๐ข3
A 60-year-old patient with relapsed, refractory Hodgkin's Lymphoma has poor performance status and is not a candidate for high-dose chemotherapy and HSCT.
Which class of agents is explicitly mentioned as an approved option for such patients?
Which class of agents is explicitly mentioned as an approved option for such patients?
Anonymous Quiz
20%
a) Anti-CD20 monoclonal antibodies (e.g., rituximab)
8%
b) PI3K inhibitors (e.g., idelalisib)
15%
c) Radioimmunoconjugates (e.g., 90Y-ibritumomab tiuxetan)
53%
d) PD-1 pathway inhibitors (e.g., nivolumab)
4%
e) Oral alkylating agents (e.g., chlorambucil)
โค3
Which of the following unique toxicities are associated with the ABVD regimen?
Anonymous Quiz
51%
A. Pulmonary fibrosis
6%
B. Hemorrhagic cystitis
3%
C. Hepatic encephalopathy
3%
D. Osteopenia
37%
E. All of the above
๐ข5โค4
A patient completed initial therapy with 8 weeks of chemotherapy. According to the initial
therapy strategy, what is the next step in managing this patient's treatment?
therapy strategy, what is the next step in managing this patient's treatment?
Anonymous Quiz
10%
a) Begin a 5-year course of maintenance chemotherapy.
4%
b) Immediately proceed to a bone marrow transplant.
75%
c) Perform a restaging PET-CT scan to assess response.
7%
d) Administer a high-dose salvage chemotherapy regimen.
4%
e) Schedule a follow-up appointment in one year with no further tests.
โค6
A pathologist is differentiating between Hodgkin's Lymphoma (HL) and Non-Hodgkin's
Lymphoma (NHL).
Which of the following statements accurately reflects a key
pathological distinction?
a) HL is derived from a monoclonal proliferation of B or T lymphocytes, while NHL is characterized by the Reed-Sternberg cell.
b) Both HL and NHL are characterized by the presence of Reed-Sternberg cells.
c) NHL is a term covering all lymphoproliferative malignancies except HL, which is distinguished by the Reed-Sternberg cell.
d) HL is a B-cell malignancy, whereas NHL always involves T-cell proliferation.
e) The diagnosis of both HL and NHL relies on the presence of B-symptoms.
Lymphoma (NHL).
Which of the following statements accurately reflects a key
pathological distinction?
a) HL is derived from a monoclonal proliferation of B or T lymphocytes, while NHL is characterized by the Reed-Sternberg cell.
b) Both HL and NHL are characterized by the presence of Reed-Sternberg cells.
c) NHL is a term covering all lymphoproliferative malignancies except HL, which is distinguished by the Reed-Sternberg cell.
d) HL is a B-cell malignancy, whereas NHL always involves T-cell proliferation.
