Transferrin saturation (TSAT) is calculated by which formula?
Anonymous Quiz
43%
A) (Serum Iron / TIBC) × 100
26%
B) (TIBC / Serum Iron) × 100
21%
C) (Ferritin / Serum Iron) × 100
10%
D) (Serum Iron / Ferritin) × 100
A patient has the following lab results:
Low serum iron
High TIBC Low transferrin saturation Low ferritin What is the most likely diagnosis?
Low serum iron
High TIBC Low transferrin saturation Low ferritin What is the most likely diagnosis?
Anonymous Quiz
16%
A) Anemia of chronic disease
65%
B) Iron deficiency anemia
10%
C) Hemolytic anemia
9%
D) Thalassemia
👍2
Which of the following best represents Total Iron Binding Capacity (TIBC)?
Anonymous Quiz
37%
A) The amount of iron bound to transferrin
20%
B) The total iron stored in ferritin
37%
C) The total number of available binding sites on transferrin
7%
D) The amount of iron
Ferritin is a marker of:
Anonymous Quiz
9%
A) Circulating iron in the blood
14%
B) Iron bound to transferrin
66%
C) Total body iron stores
11%
D) Iron absorption in the gut
In iron deficiency anemia, what happens to TIBC?
Anonymous Quiz
24%
A) Decreases
56%
B) Increases
7%
C) Remains normal
13%
D) First increases, then decreases
Which condition would NOT typically cause iron deficiency anemia?
Anonymous Quiz
22%
A) Chronic blood loss (e.g., menorrhagia)
22%
B) Malabsorption (e.g., celiac disease)
21%
C) Increased hepcidin due to inflammation
35%
D) Excessive red meat consumption
A patient with low serum iron, low TIBC, and high ferritin likely has:
Anonymous Quiz
22%
A) Iron deficiency anemia
42%
B) Anemia of chronic disease
21%
C) Hemochromatosis
15%
D) Lead poisoning
Which finding is not typical of iron deficiency anemia?
Anonymous Quiz
24%
A) Koilonychia (spoon-shaped nails)
44%
B) High reticulocyte count
17%
C) Pica (craving ice/dirt)
15%
D) Fatigue
What is the first lab test to become abnormal in early iron deficiency?
Anonymous Quiz
34%
A) Hemoglobin
31%
B) Ferritin
16%
C) MCV
19%
D) Serum iron
👍1
In which condition is hepcidin low?
Anonymous Quiz
10%
A) ACD
56%
B) Hereditary Hemochromatosis
18%
C) IRIDA
16%
D) IDA
What is the expected MCV in untreated hereditary hemochromatosis?
Anonymous Quiz
30%
A) Normal (80–100 fL)
38%
B) Low (<80 fL)
19%
C) High (>100 fL)
12%
D) Variable
Which test reliably distinguishes ACD from IDA in a patient with chronic inflammation?
Anonymous Quiz
13%
A) Serum Iron
44%
B) Soluble Transferrin Receptor (sTfR)
30%
C) TIBC
13%
D) MCV
A 30-year-old woman with heavy menstrual bleeding has fatigue, pallor, and ice cravings. Labs: Hb 9.0 g/dL (↓), MCV 72 fL (↓), serum iron 30 mcg/dL (↓), TIBC 480 mcg/dL (↑), ferritin 8 ng/mL (↓).
Question: What is the most likely diagnosis?
Question: What is the most likely diagnosis?
Anonymous Quiz
16%
A) Anemia of chronic disease
71%
B) Iron deficiency anemia
6%
C) Thalassemia
6%
D) Hemochromatosis
A 60-year-old man with rheumatoid arthritis and elevated CRP has Hb 10.5 g/dL (↓), MCV 85 fL, serum iron 40 mcg/dL (↓), TIBC 250 mcg/dL (↓), ferritin 350 ng/mL (↑).
Question: Why is TIBC low?
Question: Why is TIBC low?
