Yes, we know you want to know what is the most important thing Telegram Freaks need to do, but sorry, you need to wait.

Let we check what is the second most important thing you can do on Telegram: for sure be able to manage storage in proper way!
Ok, and now? How can i do that?

The answer is pretty simply. It depends which MacOS app are you using. If you are using Telegram for MacOS (Stable or Beta Apple CPU compatible or not), you need to change the following option:

Setting / Data and Storage / Storage Usage —> Maximum cache size to the minimum and auto remove after 1 day for all three options.
If you are using Telegram Desktop based Mac Apps (Bettergram, Desktop, Kotatogram, iMe, Telegreat, Telegram Lite, Desktop Beta), then you need to change at least one option:

1: Setting / Advanced / Manage Local Storage —> minimum

2: Setting / Advanced / Automatic Media Download / In private chats / groups / channels —> optionally you can turn that off
Get additional tips and suggestion, even to discover Telegram channels @BetterTelegramUsage
One of the worse thing a Telegram user can do is thinking "i don't need two Mac Apps!". Never and again NEVER! use just one Mac App, except if you want to be like average users missing 50% of the features without even be able to find Telegram channels properly! Both apps are totally different and cannot be considered as alternative.
True TikTokFreaks should already know that both apps are necessary for a proper usage, but Telegram Stable / Beta remain without discussion the winner!