The compound, called oxalate, is abundant in foods such as spinach, almonds, and sweet potatoes. It is best known for contributing to certain kidney stones, but new research suggests that oxalate left inside the digestive tract may also aggravate intestinal inflammation in people with Crohn’s disease or ulcerative colitis.

Published in Cellular and Molecular Gastroenterology and Hepatology (CMGH), the study combined patient data with experiments in mice and cultured immune cells. The work was led by postdoctoral scholar Anna Salvador, PhD, RD, LDN, in the laboratory of Shehzad Z. Sheikh, MD, PhD, professor of medicine and genetics at the UNC School of Medicine.

When bacteria invade the urinary tract, the body has its own arsenal for fighting back. Among those weapons is an unlikely tool: copper. Researchers at the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS) are investigating how the body uses the essential trace mineral to fight urinary tract infections (UTIs), how bacteria manage to survive that attack and whether those discoveries could eventually lead to new ways of treating infections that are increasingly difficult to control with antibiotics.

The research builds on previous findings from the lab of Dr. Sarguru Subash, an associate professor in the VMBS Department of Veterinary Pathobiology, showing that the body pumps copper into the urinary tract during infection to kill UTI-causing bacteria.

"We know that copper plays an important role, but that also raises so many questions about how these pathogens adapt to the presence of increased copper," Subash said.

"If we better understand how the bacteria overcome the host-imposed copper resistance, then we can develop therapies that make the bacteria more susceptible to copper and, more broadly, to everything that the immune system throws at them."

Turning a nutrient into a weapon
Copper is an essential nutrient for both people and animals, but in the right environment and concentration, it can also be toxic to bacteria.

The immune system takes advantage of that property when responding to infection.

As part of the body's early, or innate, immune response, specialized immune cells can engulf invading bacteria and expose them to an antimicrobial mixture that includes copper. During a UTI, Subash's previous research has shown that the body increases copper levels in the urine.

But bacteria aren't defenseless. Because they encounter copper naturally in the environment, many bacteria have evolved mechanisms that allow them to remove or detoxify the metal.

"Bacteria do have adaptations, but when it's presented in the context of this cocktail, the bacterial defense mechanisms are not as effective," Subash said. "Sometimes the balance tips in favor of the host, so we can control the infections. Other times, the balance tips in favor of pathogens. As a result, we get clinical disease."

That creates what Subash describes as a tug-of-war between the host and pathogen: Sometimes, the immune system successfully controls bacterial growth before it causes noticeable illness; other times, bacteria overcome those defenses, allowing an infection to become established.

Understanding what tips that balance could reveal new vulnerabilities that researchers can target to control bacterial infections.

Sometimes your eyes need a minute to focus when you wake up. Roman's Wide Field Instrument just woke up for the first time EVER, and scientists have started adjusting its "eyes" so they can focus on the bigger picture. Check out its first test image above.

NASA’s Nancy Grace Roman Space Telescope team has successfully activated the Wide Field Instrument, a 300-megapixel infrared camera that will allow scientists to explore wide swaths of the cosmos very quickly without sacrificing exquisite detail.

Roman’s planet imager — the Coronagraph Instrument — also stretched its digital, electronic, and mechanical “limbs” as part of an initial test after waking up earlier this month.

These steps are part of a monthslong series of calibrations and tests, as Roman continues its million-mile journey to its destination at the second Lagrange point, L2.

Read more go.nasa.gov/4j51w30

The Nancy Grace Roman Space Telescope hasn't yet reached its Sun-Earth L2 orbit and it already has some good news. NASA has announced that the mission has enough fuel to potentially double its mission length. Though initially scheduled for five years of initial observations, followed by a five year extended mission, the entire mission length could now reach 22 years.

“As a result of exquisite planning by our orbital dynamics team, brilliant execution by the operations team, and a precise launch from SpaceX, Roman has fuel for at least 22 years of potential science operations,” said Jamie Dunn, center director at NASA’s Goddard Space Flight Center in Greenbelt, Maryland.

