for the Robert Gs ... to answer your questions about David Sinclair’s longevity protocol and his take on NAD, a form of B3, it helps to see NAD in context, what it is doing and where in the inflammation, detoxification processes. You will see compounds like resveratrol, and compounds that effect/inhibits nNOS (nitric oxide synthase) like spermidine. Let’s just say, regarding the “Lifespan” protocol, ‘your mileage may differ’ depending on your own terrain: what are your toxin burdens, nutrient levels, variants in these enzymes (genes), cellular pH, minerals, salts/sugars. There are tests (urine, saliva) to tell you this information. You can enlarge these graphics to see NAD+ specifically, as well as NOS.

PATHWAYS AND THE NADPH STEAL

PHASE II UREA CYCLE & AUTOPHAGY MAP

AUTOPHAGY, MTOR & NAD

RANTES INFLAMMATION (NFKb, TNFa)

for Robert G....
https://draxe.com/health/heavy-metal-detox/ (detox with extreme caution, give your DNA detox analysis to detox clinic/practitioner)
https://www.greatplainslaboratory.com/gpl-tox (urine non-heavy metal test - include glyphosate, mycotoxins in panel if you can afford it)
https://pubmed.ncbi.nlm.nih.gov/31610392/ (toenail test for trace minerals)
Gorgi Dinkov (he has a lab to test toenail for heavy metals, otherwise use Trace Elements’ HMTA - hair test or Xyto energy test)
Dinkov videos: https://youtu.be/zttlgAngBZc
https://youtu.be/WPd9pteoETo

https://draxe.com/health/heavy-metal-detox/ (detox with extreme caution, give your DNA detox analysis to detox clinic/practitioner)

UP CLOSE ... inflammation around TNFa, NFkB You got your glyphosate, mycotoxins, borrelia, citrinin, oxalates, heavy metals (and suggested natural and pharma compounds to block inflammatory response). You can’t pill-pop and supplement your way out of the inflammation; you are going to have to get out the toxins, clean up diet and environment

The citations (studies, primarily on rodents) are basis of Sinclair's lifespan protocol: autophagy, blood sugar management, inflammation reduction using compounds (resveratrol, spermidine, Metformin, NMN) acting on various enzymes (NOS, SIRT) and inflammatory NFkb. https://www.science.org/doi/10.1126/science.aan2788

Variants in NOS, SIRT, FOXO, and lipid metabolism (FADS), among other genes (enzymes) will influence the whole shebang but his protocol doesn't account for bioindividuality.

follow 👉 t.me/HeatherRaeFunctionalHealth

hmmm! "Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance."
There goes my already very lame defense of my red wine habit.

A QUICK NOTE ABOUT SPERMIDINE. It is tightly controlled in the body because it converts into hydrogen peroxide and acrolein which is a nasty toxin. You need SAM (a methyl donor) to make it. It is a polyamine (made up of many 'amines' which is broken down by an enzyme called DAO). It is ubiquitous in the body and necessary for growth. The body can make spermidine (from arginine); you can get enough of it in your diet and from microbiota in the gut.
Here is the rub.
The biochemistry of polyamines is coordinated, tightly choreographed.
Supplementing with spermidine when you have weaknesses (variants) in the enzymes that move this compound along in its tightly controlled chemistry (methylation, acetylation, catalase, glutathione) and disturbances in gut bacteria could lead to excess toxins like acrolein (see my posts above about acrolein from.polyglycol)