2⃣.5⃣
🔘Summarize the thermodynamic hypothesis.

🔘Explain how Anfinsen's experiment supports the thermodynamic hypothesis.

🔘Explain how folding funnels are used to visualize protein folding thermodynamics.

@Medterms
@Essential_Biochemistry

📌متن ویدئو۲.۵
@Medterms
@Essential_Biochemistry

2⃣.6⃣
🔘Explain the role of cooperativity in protein folding.

🔘Summarize the theoretical basis of Levinthal's paradox.

🔘Describe the diffusion collision and nucleation condensation models of protein folding.

@Medterms
@Essential_Biochemistry

📌متن ویدئو۲.۶
@Medterms
@Essential_Biochemistry

2⃣.7⃣
🔘Explain why there is a risk of aggregate formation for proteins folding in the cytosol.

🔘Summarize how different chaperones function to prevent protein aggregation.

🔘Explain why heat shock causes protein aggregation.

🔘Compare the chaperone function of HSP70 and HSP60.

@Medterms
@Essential_Biochemistry

📌متن ویدئو۲.۷
@Medterms
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3⃣.1⃣

🔘Define reaction equilibrium

🔘Determine if a reaction is spontaneous based on the free energy of the reaction coordinates.

🔘Explain how a catalyst reduces the activation energy to speed the rate of a reaction.

🔘Understand that an enzyme stabilizes a transition state to decrease the activation energy of a reaction.

@Medterms
@Essential_Biochemistry

📌متن ویدئو۳.۱
@Medterms
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3⃣.2⃣

🔘Recall that transient covalent bonds position the substrate in the enzyme active site to reduce the entropy of the system.

🔘Explain how weak non-covalent interactions (i.e. binding energy) reduce activation energy.

🔘Contrast Emil Fischer's lock-and-key model of enzyme specificity with the 'induced fit' hypothesis of enzyme catalysis.

🔘Define desolvation as it relates to binding energy.

#Enzyme #Catalysis

@Medterms
@Essential_Biochemistry

📌متن ویدئو۳.۲
@Medterms
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3⃣.3⃣

🔘Explain why enzymes are much bigger than their respective active sites.

🔘Describe the 3-point attachment model of enzyme catalysis.

🔘Recall the role of sequential substrate binding and induced fit in enzyme catalysis. 

🔘Understand the role of phosphorylation in enzyme regulation.

♦️PLEASE NOTE: in video at 8:14, and in the slides, the charge sign is missing on the left most oxygen atom of citrate. It should appear as follows.

@Medterms
@Essential_Biochemistry

📌متن ویدئو۳.۳
@Medterms
@Essential_Biochemistry

🔸🔸🔸🔸Software🔸🔸🔸🔸

📍PyMOL➖➖➖➖➖➖➖1⃣

🆙Please share it.

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@Essential_Biochemistry

📣 از مطالب کانال راضی هستین؟
public poll

بله، ولی ارسال ها کم است – 98
👍👍👍👍👍👍👍 61%

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👍👍👍 27%

خیر، مطالب غیر مرتبط زیاد است – 12
👍 7%

خیر ، مطالب مفید نیستند – 8
👍 5%

👥 161 people voted so far.

📌متن ویدئو اموزش نرم افزار PyMOL قسمت اول
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3⃣.4⃣

🔘Describe regulation by post-translational proteolysis of proteins.

🔘Understand the importance of signaling peptides.  

🔘Define a zymogen. 

🔘Work through the processing of chymotrypsinogen as an example of an enzyme being regulated by post-translational proteolysis. 

🔘Work through the processing of insulin as a non-enzymatic example of regulation by post-translational proteolysis. 

#protein #processing

@Medterms
@Essential_Biochemistry

3⃣.5⃣
Learning goal:

🔘Provide a detailed explanation of the blood clotting process and the role of proteolytic activation of proteins implicated in blood coagulation and hemostasis. 

Learning objectives:

🔘Paraphrase the three phases and key cellular components involved with the blood clotting process.

🔘Explain the role of proteolytic processes in the coagulation cascade and fibrin polymer formation.

🔘List the multiple functions of thrombin in the coagulation cascade.

🔘Describe inhibitory mechanisms of the coagulation cascade.

🔘Discuss the effects of too little or too much activation of the coagulation cascade on hemostasis. 

@Medterms
@Essential_Biochemistry

Look at these dynamics! Interaction between Tubulin and Mitochondria in HUVECs imaged with the sensitive RCM. Tubulin Live 550 kindly provided by Abberior. Mitochondrial dye is the new PK Mito Deep Red probe kindly provided by the Chen lab.

#Peter #Drent


@cytology
@medterms
@IranBiologists
@essential_biochemistry

3⃣.6⃣

Understand the working principle of MRI and MRI probesUnderstand the coagulation pathway and which parts of the pathway are appropriate targets for early thrombus detectionUnderstand phage screen technology and how it can be used to identify probes

#thrombus #detection

@Medterms
@Essential_Biochemistry

4⃣.1⃣

🔘Describe a typical experimental setup to measure enzyme kinetics.

🔘Explain why enzymes achieve a maximum velocity (Vmax).

#Enzyme #kinetics

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@Essential_Biochemistry

♦️🔹♦️🔹♦️🔹♦️🔹♦️🔹♦️🔹♦️🔹♦️

با سلام و آرزوی تندرستی 🌿🌷

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🔅 بعد از اتمام و تسلط نسبی بر مطالب بیوشیمی ساختار و به دنبال آن بیوشیمی متابولیسم؛ به منظور آشنایی با نحوه مقاله خوانی و مقاله نویسی؛ تعدادی مقاله همراه با تفسیری کوتاه و آموزش های مربوطه را برای شما عزیزان ارائه خواهیم کرد.

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