Adjusting to a new time zone or work schedule can leave the body's internal clock out of sync for days, contributing to sleep disruption, metabolic changes and other health consequences. Researchers at Rice University and Northwestern University have developed an implantable cell therapy that may help the body adapt more quickly to these disruptions.

In a recent study titled "Encapsulated Leptin-Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates," encapsulated cells engineered to continuously produce the metabolic hormone leptin reduced the time required for animals to adjust to shifts in the light-dark cycle that mimic jet lag and shift work. Published in Advanced Science, the study's findings demonstrate a new approach to regulating circadian rhythms through metabolic signaling and provide early evidence that engineered cell therapies could be used to address circadian disruption.

A temporary metabolic nudge
"Current approaches for adjusting circadian rhythms rely heavily on precisely timed behaviors such as light exposure, meal schedules or melatonin administration," said Omid Veiseh, professor of bioengineering at Rice. "We wanted to explore whether a temporary cell therapy could provide a more practical way to help the body adapt to changing schedules."

The therapy consists of human retinal pigment epithelial cells engineered to produce leptin, a hormone best known for regulating appetite and metabolism. The cells are encapsulated within microscopic alginate spheres that protect them from the immune system while allowing therapeutic proteins to diffuse into the body. Following a simple subcutaneous injection, the encapsulated cells temporarily elevate circulating leptin levels before naturally losing viability over time.

"Metabolism and circadian rhythms are closely connected, but the therapeutic potential of that relationship remains largely unexplored," said Martha Hotz Vitaterna, professor of neurobiology at Northwestern University and co-corresponding author on the study. "These findings suggest that metabolic signals can be leveraged to accelerate adaptation to circadian disruptions."

Faster adjustment across species
In mouse studies, animals receiving the leptin-producing cell therapy adjusted significantly faster following both phase advances and phase delays in the light-dark cycle. Mice treated with the therapy adapted to a four-hour schedule delay 50% faster than control animals.

Long-term memories may not "stick" in the brain for the reasons we thought, a study of mice in artificial hibernation reveals.

Instead of relying on many individual, strong links between neurons — which would typically be pared down during hibernation — long-lasting memories seem to require higher-level patterns in connectivity, the study found.

"This topological architecture of the broader network seems to be more important" than individual, sturdy connections, said study co-author Kazumasa Tanaka, head of the Memory Research Unit at the Okinawa Institute of Science and Technology.

The findings, published Thursday (Aug. 13) in the journal Science, may complicate the picture of how memory retention works.

Tanaka and colleagues used hibernation to study memory because past studies of hibernating animals have found that their brains shrink and pare down cell-to-cell connections during these extended periods of low metabolic activity. At the same time, the brain's activity slows to a crawl, and the loss of connections is thought to be related to this energy-saving mechanism.

Despite this brain shrinkage, hibernating animals, such as alpine marmots (Marmota marmota) and European ground squirrels (Spermophilus citellus), still retain memories they formed before they went into hibernation. "Some studies report their memories are intact, even after, so they can remember conspecifics [members of the same species], like their friends, or they can remember the locations of their food," Tanaka told Live Science.

The new study aimed to tackle the question of what allows those memories to stick around even after many connections between brain cells disappear.

What is the Nancy Grace Roman Space Telescope? Why do we need it? What will it unveil?

Learn more about Roman and how it will help us investigate some of the many mysteries of the universe. ⬇️

Roman is set to launch Aug 30th at 7:26 am ET. Stay up to date on the mission: go.nasa.gov/45skR6q

A tiny UK-developed satellite, roughly the size of a small carry-on suitcase, could help answer one of the biggest questions in cosmology: What happened during the roughly 150 million years of the cosmic dark ages, before the universe's first stars appeared?

An international team of scientists led by the University of Cambridge will use the far side of the moon as a "shield" so the satellite—called CosmoCube—can block out all the noise from Earth and listen for a faint whisper from the very early universe.

This whisper, known as the 21-centimeter line, is a signal emitted by hydrogen atoms in the period between the afterglow of the Big Bang and cosmic dawn, when nuclear fusion lit up the first stars. No one has directly observed this era before.

