Infectious Disease / Microbiology Updates
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[Newsdesk] Brazil approves domestic single-shot dengue vaccine
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00013-7/fulltext?rss=yes

In December 2025, the domestically produced Butantan-DV vaccine was approved by Brazil's regulatory agency for use in individuals aged 12–59 years. Marcia Triunfol reports.
[Comment] Lessons from Brazil's elimination of vertical HIV transmission
https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(26)00002-0/fulltext?rss=yes

In 2025, WHO's validation of Brazil for the elimination of vertical transmission of HIV (sometimes referred to as mother-to-child transmission of HIV) is a landmark global public health achievement.1 As the most populous country to reach this milestone, Brazil shows that elimination is feasible even in large, socially diverse, and unequal settings when political commitment, universal health coverage, and human rights are placed at the centre of health policy.1 This success highlights the urgency for countries in sub-Saharan Africa to implement concrete, scalable, and equity-oriented strategies to achieve similar progress in eliminating vertical transmission of HIV.
[Articles] Acceptability and tolerability of long-acting injectable cabotegravir–rilpivirine in adolescents with HIV-1 (IMPAACT 2017/MOCHA): 48-week results of a multicentre, open-label, non-comparative phase 1/2 trial
https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(25)00241-3/fulltext?rss=yes

Acceptability and tolerability of intramuscular cabotegravir–rilpivirine remained high through to 48 weeks of treatment, suggesting that this long-acting intramuscular treatment approach is well received by diverse populations of adolescents with HIV across multiple settings.
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[Articles] Safety, antiviral activity, and pharmacokinetics of long-acting injectable cabotegravir–rilpivirine in virologically suppressed adolescents living with HIV-1 (IMPAACT 2017/MOCHA): 48-week results of a multinational, phase 1/2, single-arm study
https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(25)00242-5/fulltext?rss=yes

Week 48 data from the first virologically suppressed adolescents with HIV-1 who switched from daily oral to intramuscular cabotegravir and intramuscular rilpivirine every 8 weeks showed favourable safety, pharmacokinetics, and virological suppression informing both real-world use, where approved, and ongoing regulatory submissions, where approval is pending.