Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1256033/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1256033/
PubMed Central (PMC)
Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).
Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes phosphatidylcholine synthesis. PEMT knockout mice have fatty livers, and it is possible that, in humans, nonalcoholic fatty liver disease (NAFLD) might be associated with PEMT gene polymorphisms.…
Sunflower PC PE PI – Professional Health Products®
https://professional-health-products.com/product/sunflower-pc-pe-pi/
https://professional-health-products.com/product/sunflower-pc-pe-pi/
Professional-Health-Products
Sunflower PC PE PI – Professional Health Products®
CHOLINE/PEMT SUPPORT you might consider this PC/PE/PI for variants in PEMT but it is made from sunflower seeds which are a PUFA and not so great (not at all) if you have insulin/blood sugar issues. (I have variants in PEMT and have evidence that lecithin is not my friend ... you may respond differently, of course!)
Fatty Acid Assist™ – Professional Health Products®
https://professional-health-products.com/product/fatty-acid-assist/
This blend includes fennel, dandelion and B2 ... which gives you a good idea on how to support fat/lipid metabolism via diet!.
https://professional-health-products.com/product/fatty-acid-assist/
This blend includes fennel, dandelion and B2 ... which gives you a good idea on how to support fat/lipid metabolism via diet!.
Professional-Health-Products
Fatty Acid Assist™ – Professional Health Products®
I HAVE BEEN ACCUSED OF 'SELLING SUPPLEMENTS' (though I think the person who said that about me and my genomics practice was looking for a way out of the deep dive into her health issues, and quite deep already in the pharma trif***ta mentality.)
I DO NOT SELL 'PRODUCT' ... these supplements above are suggestions from a product line you may not know, as they are designed for functional genomics. My clients can source their food and supplements however they wish, and I encourage strongly that those sources be of very high quality and reputation! I do not support, and certainly do not sell, any MLM products!!
I DO NOT SELL 'PRODUCT' ... these supplements above are suggestions from a product line you may not know, as they are designed for functional genomics. My clients can source their food and supplements however they wish, and I encourage strongly that those sources be of very high quality and reputation! I do not support, and certainly do not sell, any MLM products!!
Expanding the list of untimely deaths: Nicholas Gonzales, Kary Mullis, David Crowe 👇👇👇👇
Xeno-estrogens (plastics in masks, test swabs, water bottles ... and oh, yea, straws) are also endocrine (sex hormone) disruptors.
ESTROGEN, COPPER, STRESS, HYPOXIA, METABOLIC DYSFUNCTION ... and the genes of iron, copper, zinc, B vitamins
A functional.genomic analysis looks at enzymes (genes/proteins) involved in movement of these compounds in and out of the cell. For example, there is a gene that makes a compound that transports iron out of the cell; when variated and downregulated, iron gets stuck in cell and the iron buildup can be damaging. When you also have issues with the removal of superoxide from variants in superoxide dismutase (SOD), that iron can combine with superoxide to make hydroxyl radicals. That is called the Fenton reaction and is quite harmful to the cell.
A functional.genomic analysis looks at enzymes (genes/proteins) involved in movement of these compounds in and out of the cell. For example, there is a gene that makes a compound that transports iron out of the cell; when variated and downregulated, iron gets stuck in cell and the iron buildup can be damaging. When you also have issues with the removal of superoxide from variants in superoxide dismutase (SOD), that iron can combine with superoxide to make hydroxyl radicals. That is called the Fenton reaction and is quite harmful to the cell.
Forwarded from Danny Roddy
Ceruloplasmin: The Emergency "Acute Phase Reactant" Liver Protein Increased by Estrogen, Stress, and Infection
In general, acute phase reactants rise in response to injury. I think the chronic elevation of these substances (e.g., ferritin, CRP, TNF-a, etc.), while defensive, would indicate a pathological process.
"...Despite gallant efforts by numerous laboratories and investigators, no single factor has emerged as indispensable for mediating copper passage into cells in vivo. This apparent failure allows one to question whether delivery of an essential nutrient would be expected to depend on a single component. Thus, it is more likely that cells have evolved numerous ways for absorbing copper from their immediate surroundings. This would imply that numerous carriers, including ceruloplasmin and albumin, have the potential to behave as copper transporters."
— Harris E. Cellular copper transport and metabolism. Annu Rev Nutr. 2000;20:291-310.
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"Plasma ceruloplasmin, a copper-containing protein, belongs to a class called acute phase proteins...."
"Stress was known to increase Ceruloplasmin."
"We found lowest ceruloplasmin level after stress in overiectomised animals, while on substitution of estradiol the trend appeared to be reversed. The result suggested a direct effect of estrogen on hepatic ceruloplasmin production/release..."
