Biosimilar Competition in Oncology—Beyond Insurer Pressure
https://jamanetwork.com/journals/jama/fullarticle/2846348
The high price of drugs continues to be the focus of policy discussions, with attention often drawn to the importance of promoting price competition through the use of generic and biosimilar versions of branded reference products. As occurred with small-molecule drugs and generics after the passage of the Hatch-Waxman Act of 1984, the creation of a biosimilar approval pathway in the Affordable Care Act’s Biologics Price Competition and Innovation Act was intended to lower spending on biologic products after reference-product patents expire.
https://jamanetwork.com/journals/jama/fullarticle/2846348
The high price of drugs continues to be the focus of policy discussions, with attention often drawn to the importance of promoting price competition through the use of generic and biosimilar versions of branded reference products. As occurred with small-molecule drugs and generics after the passage of the Hatch-Waxman Act of 1984, the creation of a biosimilar approval pathway in the Affordable Care Act’s Biologics Price Competition and Innovation Act was intended to lower spending on biologic products after reference-product patents expire.
Peanut Allergy
https://jamanetwork.com/journals/jama/fullarticle/2846347
This JAMA Insights discusses peanut allergy, including diagnosis, introduction of peanuts to infant diet, and immunotherapy options.
https://jamanetwork.com/journals/jama/fullarticle/2846347
This JAMA Insights discusses peanut allergy, including diagnosis, introduction of peanuts to infant diet, and immunotherapy options.
A Criticism of Modern Medicine
https://jamanetwork.com/journals/jama/fullarticle/2846423
A conscientious reviewer of the history of medicine would probably admit that within the last century, and largely within half that period, medical science and art have advanced with a speed incomparably greater than at any previous time. Philosophical speculation has given way to experimentation as medicine has kept pace with the advancement of science in general. It would be as ungracious as it is unjust to deny the great advance of medical knowledge along with the evolution of culture; and medicine can proudly boast of many conquests that deserve to be called marvelous.
https://jamanetwork.com/journals/jama/fullarticle/2846423
A conscientious reviewer of the history of medicine would probably admit that within the last century, and largely within half that period, medical science and art have advanced with a speed incomparably greater than at any previous time. Philosophical speculation has given way to experimentation as medicine has kept pace with the advancement of science in general. It would be as ungracious as it is unjust to deny the great advance of medical knowledge along with the evolution of culture; and medicine can proudly boast of many conquests that deserve to be called marvelous.
Psilocybin Trends in States That Decriminalized Use
https://jamanetwork.com/journals/jama/fullarticle/2846422
This survey study examines the estimated increase in 12-month psilocybin use in Oregon and Colorado associated with decriminalization.
https://jamanetwork.com/journals/jama/fullarticle/2846422
This survey study examines the estimated increase in 12-month psilocybin use in Oregon and Colorado associated with decriminalization.
An Interview With Dr Robert M. Wachter
https://jamanetwork.com/journals/jama/fullarticle/2846421
JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, spoke with Robert M. Wachter, MD, professor and chair of the Department of Medicine at University of California, San Francisco, for JAMA+ AI Conversations.
https://jamanetwork.com/journals/jama/fullarticle/2846421
JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, spoke with Robert M. Wachter, MD, professor and chair of the Department of Medicine at University of California, San Francisco, for JAMA+ AI Conversations.
Triple Negative
https://jamanetwork.com/journals/jama/fullarticle/2846420
In this essay, a hematologist and endurance athlete discovers an aggressive breast cancer, causing her to redefine endurance as embracing uncertainty and vulnerability while navigating life as both physician and patient.
https://jamanetwork.com/journals/jama/fullarticle/2846420
In this essay, a hematologist and endurance athlete discovers an aggressive breast cancer, causing her to redefine endurance as embracing uncertainty and vulnerability while navigating life as both physician and patient.
Audio Highlights March 13, 2026
https://jamanetwork.com/journals/jama/fullarticle/2846724
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
https://jamanetwork.com/journals/jama/fullarticle/2846724
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
CDC Reports Highlight Rise in Obesity During the 21st Century
https://jamanetwork.com/journals/jama/fullarticle/2846621
The US Centers for Disease Control and Prevention (CDC) reported that about 40% of US adults aged 20 years or older had obesity from August 2021 to 2023, including 10% with severe obesity.
https://jamanetwork.com/journals/jama/fullarticle/2846621
The US Centers for Disease Control and Prevention (CDC) reported that about 40% of US adults aged 20 years or older had obesity from August 2021 to 2023, including 10% with severe obesity.