Fuel is the Roman's only consumable resource and is the limiting factor for mission length. Several things contributed to its new, extended mission length, starting with the precise launch. The SpaceX Falcon Heavy helped set the stage with its accurate low-Earth orbit departure burn. The more accurate this is, the less fuel is required for the Roman's subsequent burns.

The next reason is the spacecraft's actual weight vs planned weight.

“A spacecraft’s mass changes throughout the design and build process, so we base the propellant budget on a set maximum value so we won’t come up short,” said Alison Rao, the Roman propulsion lead at NASA Goddard. “We track the propellant needed based on actual mass throughout integration and testing as well, to make sure we have wiggle room. Since Roman’s was lower than we budgeted for, we were able to fill the propellant tanks to their capacity rather than only filling them as much as we needed to for the 10-year requirement.”

A study by researchers at Columbia University Vagelos College of Physicians and Surgeons has found that new cutting-edge techniques can accurately edit genes in human embryos—giving scientists indispensable tools for understanding normal human development—but has also uncovered important risks that currently preclude the use of the techniques in the clinic.

Editing the genome is an essential technique for scientists seeking to understand the genome. Editing genes in human embryos allows us to understand the earliest steps of human development. Early human embryos accrue a surprising amount of DNA damage as they grow, and most human embryos made with IVF stop their development in the first few days.

"By introducing such damage using editors, we are starting to understand how human embryos handle damage in their genomes. In the long term, we hope to learn how to prevent genetic and developmental abnormalities during IVF to create more efficient, safer and more affordable fertility treatments," says Dieter Egli, the study's leader and associate professor of developmental cell biology in the Department of Pediatrics.

In the study, published Sept. 9 in Nature, Egli's team used base editing—a more meticulous genetic editor than earlier techniques—to make changes in individual letters in the DNA of single-cell human embryos. They then followed each embryo's development for 6–7 days (a stage when IVF embryos can be implanted) to determine if the edit was made correctly and passed on to all cells in the embryo. Remarkably, in some experiments, the editing was 100% successful and development was apparently normal.

But the editing sometimes caused unpredictable changes and is not safe to use in the clinic. Editing human embryos has the potential to give people who carry disease-causing mutations an opportunity to have healthy children through IVF. "But given our findings, it is currently not possible to do so safely," says Egli.

"As a scientist, the first goal is to uncover new knowledge, which we hope will lead to new ways to help people. But identifying the risks is just as important because it draws the boundaries for meaningful use of a powerful technology. I think our study will discourage inappropriate use of these techniques in the clinic because we clearly demonstrate the risks."

Given that it's the closest planet to the sun, Mercury seems like it should be the hottest planet in our solar system.

However, at a blistering 900 degrees Fahrenheit (480 degrees Celsius), Venus tops Mercury's 800 F (430 C) highest surface temperature, despite being an average of 31 million miles (50 million kilometers) farther from the sun. So how can the second planet from our star be hotter than the closest planet to it?

It all comes down to reflectivity, atmospheric composition and geological history, experts told Live Science.

Totally different atmospheres
A planet's distance from its star is not the only factor that influences the planet's temperature.

"Distance tells us how much sunlight arrives at a planet, but it does not tell us how much is reflected … absorbed, how efficiently heat escapes, or how effectively the atmosphere transports heat around the planet," Stephen Kane, an astrophysicist who studies planetary habitability at the University of California, Riverside, told Live Science in an email. "Those properties can be just as important as distance, and sometimes much more important."

Mercury makes the case in miniature. According to Kane, the planet has essentially no atmosphere, so incoming sunlight strikes bare rock directly, heating it to extreme temperatures during the day. But with barely anything overhead to trap that warmth, Mercury radiates it straight back into space the moment the sun sets. As a result, nighttime temperatures plunge from roughly 800 F (430 C) during the day to about minus 290 F (minus 180 C) at night — a swing of well over 1,000 degrees, he added.

Venus tells the opposite story. Wrapped in an atmosphere that's roughly 90 times as dense as Earth's and consists almost entirely of carbon dioxide, Venus traps heat so effectively that its surface temperature barely changes at all, no matter where the sun happens to be, Kane explained...

