MY MY MY AUTOPHAGY ...these screenshots are from the software I use to analyze my clients’ genes (enzymes.). They give me a visual of where variated genes may be contributing to inflammation and holding up detoxification.
You will see where NAD+, NMN, NADH, and its cousins, fit into the biochemistry of detoxification and autophagy (cellular cleanup). This is me. I have variants genes that make an enzyme called Nrf2 which signals release of glutathione and has a role, like B3, in autophagy.
You will see where NAD+, NMN, NADH, and its cousins, fit into the biochemistry of detoxification and autophagy (cellular cleanup). This is me. I have variants genes that make an enzyme called Nrf2 which signals release of glutathione and has a role, like B3, in autophagy.
WHAT IS AUTOPHAGY, ANYWAY 🤔
“Autophagy is essentially a pro-survival, catabolic process in response to stress stimuli.
It is a recycling mechanism by which cells digest damaged constituents and/or organelles and recycle the nutrients back to the cell for essential processes.
Autophagy is a genetically regulated and dynamic process associated with the formation of autophagosome.”
“Autophagy is essentially a pro-survival, catabolic process in response to stress stimuli.
It is a recycling mechanism by which cells digest damaged constituents and/or organelles and recycle the nutrients back to the cell for essential processes.
Autophagy is a genetically regulated and dynamic process associated with the formation of autophagosome.”
SUPPLEMENT IDEAS TO SUPPORT NAD & AUTOPHAGY
for informational purposes only
Please note, I do not prescribe or sell supplements.
for informational purposes only
Please note, I do not prescribe or sell supplements.
Forwarded from Heather Rae, Functional Health Practitioner
Introduction to The Longevity Wheel
https://youtu.be/flwtupQD3HQ
https://youtu.be/flwtupQD3HQ
YouTube
Introduction to The Longevity Wheel
Forwarded from David Avocado Wolfe
Rockefeller Foundation ‘Reset the Table’ Report Predicted COVID-Related Food Crisis — 2 Years Before It Happened
On July 28, 2020, the Rockefeller Foundation issued a report predicting the food crisis and offering up solutions, including “shifts to online enrollment and online purchasing of food.” The foundation described “a hunger and nutrition crisis … unlike any this country has seen in generations.”
https://childrenshealthdefense.org/defender/rockefeller-foundation-reset-the-table-covid-food-shortage-crisis/
On July 28, 2020, the Rockefeller Foundation issued a report predicting the food crisis and offering up solutions, including “shifts to online enrollment and online purchasing of food.” The foundation described “a hunger and nutrition crisis … unlike any this country has seen in generations.”
https://childrenshealthdefense.org/defender/rockefeller-foundation-reset-the-table-covid-food-shortage-crisis/
Forwarded from Dennis Dvernychuk
Rumble
Ricardo Delgado - VACCINES, GRAPHENE Oxide, NANOTECH and 5G
Credits to The Sage of Quay™ Radio Hour | June 28th, 2022 Ricardo Delgado - VACCINES, GRAPHENE Oxide, NANOTECH and 5G: thtps://odysee.com/@sageofquay:0/Ricardo-Delgado-Interview-1:1 My website is avai
IVERMECTIN & THE BIOINDIVIDUALITY OF GENES: UNEXPECTED DRUG RESPONSES
This post goes out to all the people pushing ivermectin for a non-existent pathogen, a ‘virus’ called SARS-COV.
You owe it to yourself, and others, to know a bit about how compounds like ivermectin clear, biochemically. If I can wade into this stuff, so can you 🤓
A young boy was given ivermectin and had a terrible reaction (neurologic signs, including coma, ataxia, pyramidal signs, and binocular diplopia, as well as abdominal pain and vomiting); here is the clinician’s very detailed, bioindividual, assessment.
Some background ...
The body clears toxins, aka drugs, in stages, phases. The first phase is called Phase I, go figure; it uses compounds called CYP, and there are lots of them, acting on specific toxins, drugs, compounds.
Ivermectin is cleared via CYP3A4/5.
A gene called ABCB1 makes a glycoprotein that transports (carries) these drugs (referred to as substrates). Many drugs can use this same transporter/carrier/glycoprotein. Variants in the ABCB1 gene can lead to sub-optimal transportation (clearing) of the drugs.
Ivermectin is transported by ABCB1.