e) The diagnosis of both HL and NHL relies on the presence of B-symptoms.
โค6๐3
Staging of lymphoma
Stage I
ุงุฐุง ู ุฌู ูุนุฉ ูุงุญุฏุฉ ู ู ุงูุนูุฏ ุงู ุนูุฏุฉ ูุงุญุฏุฉ
ุงู ุนุถู ูู ูุงูู ูุงุญุฏ ู ุตุงุจ
Stage II
ุงุฐุง ุนูุฏุชูู ุงู ุงูุซุฑ ุงู ู ุฌู ูุนุชูู ู ู ุงูุนูุฏ ุจุณ ุจุดุฑุท ุงูู ูููุง ุจููุณ ุงูุฌูุฉ ูู ููู ููู ุงู ุชุญุช ุงูุญุฌุงุจ ุงูุญุงุฌุฒ
ู ุซูุง ุงูุนูุฏ ุงูู ุตุงุจุฉ ุจุงูุฑูุจุฉ ูุชุญุช ุงูุงุจุท ููุง ู ุฌู ูุนุชูู ูุงุซููููู ููู ุงูุญุฌุงุจ ุงูุญุงุฌุฒ
Stage III
ู ุฌู ูุนุชูู ุงู ุงูุซุฑ ู ู ุงูุนูุฏ ุงููู ูุงููุฉ ู ุตุงุจุฉ ููู ุจุดุฑุท ุงูู ุชููู ููู ูุชุญุช ุงูุญุฌุงุจ ุงูุญุงุฌุฒ
ุงู
ู ุฌู ูุนุฉ ู ู ุงูุนูุฏ ููู ุงูุญุฌุงุจ ุงูุญุงุฌุฒ ูููุงูู ุงูุทุญุงู ู ุตุงุจ
Stage IV
ุงูุชุดุงุฑ ุจุนูุฏ
ุชูุชูู ูุฐู ุงูุฎูุงูุง ู ู ุงูุฏู ุงูู ุงุนุถุงุก ุฎุงุฑุฌ ุงูุฌูุงุฒ ุงููู ูุงูู
ู ุซูุง ุจ ุงู bone marrow ุ lungุ liver
ุงุฐุง ู ูุฌูุฏุฉ ุงู B symptoms ูุถูู ุงูุฑู ุฒ B ู ุน ุงุณู ุงูู ุฑุญูุฉ
ุงุฐุง ู ุง ู ูุฌูุฏุฉ ูุฎูู A
ุงุฐุง ุงูุงุตุงุจุฉ ู ูุชุดุฑุฉ ุฎุงุฑุฌ ุงูุนูุฏ ุงููู ูุงููุฉ local extension ูุนูู ุงู ุชุฏุช ููุงูุณุฌุฉ ุงูู ุฌุงูุฑุฉ ู ุซูุง ููุฌูุฏ ุงู ุงูุนุถูุงุช ูุฎูู ุงูุฑู ุฒ E
ุงู ุง ุงูุฑู ุฒ X ูู ุนูุงูุง bulky
ุงุฐุง ุญุฌู ุงููุฑู ุงูุจุฑ ู ู ุซูุซ ุนุฑุถ ุงูุตุฏุฑ ุงู ุงุฐุง ุงุญุฏ ุงุจุนุงุฏ ุงููุฑู (ุทูู ุ ุนุฑุถ ุ ุงุฑุชูุงุน) ุฌุงู ุงูุซุฑ ู ู 10cm ูุถูู ุงูุฑู ุฒ X
#Lymphoma
Stage I
ุงุฐุง ู ุฌู ูุนุฉ ูุงุญุฏุฉ ู ู ุงูุนูุฏ ุงู ุนูุฏุฉ ูุงุญุฏุฉ
ุงู ุนุถู ูู ูุงูู ูุงุญุฏ ู ุตุงุจ
Stage II
ุงุฐุง ุนูุฏุชูู ุงู ุงูุซุฑ ุงู ู ุฌู ูุนุชูู ู ู ุงูุนูุฏ ุจุณ ุจุดุฑุท ุงูู ูููุง ุจููุณ ุงูุฌูุฉ ูู ููู ููู ุงู ุชุญุช ุงูุญุฌุงุจ ุงูุญุงุฌุฒ
ู ุซูุง ุงูุนูุฏ ุงูู ุตุงุจุฉ ุจุงูุฑูุจุฉ ูุชุญุช ุงูุงุจุท ููุง ู ุฌู ูุนุชูู ูุงุซููููู ููู ุงูุญุฌุงุจ ุงูุญุงุฌุฒ
Stage III
ู ุฌู ูุนุชูู ุงู ุงูุซุฑ ู ู ุงูุนูุฏ ุงููู ูุงููุฉ ู ุตุงุจุฉ ููู ุจุดุฑุท ุงูู ุชููู ููู ูุชุญุช ุงูุญุฌุงุจ ุงูุญุงุฌุฒ
ุงู
ู ุฌู ูุนุฉ ู ู ุงูุนูุฏ ููู ุงูุญุฌุงุจ ุงูุญุงุฌุฒ ูููุงูู ุงูุทุญุงู ู ุตุงุจ
ุทุจุนุง ู ุตุงุฏุฑ ููุงู ู ุฎุชููุฉ ุจูุฐู ุงูู ุฑุญูุฉ ุจุณ ุงูุงุตุญ ุงูู ูุชุจุชู ููู ููู ููุณ ุงูู ุตุฏุฑ
Stage IV
ุงูุชุดุงุฑ ุจุนูุฏ
ุชูุชูู ูุฐู ุงูุฎูุงูุง ู ู ุงูุฏู ุงูู ุงุนุถุงุก ุฎุงุฑุฌ ุงูุฌูุงุฒ ุงููู ูุงูู
ู ุซูุง ุจ ุงู bone marrow ุ lungุ liver
ุงุฐุง ู ูุฌูุฏุฉ ุงู B symptoms ูุถูู ุงูุฑู ุฒ B ู ุน ุงุณู ุงูู ุฑุญูุฉ
ุงุฐุง ู ุง ู ูุฌูุฏุฉ ูุฎูู A
ุงุฐุง ุงูุงุตุงุจุฉ ู ูุชุดุฑุฉ ุฎุงุฑุฌ ุงูุนูุฏ ุงููู ูุงููุฉ local extension ูุนูู ุงู ุชุฏุช ููุงูุณุฌุฉ ุงูู ุฌุงูุฑุฉ ู ุซูุง ููุฌูุฏ ุงู ุงูุนุถูุงุช ูุฎูู ุงูุฑู ุฒ E
ุงู ุง ุงูุฑู ุฒ X ูู ุนูุงูุง bulky