Anonymous Quiz
19%
A) Iron overload
60%
B) Chronic inflammation
13%
C) Hemolysis
8%
D) Vitamin B12 deficiency
👍1
A 45-year-old with Crohn’s disease and GI bleeding has Hb 8.5 g/dL (↓), MCV 78 fL (↓), serum iron 25 mcg/dL (↓), TIBC 400 mcg/dL (↑), ferritin 120 ng/mL (↑), CRP 50 mg/L (↑).
Question: Which test confirms iron deficiency?
Question: Which test confirms iron deficiency?
Anonymous Quiz
18%
A) Serum iron
53%
B) Soluble transferrin receptor (sTfR)
21%
C) TIBC
9%
D) CRP
A 12-year-old boy with lifelong microcytic anemia unresponsive to oral iron has Hb 8.8 g/dL (↓), MCV 68 fL (↓), serum iron 20 mcg/dL (↓), TIBC 500 mcg/dL (↑), ferritin 15 ng/m
Anonymous Quiz
25%
A)IDA
31%
B)ACD
26%
C)IRIDA
18%
D)Hemochromatosis
A child with microcytic anemia unresponsive to oral iron has serum iron 25 mcg/dL (↓), TIBC 480 mcg/dL (↑), ferritin 20 ng/mL (↓), ↑ hepcidin.
Question: Why is oral iron ineffective?
Question: Why is oral iron ineffective?
Anonymous Quiz
17%
A) Gut malabsorption
56%
B) Hepcidin excess
24%
C) Vitamin C deficiency
3%
D) Hemolysis
A 10-year-old child with lifelong microcytic anemia unresponsive to oral iron has:
Serum Iron: 18 µg/dL (Low) TIBC: 450 µg/dL (Normal) TSAT: 4% (Very Low) Ferritin: 50 µg/L (Normal) MCV: 68 fL (Low) Question: What disorder is suspected?
Serum Iron: 18 µg/dL (Low) TIBC: 450 µg/dL (Normal) TSAT: 4% (Very Low) Ferritin: 50 µg/L (Normal) MCV: 68 fL (Low) Question: What disorder is suspected?
Anonymous Quiz
12%
A) ACD
40%
B) IRIDA
33%
C) Thalassemia
15%
D) Hemochromatosis
❤1
Case: A 30-year-old woman with menorrhagia has fatigue and pallor. Labs:
Hb: 8.8 g/dL (↓) MCV: 70 fL (↓) Serum Iron: 20 µg/dL (↓) TIBC: 500 µg/dL (↑) Ferritin: 12 µg/L (↓) Question: Which parameter confirms IDA?
Hb: 8.8 g/dL (↓) MCV: 70 fL (↓) Serum Iron: 20 µg/dL (↓) TIBC: 500 µg/dL (↑) Ferritin: 12 µg/L (↓) Question: Which parameter confirms IDA?
Anonymous Quiz
29%
A) High TIBC
51%
B) Low Ferritin
17%
C) Elevated CRP
3%
D) Normal MCV
Which lab pattern is typical of IRIDA?
Anonymous Quiz
38%
A) ↓ Serum Iron, ↑ TIBC, ↓ Ferritin
35%
B) ↓ Serum Iron, Normal TIBC, Normal Ferritin
13%
C) ↑ Serum Iron, ↓ TIBC, ↑ Ferritin
14%
D) ↓ Serum Iron, ↓ TIBC, ↑ Ferritin
Case: A patient with IRIDA has:
MCV: 65 fL (↓) Ferritin: 60 µg/L (normal) TSAT: 5% (↓↓) Question: Why is the MCV low?
MCV: 65 fL (↓) Ferritin: 60 µg/L (normal) TSAT: 5% (↓↓) Question: Why is the MCV low?
Anonymous Quiz
19%
A) Vitamin B12 deficiency
68%
B) Microcytic anemia due to iron deficiency
7%
C) Hemolysis
5%
D) Chronic inflammation