— Ganaraja B., et al. Effect of estrogen on plasma ceruloplasmin level in rats exposed to acute stress. (2004)
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"In conclusion, serum ceruloplasmin level is elevated in the subjects with metabolic syndrome, as well as in subjects with impaired glucose regulation or diabetes mellitus. In addition, serum ceruloplasmin level is associated with various cardiovascular risk factors. These results suggest that elevated serum ceruloplasmin level can be a marker for metabolic stresses associated with metabolic syndrome."
— Kim C., et al. Elevated serum ceruloplasmin levels in subjects with metabolic syndrome: a population-based study. (2002)
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"...Plasma caeruloplasmin values were similar in the kindergarten and Health Centre children with infection, but those with chronic infection had significantly higher values than the others..."
— Ismadi S., et al. Usefulness of plasma ceruloplasmin and transferrin levels in the assessment of protein calorie malnutrition among pre-school children. (1971)
-------
"Ceruloplasmin level, a marker of hepatic estrogen metabolism, was significantly elevated in patient groups receiving both dosages of oral estrogen..."
— Alkjaersig N., et al. Blood coagulation in postmenopausal women given estrogen treatment: comparison of transdermal and oral administration. (1988)
-------
"We studied the presence of a different responsiveness of the human liver to the estrogens in two groups of post-menopausal women by evaluating the changes in ceruloplasmin serum level. Conjugated equine estrogens were administered at different times (A: 8 a.m. and B: 8 p.m.). The replacement therapy increased ceruloplasmin serum levels both in group A and B, but the increase was higher in group B than in group A."
— Clemente C., et al. Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times. (1992)
-------
Q: When estrogen increases ceruloplasmin do you see that as a defensive reaction to hypoxia?
A: "I think so, helping to keep iron in an oxidized state." Ray Peat, PhD (2022)
In general, acute phase reactants rise in response to injury. I think the chronic elevation of these substances (e.g., ferritin, CRP, TNF-a, etc.), while defensive, would indicate a pathological process.
"...Despite gallant efforts by numerous laboratories and investigators, no single factor has emerged as indispensable for mediating copper passage into cells in vivo. This apparent failure allows one to question whether delivery of an essential nutrient would be expected to depend on a single component. Thus, it is more likely that cells have evolved numerous ways for absorbing copper from their immediate surroundings. This would imply that numerous carriers, including ceruloplasmin and albumin, have the potential to behave as copper transporters."
— Harris E. Cellular copper transport and metabolism. Annu Rev Nutr. 2000;20:291-310.
-------
"Plasma ceruloplasmin, a copper-containing protein, belongs to a class called acute phase proteins...."
"Stress was known to increase Ceruloplasmin."
"We found lowest ceruloplasmin level after stress in overiectomised animals, while on substitution of estradiol the trend appeared to be reversed. The result suggested a direct effect of estrogen on hepatic ceruloplasmin production/release..."
— Ganaraja B., et al. Effect of estrogen on plasma ceruloplasmin level in rats exposed to acute stress. (2004)
-------
"In conclusion, serum ceruloplasmin level is elevated in the subjects with metabolic syndrome, as well as in subjects with impaired glucose regulation or diabetes mellitus. In addition, serum ceruloplasmin level is associated with various cardiovascular risk factors. These results suggest that elevated serum ceruloplasmin level can be a marker for metabolic stresses associated with metabolic syndrome."
— Kim C., et al. Elevated serum ceruloplasmin levels in subjects with metabolic syndrome: a population-based study. (2002)
-------
"...Plasma caeruloplasmin values were similar in the kindergarten and Health Centre children with infection, but those with chronic infection had significantly higher values than the others..."
— Ismadi S., et al. Usefulness of plasma ceruloplasmin and transferrin levels in the assessment of protein calorie malnutrition among pre-school children. (1971)
-------
"Ceruloplasmin level, a marker of hepatic estrogen metabolism, was significantly elevated in patient groups receiving both dosages of oral estrogen..."
— Alkjaersig N., et al. Blood coagulation in postmenopausal women given estrogen treatment: comparison of transdermal and oral administration. (1988)
-------
"We studied the presence of a different responsiveness of the human liver to the estrogens in two groups of post-menopausal women by evaluating the changes in ceruloplasmin serum level. Conjugated equine estrogens were administered at different times (A: 8 a.m. and B: 8 p.m.). The replacement therapy increased ceruloplasmin serum levels both in group A and B, but the increase was higher in group B than in group A."
— Clemente C., et al. Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times. (1992)
-------
Q: When estrogen increases ceruloplasmin do you see that as a defensive reaction to hypoxia?
A: "I think so, helping to keep iron in an oxidized state." Ray Peat, PhD (2022)