Detecting this signal from more than 13.5 billion years ago is extremely difficult with Earth-based telescopes because Earth's ionosphere blocks the right frequencies, and interference from FM radio, satellites and telecommunications drowns it out.

However, the moon provides a natural shield. As CosmoCube orbits the far side of the moon, it will be shielded from all the noise from Earth for roughly 40 minutes of each 2-hour orbit. Over an expected 2-year mission, it will build up 1,000 hours of data on one of the last unexplored periods of the universe, helping us understand how the universe transitioned from dark and nearly empty to the complexity we see today.

From smartphones to data centers, modern electronics rely on billions of tiny switches that consume electricity every time they turn on or off. As global demand for computing continues to grow, so does the energy required to power it. Scientists are therefore searching for alternatives that can perform the same tasks while using far less energy.

One promising approach uses clusters of tiny magnets, each thousands of times smaller than a grain of sand. A new study led by the U.S. Department of Energy's (DOE) Argonne National Laboratory, with contributions from the DOE's Los Alamos National Laboratory and Adolfo Ibáñez University in Chile, has uncovered a geometric rule that determines whether clusters of nanomagnets behave predictably or probabilistically as they relax toward a stable state. The finding challenges standard modeling assumptions and opens new possibilities for ultralow-energy computing.

Nanomagnetic devices have already demonstrated the potential to operate using extremely small amounts of energy—possibly millions of times less than conventional electronic components. If such systems can be made reliable and scalable, they could help reduce the growing energy demands of computing infrastructure worldwide.

The new research offers a practical step toward that goal.

"We've shown that geometry alone can determine how energy moves through these magnetic systems," Arava said, "and that insight gives us a new way to design computing devices."

Over the past two decades, researchers using functional magnetic resonance imaging (fMRI), which tracks the iron in the hemoglobin supplying oxygen to neurons, have been building up increasingly detailed maps and inventories of the mammalian cortex. Thanks to huge advances in machine-learning artificial intelligence—computer algorithms that are able to sort through enormous amounts of information and use statistical methods to make classifications and predictions—fMRI scans can now be used to identify everything from depressive thoughts to the nuanced feelings of envy and schadenfreude. Other algorithms have been able to accurately piece together reconstructions of movie clips watched by subjects, just by analyzing their brain scans; or have detected, in probing the brain activity of swing voters in the US presidential election, responding to photographs and videos of presidential candidates, which candidates provoked anxiety or even disgust, and which elicited positive responses or feelings of empathy

In just the last few years, neuroscience researchers have progressed from decoding images and emotions as they play across the cortex to sounds, words, phrases, and even language. In 2023, in a remarkable demonstration of this emerging technology, a woman called Ann Johnson, who had been paralyzed for 18 years by a brain-stem stroke, was able to speak again through the insertion of a grid of 253 electrodes onto the surface of her brain, which translated her neuronal signals into sentences, in real time, at a rate of 78 words per minute (just about half the speed of standard conversation). The research team at the University of California, led by neurosurgeon Edward Chang, had combined this brain-computer interface with an animated avatar of Johnson’s head, which spoke in her own voice, as reconstructed from a recording of a 15-minute toast she had given at her wedding. Just as the avatar’s mouth spoke Johnson’s words as she thought them, so its expressions were similarly influenced by the nuances of her brain activity, which turned her thoughts about facial gestures into displays of emotion—from smiles to pursed lips and frowns...

The artificial intelligence boom is driving unprecedented demand for data centers, raising concerns about their growing energy consumption, water use and carbon footprint. These challenges are making companies look beyond traditional land-based data centers.

Some developers are now exploring the ocean as a new location for AI infrastructure, hoping underwater data centers could improve energy use and cooling efficiency while using less fresh water and land area than onshore buildings.

My research focuses on the societal, organizational and environmental implications of emerging technologies, particularly artificial intelligence and the digital infrastructure—including data centers—that supports its development and deployment. I see underwater data centers as a promising new approach for supporting the growth of AI.