FDA Approves New Device for Pancreatic Cancer Treatment
https://jamanetwork.com/journals/jama/fullarticle/2846620
The US Food and Drug Administration (FDA) recently approved a first-of-its-kind device to treat adult patients with locally advanced pancreatic cancer.
https://jamanetwork.com/journals/jama/fullarticle/2846620
The US Food and Drug Administration (FDA) recently approved a first-of-its-kind device to treat adult patients with locally advanced pancreatic cancer.
Pregnancy Biomarkers May Offer Insight Into Future CVD Risk
https://jamanetwork.com/journals/jama/fullarticle/2846619
Certain biomarkers measured during pregnancy may help predict long-term cardiovascular disease (CVD) risk, according to new research.
https://jamanetwork.com/journals/jama/fullarticle/2846619
Certain biomarkers measured during pregnancy may help predict long-term cardiovascular disease (CVD) risk, according to new research.
ORCHESTRA Hits a Sour Note for Debulking in Metastatic Colorectal Cancer
https://jamanetwork.com/journals/jama/fullarticle/2846538
Colorectal cancer (CRC) remains one of the few solid tumors for which surgical intervention to remove limited metastatic disease has been associated with curative outcomes or improved overall survival. This has been demonstrated in liver-limited, lung-limited, and peritoneal-limited disease. Encouraging findings from hepatectomy in liver-limited disease led to extrapolation of resection to patients with multiple organ involvement in whom complete resection could be attained. Indeed, resection in patients with liver and lung metastases has been linked to favorable survival, as has resection in patients with peritoneal metastases with limited liver involvement. Although most patients undergoing curative resections have metastases recur, their median overall survival has typically been favorable compared with historic controls.
https://jamanetwork.com/journals/jama/fullarticle/2846538
Colorectal cancer (CRC) remains one of the few solid tumors for which surgical intervention to remove limited metastatic disease has been associated with curative outcomes or improved overall survival. This has been demonstrated in liver-limited, lung-limited, and peritoneal-limited disease. Encouraging findings from hepatectomy in liver-limited disease led to extrapolation of resection to patients with multiple organ involvement in whom complete resection could be attained. Indeed, resection in patients with liver and lung metastases has been linked to favorable survival, as has resection in patients with peritoneal metastases with limited liver involvement. Although most patients undergoing curative resections have metastases recur, their median overall survival has typically been favorable compared with historic controls.
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Political Theater and the Great Healthcare Plan
https://jamanetwork.com/journals/jama/fullarticle/2846528
This Perspective examines various aspects of the Great Healthcare Plan related to drug pricing, including over-the-counter expansion; subsidies, rebates, and cost sharing; and price transparency.
https://jamanetwork.com/journals/jama/fullarticle/2846528
This Perspective examines various aspects of the Great Healthcare Plan related to drug pricing, including over-the-counter expansion; subsidies, rebates, and cost sharing; and price transparency.
Research Summary
https://jamanetwork.com/journals/jama/fullarticle/2846527
This randomized clinical trial evaluated whether adding tumor debulking to palliative chemotherapy improves overall survival for patients with multiorgan metastatic colorectal cancer.
https://jamanetwork.com/journals/jama/fullarticle/2846527
This randomized clinical trial evaluated whether adding tumor debulking to palliative chemotherapy improves overall survival for patients with multiorgan metastatic colorectal cancer.
Clarifying the SOFA-2 Score
https://jamanetwork.com/journals/jama/fullarticle/2846536
To the Editor The SOFA-2 score is an important step toward improving the precision of organ dysfunction assessment in contemporary critical care. By redefining thresholds within its 6 organ domains using data-driven modeling, SOFA-2 enhances calibration and predictive performance in sepsis cohorts. However, its direct application to tropical infections such as dengue, scrub typhus, leptospirosis, and malaria warrants cautious interpretation. The physiological foundations of SOFA-2 are largely derived from bacterial sepsis, and certain domains, particularly hepatic and coagulation, may not fully capture the pathophysiological profiles seen in these infections.
https://jamanetwork.com/journals/jama/fullarticle/2846536
To the Editor The SOFA-2 score is an important step toward improving the precision of organ dysfunction assessment in contemporary critical care. By redefining thresholds within its 6 organ domains using data-driven modeling, SOFA-2 enhances calibration and predictive performance in sepsis cohorts. However, its direct application to tropical infections such as dengue, scrub typhus, leptospirosis, and malaria warrants cautious interpretation. The physiological foundations of SOFA-2 are largely derived from bacterial sepsis, and certain domains, particularly hepatic and coagulation, may not fully capture the pathophysiological profiles seen in these infections.