The interesting part about this clinical paper, “Serious Ivermectin Toxicity and Human ABCB1 Nonsense Mutations” is the sensitivity to drugs like ivermectin in certain breeds of dogs like collies, the breed my family had going back to the 50s. (Just kidding, that isn’t the interesting part.).
Check out the “Supplementary Appendix” which includes three charts (pages 5-7) showing compounds that use CYP3A4/5, the CYP that clears ivermectin, and ABCB1, its transporter.
You will see paracetamol, statins, warfarin, caffeine, codeine, cortisol, cannabadiol, THC, midazolam, caffeine, licorice, grapefruit, St John’s Wort, and milk thistle, too.
A ‘perfect storm’ could be taking ivermectin when there are other drugs competing for CYP and ABCB1, and variants in the gene that makes ABCB1 so there isn’t enough on board to transport the whole toxic burden, and where other drugs are inhibiting or inducing the effects of ivermectin.
In short the body is overloaded, leading to,what the clinicians call ‘ivermectin intoxication.’
It is irresponsible, and dangerous, to tell people to take drugs (of whatever kind) without knowing someone's bioindividuality. And it is just straight up stupid to take drugs for a pathogen that doesn't even exist.
drug interactions
P-glycoprotein (Pgp, ABCB1) and
cytochrome P450 (CYP3A4, CYP3A5)
https://www.nejm.org/doi/10.1056/NEJMc1917344
This post goes out to all the people pushing ivermectin for a non-existent pathogen, a ‘virus’ called SARS-COV.
You owe it to yourself, and others, to know a bit about how compounds like ivermectin clear, biochemically. If I can wade into this stuff, so can you 🤓
A young boy was given ivermectin and had a terrible reaction (neurologic signs, including coma, ataxia, pyramidal signs, and binocular diplopia, as well as abdominal pain and vomiting); here is the clinician’s very detailed, bioindividual, assessment.
Some background ...
The body clears toxins, aka drugs, in stages, phases. The first phase is called Phase I, go figure; it uses compounds called CYP, and there are lots of them, acting on specific toxins, drugs, compounds.
Ivermectin is cleared via CYP3A4/5.
A gene called ABCB1 makes a glycoprotein that transports (carries) these drugs (referred to as substrates). Many drugs can use this same transporter/carrier/glycoprotein. Variants in the ABCB1 gene can lead to sub-optimal transportation (clearing) of the drugs.
Ivermectin is transported by ABCB1.
The interesting part about this clinical paper, “Serious Ivermectin Toxicity and Human ABCB1 Nonsense Mutations” is the sensitivity to drugs like ivermectin in certain breeds of dogs like collies, the breed my family had going back to the 50s. (Just kidding, that isn’t the interesting part.).
Check out the “Supplementary Appendix” which includes three charts (pages 5-7) showing compounds that use CYP3A4/5, the CYP that clears ivermectin, and ABCB1, its transporter.
You will see paracetamol, statins, warfarin, caffeine, codeine, cortisol, cannabadiol, THC, midazolam, caffeine, licorice, grapefruit, St John’s Wort, and milk thistle, too.
A ‘perfect storm’ could be taking ivermectin when there are other drugs competing for CYP and ABCB1, and variants in the gene that makes ABCB1 so there isn’t enough on board to transport the whole toxic burden, and where other drugs are inhibiting or inducing the effects of ivermectin.
In short the body is overloaded, leading to,what the clinicians call ‘ivermectin intoxication.’
It is irresponsible, and dangerous, to tell people to take drugs (of whatever kind) without knowing someone's bioindividuality. And it is just straight up stupid to take drugs for a pathogen that doesn't even exist.
drug interactions
P-glycoprotein (Pgp, ABCB1) and
cytochrome P450 (CYP3A4, CYP3A5)
https://www.nejm.org/doi/10.1056/NEJMc1917344
Forwarded from The Way Forward (Alec Zeck)
Yet another scientist, and in this case a virologist, speaking about how *there is no virus*: https://www.bitchute.com/video/btuJXs0glmla/
Bitchute
The Scamdemic: Covid 19 - SARS COV2 the Virus that Never Existed
Poornima Wagh, 2 PhDs in Virology and Immunology, 20 yr career as a Lab researcher and scientist, destroys the Covid scam with proof in language even a layman like me can understand. Who benefits? Big Pharma and its owners (not shareholders), Gates, Fauci…