Tyrannosaurus rex was a hottie with a body temperature similar to our own, according to a new analysis of their teeth. MThe finding supports the idea that T. rex was a fast, energetic predator and scavenger, not an animal that basked in the sun to gain energy like most modern-day reptiles.

T. rex, which lived between about 68 million and 66 million years ago, at the end of the Cretaceous period (143.1 million to 66 million years ago), was one of the largest carnivorous dinosaurs that ever lived.

Previous studies have already suggested that T. rex and its relatives were warm blooded, but now scientists have estimated the dinosaur's body temperature for the first time by studying different isotopes, or forms, of the same chemical elements in the enamel of three T. rex teeth from specimens found in the Hell Creek Formation in Montana.

Rare, heavy isotopes of carbon and oxygen bond together differently in growing tooth enamel depending on the temperature. The number of bonds formed between these rare isotopes is greater at cooler temperatures than it is at warmer temperatures, which means warm-blooded, or endothermic animals, that can regulate their own body temperature, have fewer of these chemical bonds in their teeth than cold-blooded, or ectothermic, animals, which rely on their environment for warmth...

Have you ever bought something not because you wanted it, but because you were afraid of what might happen if you didn't? Maybe you worried about looking older, falling behind at work or simply not fitting in.

While marketing often promises an aspirational lifestyle, some of the most effective campaigns work in the opposite direction: making you feel bad about your current reality, then presenting a product as the solution.

This is the logic of pain-point advertising, and emotions are central to its effectiveness.

Emotional content in advertising can be framed positively or negatively. When advertisers choose to frame it negatively, they aim to show that not using their product could lead to negative experiences, often illustrated by the characters' negative emotions in the ad.

How pain-point advertising works
Companies that develop goods and services need to establish a presence in the market, stimulate consumer demand and generate profits. Advertising uses a range of strategies to achieve those goals, but emotional content remains a staple across the industry.

Research in cognitive and behavioral science suggests that consumers don't make decisions through rational calculation alone, and that emotions play an important role.

One reason may be the way our brains make sense of the world. The human brain is a predictive machine that constantly uses past experiences to anticipate what will happen next.

Throughout our lives, we accumulate experiences that help us form increasingly accurate expectations and make better decisions. When our experiences confirm those expectations, there is little reason for the brain to change course. We can continue relying on what we already know.

But when reality contradicts what we expected, the mismatch can trigger a negative emotional response. The discrepancy signals that something about our expectations or behavior may need to change.

This is the very mechanism that pain-point advertising exploits. For instance, an advertisement might draw attention to a gap between how we see ourselves and how we believe we should look. The advertised product is then presented as a way to close that gap...

Webb reveals one of its largest images to date! 😲

This starry view shows the nearby star-forming region IC 348. Here, astronomers searched for brown dwarfs, objects which are less massive than the smallest stars. Read more 👉 esa.int/Science_Explor…

High quality in comments

X-ray technology and artificial intelligence—along with the discovery of lead in the ink of fragments from a collection of ancient Roman scrolls—could soon help scientists read long-lost texts buried by the eruption of Mount Vesuvius in 79 CE, according to a study published Sept. 16, 2026, in the journal PLOS One by Douglas Seiler, an affiliate of the University of California, Berkeley, U.S.; Jacob Michael LaManna of the National Institute of Standards and Technology, U.S.; David Kreimer of the University of California, Berkeley, U.S.; and colleagues.

The Herculaneum papyri scrolls were discovered in the ruins of the town of Herculaneum, near Naples, Italy. During the volcanic eruption, the scrolls were covered by 65–70 feet (20–21 meters) of rock and ash, "carbonizing" them in the extreme heat and making them very brittle. While some of the scrolls have been opened and read, revealing previously unknown writings by Epicurus and other ancient thinkers, many have proven too fragile to study.