But moving servers into the ocean does not make other underlying environmental challenges, such as energy consumption and carbon emissions, disappear. It also creates new concerns about harm to the marine environment, as well as questions about how these data centers can be regulated—and how companies can maintain and expand them if needed. Whether underwater data centers can become sustainable alternatives to traditional data centers depends on solving these economic, technical and environmental problems.

Scientists have long believed that tissue-resident memory T cells—which remain in tissues after an infection has cleared and respond rapidly if the threat returns—are shaped primarily by biochemical signals. A McGill University–led study has now uncovered a previously unknown ability of T cells that could change our understanding of how long-term immunity develops.

The new findings, published in Nature Immunology, reveal that T cells can sense the stiffness of the tissues around them and use these cues to help determine whether they become long-lived memory cells. Researchers suggest adapting to the greater mechanical forces found in tissues may be necessary for memory T cells to survive long term.

"This is an exciting fundamental finding that challenges the way we think about immune cells," said lead author Judith Mandl, professor in McGill's Department of Physiology. "It suggests T cells can 'feel' their surroundings and adapt to them, making the physical environment an active force in shaping their behavior."

New avenues for research
The discovery could eventually inform new approaches to treating autoimmune diseases, allergies and transplant rejection, where T cells can mistakenly attack healthy tissue.

The findings may also have implications for cancer research, the authors note.

"Tumors are often dense and physically difficult for immune cells to penetrate. Understanding how T cells adapt to these environments could help researchers design cancer immunotherapies that are better able to reach and attack tumors," said Mandl.

A new study underscores the importance of studying microbes in their natural setting rather than relying solely on laboratory research.

Researchers found that a set of corn root bacteria behaved completely differently when grown on the plant rather than in a lab, with thousands of proteins changing when placed in their natural habitat.

"Historically we've been reliant on in vitro experiments and experiments in the lab, and they're still very powerful," said Anna Garrell, a postdoctoral researcher at North Carolina State University and first author of a paper on the work published in mSystems. "But I think this is a good reminder that what you find in the lab is not necessarily what's going to be happening in the real environment."

For the study, researchers grew seven corn root bacteria both in a lab setting (in vitro) and on the plant (in planta) to measure differences in their behavior. While all the bacteria acted differently on the plant, the specifics varied from species to species.

"The biggest surprise we found was that all these bacteria interacted with the plant very differently," said Garrell. "Some, when they got to the root, became more motile and seemed to upregulate functions that would help them move and swim. Others did the exact opposite, where they would attach to the root and become much more stationary. Not all bacteria are made the same, nor do they interact with the plant the same."

Spotted: Falcon 9 [2nd stage] impact site

NASA’s Lunar Reconnaissance Orbiter (LRO) has captured images of a new crater on the Moon. The crater formed on Aug. 5, 2026, when a SpaceX Falcon 9 upper stage impacted the lunar surface. go.nasa.gov/4zw1I1g

The nature of supermassive black holes (SMBHs) is a hot topic in space science. It appears that all large galaxies like ours host an SMBH in their centers, but how these behemoths grew so massive is not clear. Neither are their origins, though most researchers agree that mergers certainly play a role.

A new discovery is bolstering the idea that mergers are behind the evolution and growth of SMBHs. Astronomers working with the JWST have found three actively accreting black holes in a single galaxy. No triple black hole galaxy has ever been seen before, though instances of three interacting galaxies with SMBHs have been observed.

The discovery is presented in new research in Astronomy and Astrophysics titled "BlackTHUNDER: Evidence of three massive black holes in a z ∼ 5 galaxy." The lead author is Hannah Übler from the Max Planck Institute for extraterrestrial Physics. The term BlackTHUNDER refers to a JWST observing program called "Black holes in the early Universe and their dense surroundings."

The galaxy in question is named J0148-4214 and it's more than 12.5 billion light years away. The JWST observed it as it appeared about 1.2 billion years after the Big Bang. BlackTHUNDER was aimed at observing black holes this old, and the JWST used its NIRSpec Integrated Field Unit to detect the three actively accreting black holes.

