Infectious Disease / Microbiology Updates
6.65K subscribers
31 photos
3 videos
23 files
3.72K links
All the atest articles, research and news from worlds leading Infectious Disease Journals.

Discussion group
https://t.me/Professional_Medical_Discussion
Download Telegram
[Comment] Preventing tuberculosis in advanced HIV disease
https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(25)00277-2/fulltext?rss=yes

The persistent and high burden of advanced HIV disease in endemic settings is a major threat to global efforts to reduce AIDS-related hospitalisations and deaths. In 2024, over 600 000 people died from AIDS-related opportunistic infections, with over half of these deaths due to cryptococcal meningitis and tuberculosis. We now have innovative diagnostic, preventive, and therapeutic interventions to combat these diseases, but implementing these new tools among people with advanced HIV presents several enduring challenges.
1
[Articles] Inpatient initiation of tuberculosis preventive therapy with 1 month of isoniazid and rifapentine for adults with advanced HIV disease and cryptococcal meningitis (IMPROVE): a non-inferiority, randomised controlled trial
https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(25)00246-2/fulltext?rss=yes

1HP initiation before hospital discharge was non-inferior to outpatient initiation among adults with AHD and cryptococcosis. These data suggest that following exclusion of active tuberculosis disease, inpatient 1HP initiation is feasible and comparably safe compared with outpatient initiation.