💥Ketorolac is notable as a drug used mainly as a systemic analgesic, not as an anti-inflammatory.
💥It is the only NSAID available in a parenteral formulation.
💥has greater analgesic effectiveness.
💥It is the only NSAID available in a parenteral formulation.
💥has greater analgesic effectiveness.
🐰Nonselective NSAIDs reduce polyp formation in patients with primary familial adenomatous polyposis.
🐰Long-term use of NSAIDs reduces the risk of colon cancer.
🐰Long-term use of NSAIDs reduces the risk of colon cancer.
🤒The major difference between the mechanisms of action of aspirin and other NSAIDs is that aspirin (but not its active metabolite, salicylate) acetylates and thereby irreversibly inhibits cyclooxygenase, whereas the inhibition produced by other NSAIDs is reversible.
🤕The irreversible action of aspirin results in a longer duration of its antiplatelet effect and is the basis for its use as an antiplatelet drug.
🤕The irreversible action of aspirin results in a longer duration of its antiplatelet effect and is the basis for its use as an antiplatelet drug.
😔Aspirin or salicylate toxicity lead to death by respiratory failure.
👽Acetaminophen (Paracetamol) toxicity lead to death by liver failure.
👽Acetaminophen (Paracetamol) toxicity lead to death by liver failure.
💥Celecoxib is a COX-2-selective inhibitor. Although the COX-2 inhibitors have the advantage over nonselective NSAIDs of reduced gastrointestinal toxicity, clinical data suggest that they are more likely to cause arterial thrombotic events.
☄A history of myocardial infarction would be a compelling reason to avoid a COX-2 inhibitor.
☄A history of myocardial infarction would be a compelling reason to avoid a COX-2 inhibitor.
💥Aspirin an irreversible COX inhibitor, is particularly effective. Because platelets lack the machinery for synthesis of new protein, inhibition by aspirin persists for several days until new platelets are formed.
Other NSAIDs, which cause a less persistent antiplatelet effect (hours), are not used as antiplatelet drugs and, in fact, can interfere with the antiplatelet effect of aspirin when used in combination with aspirin.
Other NSAIDs, which cause a less persistent antiplatelet effect (hours), are not used as antiplatelet drugs and, in fact, can interfere with the antiplatelet effect of aspirin when used in combination with aspirin.
♦️Dipyridamole combined with aspirin for secondary prevention of ischemic stroke.
🐰Bivalirudin Used with aspirin in unstable angina when undergoing percutaneous transluminal coronary angioplasty (PTCA).
🐰Bivalirudin Used with aspirin in unstable angina when undergoing percutaneous transluminal coronary angioplasty (PTCA).
👉vasopressin acts through V2 receptors to increase the insertion of water channels in the apical membranes of collecting duct cells in the kidney and to thereby provide an antidiuretic effect.
👉Extrarenal V2-like receptors regulate the release of coagulation factor VIII and von Willebrand factor .
☄Desmopressin, a selective agonist of V2 receptors, is administered orally, nasally, or parenterally in patients with pituitary diabetes insipidus and in patients with mild hemophilia A or von Willebrand disease. Because it increases the plasma concentration of von Willebrand factor and factor VIII.
👉Extrarenal V2-like receptors regulate the release of coagulation factor VIII and von Willebrand factor .
☄Desmopressin, a selective agonist of V2 receptors, is administered orally, nasally, or parenterally in patients with pituitary diabetes insipidus and in patients with mild hemophilia A or von Willebrand disease. Because it increases the plasma concentration of von Willebrand factor and factor VIII.
⚡️Dabigatran
👉Oral anticoagulant that does not require monitoring of PT or INR.
👉Used in atrial fibrillation as an alternative to warfarin
👉Rapidly reversed by idarucizumab (its antidote ).
👉Oral anticoagulant that does not require monitoring of PT or INR.
👉Used in atrial fibrillation as an alternative to warfarin
👉Rapidly reversed by idarucizumab (its antidote ).
ال warfarin نستخدمه ضد ال thrombosis ليش لوما نعطوه بعض الاحيان يعمل thrombosis او Hypercoagulability في بداية استخدامه ؟
👉Transient protein C deficiency can be induced when initiating treatment with warfarin because factors VII and protein C have the shortest half lives of the coagulation factors.
👉Hypercoagulability occurs, which may result in dermal vascular thrombosis and skin necrosis.
👉Transient protein C deficiency can be induced when initiating treatment with warfarin because factors VII and protein C have the shortest half lives of the coagulation factors.
👉Hypercoagulability occurs, which may result in dermal vascular thrombosis and skin necrosis.
👉Endemic (disease present at fairly low, but constant, level).
👉Epidemic (infection greater than normally occurs in the population).
👉Pandemic (infections that are spread worldwide involving a novel virus and person-to-person spread).
👉Epidemic (infection greater than normally occurs in the population).
👉Pandemic (infections that are spread worldwide involving a novel virus and person-to-person spread).