They have solar masses of 80 million, 0.6 million, and 2 million. The first two are closest together while the third is more distant. "“The JWST data allowed us not only to identify the three black holes, but also to estimate their masses, accretion rates, and the stellar mass of the galaxy,” said Dr. Giovanni Mazzolari, second author of the study and researcher at MPE. “We find a total stellar mass of about 1.3 billion suns, and the black holes represent a significant fraction of that.”

School was difficult for Makayla Caliendo when she was young. She remembers staring out the window while her classmates were paying attention in class. Some clothes, tags and socks were uncomfortable and left her unable to focus. She even had to repeat preschool.

“I left those early school years with less knowledge than my peers,” Caliendo wrote as a high-school senior in Attention magazine. That was back in 2021. Those experiences had “made me feel dumb.”

Scientists Say: Neurodivergent

But Caliendo wasn’t — and isn’t — dumb. Her brain just works differently than most of her peers.

Caliendo has a condition known as attention deficit/hyperactivity disorder, or ADHD. It affects how people think, learn and process information. Although sometimes called a “disorder,” ADHD is actually a neurotype. That means it’s a natural — and fairly common — variation in how the brain develops.

Some 22 million people in the United States have been diagnosed with ADHD. This includes more than 6 million children.

People with ADHD produce a lower amount of some of the chemicals that brain cells use to communicate. One is dopamine. It affects motivation and mood. Another is norepinephrine (Nor-ep-ih-NEF-rin). It plays a role in attention and excitement.

Explainer: What is dopamine?

These brain differences can make it harder for people with ADHD to focus on certain tasks when compared to folks without ADHD. People with ADHD may have trouble sitting still or controlling their emotions and actions.

Such traits are not always a problem, notes Jamal Williams at the University of Buffalo in New York. He studies the genetics behind ADHD. People have had traits linked to ADHD for a very long time. Recent research suggests ADHD-like behaviors, such as risk-taking and impulsivity, would have made people better foragers in ancient hunter-gatherer societies.

However, people today are expected to sit still in classes and offices. They may have to be quiet for hours at a time. This can make it difficult for people with ADHD to succeed in such environments.

Rice University researchers have shown that tiny wrinkles in graphene can change the material's electrical properties, providing evidence for flexoelectricity, a phenomenon in which a material generates an electric charge when it bends unevenly. The findings are published in Advanced Materials.

The discovery suggests scientists may be able to control electricity in atomically thin materials by changing their shape instead of adding new chemicals or materials. The approach could one day lead to more sensitive sensors and ultrathin electronic devices.

"Our work shows that even an ordinary wrinkle can become an extraordinary electronic feature when viewed at the atomic scale," said Pulickel Ajayan, the Benjamin M. and Mary Greenwood Anderson Professor of Engineering and co-corresponding author of the study. "By demonstrating that geometry alone can reshape electrical behavior in graphene, we open a new pathway for designing materials whose properties can be controlled through structure rather than chemistry."

A new AI framework, known as SHIC-XE, has been developed to detect signs of pain in horses from video analysis while providing stable, anatomically consistent explanations for its decisions. The framework was developed by an international team of researchers led by Dr. Marcelo Feighelstein, head of the Artificial Intelligence Systems Engineering Program at Tel-Hai University's new Cluster of Engineering and Advanced Computing.

For the first time, these AI-generated explanations can be quantitatively compared with expert assessments, representing a significant breakthrough in the field of explainable artificial intelligence and an important step toward AI systems that can be trusted in real-world clinical and health care environments.

The study, published in the International Journal of Computer Vision, addresses a longstanding challenge in both veterinary and human medicine: how to identify pain and distress in individuals who cannot communicate what they are experiencing.

Building a bridge between humans and animals
Animals cannot express pain in words, and even experienced veterinarians and caregivers can struggle to recognize signs of suffering. Feighelstein's research aims to bridge that communication gap by using artificial intelligence to interpret facial expressions, body language and movement patterns. Over the years, his team and collaborators have developed AI-based tools capable of recognizing pain and emotions in cats, dogs, rabbits, sheep, cattle and now horses.

"My motivation is to build a bridge between humans and animals," said Feighelstein. "We want to give a technological voice to those who have no words, allowing caregivers and professionals to better understand their condition, their emotions and their suffering."

