مُبارٓكٌ علٓيْكم شّٓهرُ رٓمٓضٓان 🌒
وكل عام وأنتم بخير وصحة وعافية ❤️
اعاده الله علينا وعليكم بالخير واليمن والبركات ♥️🌙
وكل عام وأنتم بخير وصحة وعافية ❤️
اعاده الله علينا وعليكم بالخير واليمن والبركات ♥️🌙
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-الحمد لله جزء العملي اتسجل وحاليا بيتبعت و المده مش كبيره ٣٧ دقيقه فقط.
-مش متخيل ان دا اخر فيديو خلاص هسجلوا ليكم حابب اشكركم لانكم كنتوا السبب في اني اكمل لحد دلوقت بسبب دعمكم ليا وربنا يعلم معزتكم عندي قد اي اتمني من ربنا انه يوفقكم ف السنين الجيه ويرزق كل واحد فيكم بالتخصص الي هيكون خير ليه واخيرا متنسونيش من دعواتكم.💙
-مش متخيل ان دا اخر فيديو خلاص هسجلوا ليكم حابب اشكركم لانكم كنتوا السبب في اني اكمل لحد دلوقت بسبب دعمكم ليا وربنا يعلم معزتكم عندي قد اي اتمني من ربنا انه يوفقكم ف السنين الجيه ويرزق كل واحد فيكم بالتخصص الي هيكون خير ليه واخيرا متنسونيش من دعواتكم.💙
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هتلاقي واحد كلاون دلوقت بيذاكر ف ال ٥٠٠ محاضره فسيو عشان عليهم ٩ درجات ويسيب محاضره البايو الي عليها ٣ درجات مضمونين والله.
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شباب عشان انا عكست بين الخطوتين بس في الريكورد
-تصنيع ال carbamoyl P بيحول
2ATP to 2 ADP.
-تصنيع ال Arginosuccinate بيحول
ATP to AMP.
-تصنيع ال carbamoyl P بيحول
2ATP to 2 ADP.
-تصنيع ال Arginosuccinate بيحول
ATP to AMP.
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بص علي دول كدا وبعون الله تضمن ال ٣ درجات:-
-major source of ammonia is transdeamination reactions but there is minor sources as purine and pyrimidine deamination and bacterial putrefaction.
-main site for deamination reactions is liver.
-anabolic pathways for ammonia
Used for synthesis of non-essential amino acids as glutamine.
-ammonia from most tissue especially brain go to liver in the form of glutamine.
-ammonia from muscles go to liver in the form of alanine.
-ammonia produced in kidney excreted directly in urine and not go to liver.
-urea cycle occur in liver only in mitochondria and cytosol.
-the rate limiting enzyme is carbamoyl phosphate synthetase-1 and this enzyme activated by Mg and Mn and n-acetylglutamate.
-reactions used ATP is formation of carbamoyl phosphate and arginosuccinate.
-amino acids used in urea cycle is Arginine - aspartate - ornithine.
-ornithine is regenerated every urea cycle.
-one of links between urea cycle and TCA cycle is fumarate.
-the first amino group enter urea cycle carried by carbamoyl phosphate.
-the 2nd amino group transferred for citrulline from aspartate.
-the carbon source in urea cycle is CO2.
-carbamoyl phosphate and citrulline only produced in mitochondria.
-nitrogen attoms in urea produced from NH3 and aspartate.
-Brain is very sensitive for ammonia toxicity.
-in renal failure urea level increased and ammonia level is normal.
-in liver failure ammonia level increase.
-type 1 hyperammonemia caused by deficiency in CPS-1.
-type2 caused by deficiency in ornithine transcarbamoylase( the most common type).
-citrullinimia type-1 due to deficiency in arginosuccinate synthetase.
-citrullinimia type-2 due to deficiency in citrin(transport of aspartate).
-arginosuccinic aciduria due to deficiency in arginosuucinate lyase.
-HHH due to deficiency in ornithine transport.
-homocitrulline produced when carbamoyl phosphate react with lysine. مهمه
-ammonia is toxic to Brain because its depelate alpha ketoglutarate which is essential for TCA cycle so ATP production will decrease.
-major source of ammonia is transdeamination reactions but there is minor sources as purine and pyrimidine deamination and bacterial putrefaction.
-main site for deamination reactions is liver.
-anabolic pathways for ammonia
Used for synthesis of non-essential amino acids as glutamine.
-ammonia from most tissue especially brain go to liver in the form of glutamine.
-ammonia from muscles go to liver in the form of alanine.
-ammonia produced in kidney excreted directly in urine and not go to liver.
-urea cycle occur in liver only in mitochondria and cytosol.
-the rate limiting enzyme is carbamoyl phosphate synthetase-1 and this enzyme activated by Mg and Mn and n-acetylglutamate.
-reactions used ATP is formation of carbamoyl phosphate and arginosuccinate.
-amino acids used in urea cycle is Arginine - aspartate - ornithine.
-ornithine is regenerated every urea cycle.
-one of links between urea cycle and TCA cycle is fumarate.
-the first amino group enter urea cycle carried by carbamoyl phosphate.
-the 2nd amino group transferred for citrulline from aspartate.
-the carbon source in urea cycle is CO2.
-carbamoyl phosphate and citrulline only produced in mitochondria.
-nitrogen attoms in urea produced from NH3 and aspartate.
-Brain is very sensitive for ammonia toxicity.
-in renal failure urea level increased and ammonia level is normal.
-in liver failure ammonia level increase.
-type 1 hyperammonemia caused by deficiency in CPS-1.
-type2 caused by deficiency in ornithine transcarbamoylase( the most common type).
-citrullinimia type-1 due to deficiency in arginosuccinate synthetase.
-citrullinimia type-2 due to deficiency in citrin(transport of aspartate).
-arginosuccinic aciduria due to deficiency in arginosuucinate lyase.
-HHH due to deficiency in ornithine transport.
-homocitrulline produced when carbamoyl phosphate react with lysine. مهمه
-ammonia is toxic to Brain because its depelate alpha ketoglutarate which is essential for TCA cycle so ATP production will decrease.
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