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🍂🌺🍂 Cardiac Troponin
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🔰The most sensitive and specific test for myocardial damage. Because it has increased specificity compared with CK-MB, troponin is a superior marker for myocardial injury. Troponin is released during MI from the☞cytosolic pool of the myocytes. Its subsequent release is prolonged with☞degradation of actin and myosin filaments . Isoforms of the protein, T and I, are specific to myocardium.

🔰Clinical interpretation
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The initial rise in cardiac troponins ( cTnI and cTnT) after myocardial infarction occurs at about the same time as CK and CK–MB (4 to 8 hours), but this rise continues for longer time (days to weeks) after AMI.

【 التربونين يوجد في سيتوبلازم الخلايا القلبية على شكل بروتين حر، والغالب مرتبط بالياف العضلة ، لذا فهو يرتفع تدريجيا بعد الاحتشاء القلبي بسبب خروج التروبونين الحر ويصل الى ارتفاع عالي ، ثم يبدأ بالهبوط بعد 24 ساعة ولكنه يظل فوق المستوى الطبيعي ، ثم يرتفع مرة اخرى اعلى من الارتفاغ الاول بسبب انطلاق التروبونين المرتبط بالالياف】.
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🔰Troponin is a complex of three protein subunits:
شاهد الفيديو👇👇في الاسفل..

1⃣Troponin C(calcium-binding subunit (TnC, 18 kDa)..
2⃣Troponin I(inhibitory subunit,TnI, 24 kDa),.
3⃣Troponin T(tropomyosin-binding subunit,TnT, 37 kDa),).

🔸TnC, the forms found in type 2 fibers and cardiac muscle are identical, obviating its use as a differential marker.

🔸TnI has a cardiospecific form (cTnI). The presence of the cardiospecific form in tissue other than cardiac muscle has never been documented.

🔸TnT has been detected in fetal skeletal muscle and diseased skeletal muscle. However, post-translational modifications cause detectable differences between cTnT produced in myocardium and cTnT produced in diseased skeletal muscle. Hence an immunochemical test should have myocardial specificity approaching 100% specificity. Nevertheless, small increases in circulating cTnT, even with newer assays, have been reported in patients with muscular dystrophy and renal failure who have no other evidence of cardiac disease.

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Troponin role in muscle contraction

62- من الاخطاء الايجابية التي تؤثرعلى الفحوصات في عينة السيرم￤
➢Lipemic
➢Old serum
➢Contaminated serum
والاخطاء السلبية￤
➢Antibiotic therapy
➢Hemolysed sample

💟 #خواطر_مخبرية
🕳قناة↜ @LabMed2016
🕳بوت↜ @Lab_Med_ALMAS_bot

64- أفضـل Dilution مستخدم لتخفيف العينات الدهنية ،او التي تجاوزت Linearty
هو بنسبة 1 : 10【100ميكرونSample + ميكرون900 R. dilution】 والناتج يضرب 10x

💟 #خواطر_مخبرية
🕳قناة↜ @LabMed2016
🕳بوت↜ @Lab_Med_ALMAS_bot

http://www.chemistryguide.org/

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كل سوائل الجسم وما يندرج ضمنها ،،
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☞ @Biochem_Lab ☜
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