A major challenge in AI-based video analysis is explainability. Existing methods often highlight different areas of an image from one video frame to the next, creating unstable and difficult-to-interpret explanations. To overcome this limitation, the researchers developed SHIC-XE, a novel framework that projects the model's attention onto a fixed three-dimensional representation of a horse's face. The result is a consistent anatomical explanation, even when the horse moves, changes its head position or is filmed from different angles.

Due to an ongoing commercial spacecraft attitude control issue, NASA and Katalyst Space announced Wednesday the LINK spacecraft will not capture or boost an agency satellite to a higher altitude to extend its science mission as planned. However, LINK still will attempt to conduct rendezvous and proximity operations with NASA’s Neil Gehrels Swift Observatory to demonstrate key capabilities for the future of space exploration.

NASA and Katalyst are working closely to assess next steps for rendezvous and gather as much data as possible to inform future satellite servicing operations.

Without intervention, NASA anticipates Swift is likely to re-enter Earth’s atmosphere later this year.

Read more:
go.nasa.gov/4ggh7ty

A poop transplant — otherwise known as a fecal microbiota transplant (FMT) — may help adults with long-term insomnia sleep better, a small study suggests.

After the transplant, study participants' gut bacteria became more diverse than an untreated group of people with insomnia. Their sleep efficiency, meaning the percentage of time they spent asleep while in bed, also increased, researchers reported July 22 in the Journal of Internal Medicine.

If future studies confirm that FMT is safe and effective for the treatment of insomnia, it could become another tool against the sleep disorder, joining sleeping pills and cognitive behavioral therapy (CBT).

For decades, both scientific theories and everyday thinking have treated decision-making as a separate step between perception and action. Under this traditional view, information moves through a linear sequence from sensing to thinking to acting, with each stage linked to a distinct brain function.

Many research methods, especially those used in model-based cognitive neuroscience, are built around this idea and reinforce it. It also matches our everyday experience. As James puts it, “Our actions feel like they are caused by decisions based on desires, beliefs, and intentions.”

However, James argues that this linear framework, often called the “sandwich model,” does not fit what scientists know about the brain. While researchers have identified neural systems for sensing and movement, there is no comparable brain mechanism that clearly serves as a dedicated decision-making stage.

From Decision-Making to Action Selection
Instead of proposing a separate decision-making center that directs behavior, James argues that actions emerge from the combined activity of sensory, sensorimotor, and motor processes. He prefers the term “action selection,” which reflects an ongoing interaction among the brain, body, and environment rather than a simple step-by-step process. He says this view also requires research methods that can better capture these dynamic interactions.

That does not mean decisions are unreal.

As James explains, “Of course they do. We use this language all the time, and it’s very helpful in terms of describing behavior. The leap, I think, is to say that the brain works by having decision-making or control processes. It produces behavior that is well described in that way. But it doesn’t need a process that does that to make it look that way.”

Bepi Colombo is approaching Mercury 🛰️🌑☀️ And we’re here for it! 🙌

On 3 September, the European Space Agency / JAXA en mission will carry out its first arrival manoeuvre, kicking off the Mercury Arrival Phase.

Want to watch live on 3 Sept?

Stay tuned here and on ESA Science for more details on 27 August 🗓️

This year's El Niño is on track to be the strongest on record, threatening to unleash extreme weather across the globe and make 2027 the hottest recorded year by far. It is expected to be the most "intense" El Niño in more than a century, the head of long-range forecasting at the U.K.'s Met Office warned Friday.

Stacked on top of long-term human-caused climate change, the temporary jolt will offer a glimpse of the heat the world can expect by the late 2030s, experts say.

Here's what to know.

Perspective is everything. 🌍 Gazing down at Earth from above offers an incredibly profound one, as does looking back at the Space Station from a window in the Russian segment. Our crewmate Anna Kikina captured this incredible footage during Anil Menon and my spacewalk on Aug. 6. Even suited up in our bulky spacesuits, we look like tiny little worker bees at the hive given the massive scale of the station.