Lead offers a clearer signal
Recently, AI and X-ray tomography have allowed researchers to virtually "unroll" some of the scrolls and read some of the text. That said, X-rays can have a hard time distinguishing the text because the ink and papyrus are made of similar materials: carbon. But some of the Herculaneum scroll letters have been found to contain lead. Since X-rays can more easily distinguish between papyrus and lead, the authors of this new paper suggest scanning the scrolls for lead and then attempting to virtually unroll those that contain it.

To test this, the team recreated some carbonized scrolls by writing on new papyrus using ink with various concentrations of lead, then heating the scrolls in a high-temperature furnace and carbonizing them. X-ray fluorescence was able to detect lead in the scrolls at each lead concentration level, and X-ray tomography, combined with a custom software program, allowed the team to reread some of the words they had written on these scrolls.

For centuries, scientists have thought of the brain as a single, unified organ. But new research led by Stanford Medicine reveals that what we call the brain is two distinct organs that evolved independently over hundreds of millions of years.

The discovery overturns a prevailing model of brain development. For decades researchers have subscribed to the theory that there is a single progenitor cell early in development that gives rise to the entire brain. This model suggested all parts of the brain shared a common developmental origin.

The new research finding shows that the human brain consists of two ancient nervous systems cleverly packaged together — a more primitive part that regulates our hearts’ beating, our breathing and other functions, and another that makes us distinctly human, capable of poetry, mathematics and wondering about our own origins.

The discovery could help explain why scientists have struggled for decades to grow certain types of brain cells in the laboratory — and it opens new avenues for studying devastating diseases that affect the brain stem, such as spinal muscular atrophy (also known as SMA) and amyotrophic lateral sclerosis (also known as ALS or Lou Gehrig’s disease).

“We’ve shown for the first time that the front of the brain arises from a totally different progenitor cell than the back of the brain,” said Kyle Loh, PhD, associate professor of developmental biology. “Our discovery means that we can now grow neurons from the back of the brain, the hindbrain, in a petri dish and study their functions.”

Two brains
The adult brain has three main regions: the forebrain, midbrain and hindbrain. The forebrain handles higher-level thinking — language, consciousness and abstract reasoning. In contrast, the hindbrain, located at the back of the skull and often called the brain stem, controls essential, automatic functions that keep us alive: breathing, sleeping, and regulating our heartbeat and hunger urges. The hindbrain neurons also control the muscles of the face, tongue and throat, which affect speech and swallowing.

Despite the critical importance of the hindbrain, scientists have struggled for decades to generate human hindbrain neurons in the laboratory. This gap has hampered research into devastating diseases affecting the brain stem, including spinal muscular atrophy and amyotrophic lateral sclerosis...

We have long known that the Sun is active. It “flares” quite often, sending huge amounts of energy off in a certain direction - sometimes directly at Earth. But we also know that, compared to other Sun-like stars, it seems relatively quiet, and not capable of producing the “superflares” we sometimes see in its stellar equivalents. That sounds like great news for humanity, and some scientists have even argued that lack of superflares was a critical impetus for the development of complex life on Earth. But a new paper from Natalie Krivova of the Max Planck Institute for Solar System Research and her co-authors in the journal Philosophical Transactions A calls the assumption that our Sun is incapable of such dramatic outbursts into question. That also means that, eventually, our highly technological society could bear the brunt of one of them.

Scientists have been collecting data on the Sun for decades, and one of the most interesting features they watch out for are solar flares. These massive outbursts of energy occur when the twisted magnetic fields located in what are known as the Sun’s “Active Regions” (ARs) snap and reconnect, releasing a huge amount of stored energy. Commonly known as “sunspots”, ARs also leave behind a residual glowing area known as “flare ribbons” that occur after their high-power snap-back.

Using data collected by NASA’s Solar Dynamics Observatory between 2010 and 2016, the authors analyzed what they believed to be a critical relationship - between the total area of an Active Region, the size of its resultant flare ribbons, and the total energy released during their creation. They found a very accurate statistical correlation that also makes sense intuitively - the larger the active region, the larger the ribbon area, and the more maximum potential flare energy. And critically, they found the flare energy scales exponentially with the ribbon area...