ุงุฐุง ุญุฌู ุงููุฑู ุงูุจุฑ ู ู ุซูุซ ุนุฑุถ ุงูุตุฏุฑ ุงู ุงุฐุง ุงุญุฏ ุงุจุนุงุฏ ุงููุฑู (ุทูู ุ ุนุฑุถ ุ ุงุฑุชูุงุน) ุฌุงู ุงูุซุฑ ู ู 10cm ูุถูู ุงูุฑู ุฒ X
#Lymphoma
โค15
The patient with 2 swollen lymph nodes on the above diaphragm side also has B-symptoms, with a lymph node diameter of 15 cm.
ุดูู ุงูู ุฑุญูุฉุ
ุดูู ุงูู ุฑุญูุฉุ
โค8
The International Prognostic Factors Score (IPS) for advanced NHL lists seven adverse prognostic factors.
Which of the following correctly pairs a factor with its threshold value as listed in the text?
Which of the following correctly pairs a factor with its threshold value as listed in the text?
Anonymous Quiz
8%
a) Hemoglobin <12.0 g/dL
11%
b) Age โฅ60 years
61%
c) Serum albumin <4 g/dL
7%
d) Lymphocyte count > 600 cells/mmยณ
13%
e) Female gender
A patient with advanced, bulky Stage II follicular lymphoma is being evaluated.
The management of advanced indolent lymphoma is controversial because standard approaches are not curative What is the median time to relapse mentioned for these patients?
The management of advanced indolent lymphoma is controversial because standard approaches are not curative What is the median time to relapse mentioned for these patients?
Anonymous Quiz
17%
a) 18-36 years
3%
b) 60-80 months
58%
c) 18-36 months
20%
d) 18-36 weeks
1%
e) 12-15 years
โค2
A 68-year-old patient is diagnosed with Stage I follicular lymphoma (an indolent NHL).
According to the treatment guidelines, what is the standard, potentially curative treatment option for this patient?
According to the treatment guidelines, what is the standard, potentially curative treatment option for this patient?
Anonymous Quiz
24%
a) Watchful waiting
7%
b) High-dose chemotherapy with autologous HSCT
54%
c) Loco-regional radiation therapy (RT)
10%
d) R-CHOP chemotherapy for 6 cycles
5%
e) Single-agent oral cyclophosphamide
A patient is about to receive their first dose of rituximab for follicular lymphoma.
Which of the following is the standard pretreatment regimen recommended 30 minutes before the infusion to mitigate common adverse effects?
Which of the following is the standard pretreatment regimen recommended 30 minutes before the infusion to mitigate common adverse effects?
Anonymous Quiz
3%
a) Intravenous diphenhydramine 50 mg and oral lorazepam 1 mg
86%
b) Oral acetaminophen 650 mg and oral diphenhydramine 50 mg
7%
c) Intravenous methylprednisolone 125 mg and oral ondansetron 8 mg
2%
d) Oral ibuprofen 400 mg and famotidine 20 mg
1%
e) Subcutaneous epinephrine 0.3 mg and albuterol nebulizer.
