferritin: 12 µg/L (↓) Question: Which parameter confirms IDA?
Hb: 8.8 g/dL (↓) MCV: 70 fL (↓) Serum Iron: 20 µg/dL (↓) TIBC: 500 µg/dL (↑) Ferritin: 12 µg/L (↓) Question: Which parameter confirms IDA?
Anonymous Quiz
29%
A) High TIBC
51%
B) Low Ferritin
17%
C) Elevated CRP
3%
D) Normal MCV
Which lab pattern is typical of IRIDA?
Anonymous Quiz
38%
A) ↓ Serum Iron, ↑ TIBC, ↓ Ferritin
35%
B) ↓ Serum Iron, Normal TIBC, Normal Ferritin
13%
C) ↑ Serum Iron, ↓ TIBC, ↑ Ferritin
14%
D) ↓ Serum Iron, ↓ TIBC, ↑ Ferritin
Case: A patient with IRIDA has:
MCV: 65 fL (↓) Ferritin: 60 µg/L (normal) TSAT: 5% (↓↓) Question: Why is the MCV low?
MCV: 65 fL (↓) Ferritin: 60 µg/L (normal) TSAT: 5% (↓↓) Question: Why is the MCV low?
Anonymous Quiz
19%
A) Vitamin B12 deficiency
68%
B) Microcytic anemia due to iron deficiency
7%
C) Hemolysis
5%
D) Chronic inflammation
Question: Which condition is associated with low TIBC?
Anonymous Quiz
26%
A) IDA
27%
B) ACD
14%
C) IRIDA
33%
D) Thalassemia
👍2
What does a low ACTH level with high cortisol indicate in the ACTH test?
Anonymous Quiz
20%
A) Pituitary problem
16%
B) Addison’s disease
56%
C) Adrenal problem (ACTH-independent)
7%
D) CRH overproduction