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Clarifying the SOFA-2 Score
https://jamanetwork.com/journals/jama/fullarticle/2846535
To the Editor Dr Ranzani and colleagues describe the development and validation of the SOFA-2 score, a major update of an organ dysfunction index central to both clinical research and bedside assessment in critical care medicine.
https://jamanetwork.com/journals/jama/fullarticle/2846535
To the Editor Dr Ranzani and colleagues describe the development and validation of the SOFA-2 score, a major update of an organ dysfunction index central to both clinical research and bedside assessment in critical care medicine.
Clarifying the SOFA-2 Score
https://jamanetwork.com/journals/jama/fullarticle/2846534
To the Editor As members of the Executive Committee of the European Group on Immunology of Sepsis (EGIS), we are writing about the recent article describing the development and validation of the SOFA-2 score. The authors revised the original SOFA score by integrating modern intensive care unit (ICU) interventions such as renal replacement therapy and extracorporeal membrane oxygenation, resulting in an updated index reflecting contemporary ICU practice.
https://jamanetwork.com/journals/jama/fullarticle/2846534
To the Editor As members of the Executive Committee of the European Group on Immunology of Sepsis (EGIS), we are writing about the recent article describing the development and validation of the SOFA-2 score. The authors revised the original SOFA score by integrating modern intensive care unit (ICU) interventions such as renal replacement therapy and extracorporeal membrane oxygenation, resulting in an updated index reflecting contemporary ICU practice.
Clarifying the SOFA-2 Score—Reply
https://jamanetwork.com/journals/jama/fullarticle/2846532
In Reply We appreciate the interest in the updated SOFA score (SOFA-2). We reiterate herein that SOFA-2 is primarily a descriptive scale to quantify organ dysfunction and is not a predictive score. The area under the receiver operating curve mentioned by Mr Matos and colleagues is reported as a metric to demonstrate predictive validity, 1 of 6 utility domains prespecified in our protocol.
https://jamanetwork.com/journals/jama/fullarticle/2846532
In Reply We appreciate the interest in the updated SOFA score (SOFA-2). We reiterate herein that SOFA-2 is primarily a descriptive scale to quantify organ dysfunction and is not a predictive score. The area under the receiver operating curve mentioned by Mr Matos and colleagues is reported as a metric to demonstrate predictive validity, 1 of 6 utility domains prespecified in our protocol.
Error in Text
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846286
In the Invited Commentary titled “Reducing Early Stroke Recurrence Risk—Beyond Antithrombotics,” published online November 3, 2025, and in the January 2026 issue, there was an error in the text. In the second paragraph, the text was updated to “Neither statins nor early initiation of antihypertensive agents have shown early benefit for patients with acute ischemic stroke.” This article was corrected online.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846286
In the Invited Commentary titled “Reducing Early Stroke Recurrence Risk—Beyond Antithrombotics,” published online November 3, 2025, and in the January 2026 issue, there was an error in the text. In the second paragraph, the text was updated to “Neither statins nor early initiation of antihypertensive agents have shown early benefit for patients with acute ischemic stroke.” This article was corrected online.
JAMA Internal Medicine Peer Reviewers in 2025
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846276
We sincerely thank the 1127 peer reviewers who completed manuscript reviews for JAMA Internal Medicine in 2025.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846276
We sincerely thank the 1127 peer reviewers who completed manuscript reviews for JAMA Internal Medicine in 2025.
eConsult-Integrated Care to Improve Specialty Access
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846275
This Viewpoint discusses eConsult-integrated care to improve access to specialty health care.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846275
This Viewpoint discusses eConsult-integrated care to improve access to specialty health care.
Extended-Release Buprenorphine During Pregnancy and the First Year After Birth
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846284
Pregnant and parenting people are among the groups most negatively impacted by the opioid crisis, yet they are last in line for rigorous medication research to improve outcomes. Overdose continues to be a leading cause of maternal deaths in the United States, and substance use is the primary reason infants are separated from their parents.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846284
Pregnant and parenting people are among the groups most negatively impacted by the opioid crisis, yet they are last in line for rigorous medication research to improve outcomes. Overdose continues to be a leading cause of maternal deaths in the United States, and substance use is the primary reason infants are separated from their parents.