A 65-year-old patient is diagnosed with diffuse large B-cell lymphoma (DLBCL), stage I,
with no adverse risk factors. According to the treatment guidelines for localized aggressive
lymphoma, what is a standard treatment option for this patient?
with no adverse risk factors. According to the treatment guidelines for localized aggressive
lymphoma, what is a standard treatment option for this patient?
Anonymous Quiz
12%
a) 6-8 cycles of R-CHOP with no RT.
13%
b) Loco-regional RT alone, followed by watchful waiting.
66%
c) 3 or 4 cycles of R-CHOP followed by loco-regional RT.
7%
d) High-dose chemotherapy with autologous HSCT.
2%
e) Single-agent rituximab maintenance for 2 years.
What is the most common type of lymphoma?
Anonymous Quiz
33%
A. Hodgkin lymphoma
17%
B. Folicular lymphoma
49%
C. Diffuse large B-cel lymphoma
1%
D. Mantle-cel lymphoma
0%
E. Burkitt lymphoma
Which of the following is a chemotherapy regimen utilized in the treatment of
relapsed diffuse large B-cell lymphoma?
relapsed diffuse large B-cell lymphoma?
Anonymous Quiz
34%
A. rCHOP
9%
B. MOPP
14%
C. Stanford V
39%
D. ESHAP
5%
E. rCEOP
โค2๐ฏ1
Standard chemotherapy for front-line treatment for advanced (stage III/IV) diffuse large B-cell lymphoma is:
Anonymous Quiz
5%
A. m-BACOD
17%
B. Rituximab + bendamustine
5%
C. CHOP
73%
D. Rituximab + CHOP
Forwarded from Notat || ููุชุงุช
MCQs Notat - Lymphoma.pdf
309.3 KB
โข ุงุณุฆูุฉ MCQs ุชุฎุต ุฌุงุจุชุฑ Lymphoma [ุงุณุฆูุฉ ุงูู
ุตุฏุฑ ุงูู
ุนุชู
ุฏ + ุงุณุฆูุฉ ุงุถุงููุฉ ุจูู
ุท ุงูุงู
ุชุญุงู ุงูุชูููู
ู] ุงูุญููู ุจููุงูุฉ ุงูู
ูู.
#ู ููุงุช_ููุชุงุช_ุงููุฒุงุฑูุฉ | ุนูุงุฌูุงุช .
ุนุฐุฑุงู ุจุณ ู ุง ูุญูู ู ุดุงุฑูุฉ ุงูู ููุงุช ู ุน ุงุฎูุงุก ุงุณู ุงูููุงุฉ (@Notatbkop) ูุดูุฑุงู .
โค14
Notat || ููุชุงุช
MCQs Notat - Lymphoma.pdf
ููุฐุง ุงูู
ูู ูููุฏูู
ููุงู ุจูู ุงุณุฆูุฉ ู
ุฑุชุจุฉ ูุจูู
ุท ุงููุฒุงุฑู
โค13
Forwarded from Pharmacy Topics (Qabas Hashim)
images.pdf
1.1 MB
Quize MCQ 45 point
Lymphoma
Luekemia
Lymphoma
Luekemia
โค13
Pharmacological Therapy of Insomnia
โญ Anti Histamine
โญ Anti Depressants
โญ DORA
โญ Melatonin receptor agonist
๏ปฟโญ Benzodiazepines
โญ Z drugs
#insomnia
โญ Anti Histamine
๐ซ Diphenhydramine, doxylamine and pyrilamine
ูุงู ุงูุงุฏููุฉ ุชุณุจุจ ู ุดุงูู ุฎุตูุตุง ูู ูุจุงุฑ ุงูุณู ูุงูุณุจุจ ูู ุงูู ุชู ุชูู anticholinergic effect
ู ุงูุชุจููุง ุงุฐุง ุงุฌุงูู ููุณ ู ุฑูุถ ุนูุฏู
Arrhythmia, glaucoma, BPH
โญ Anti Depressants
๐ซ Amitriptyline, Doxepin, nortriptyline๏ปฟ
ูุฐูู ูุนุชุจุฑู ุจุฏูู ูู BZD ุฎุตูุตุง ุงุฐุง ุงูู ุฑูุถ ุนูุฏู depressionุ pain, history of substance use disorder or unhealthy substance use
ููู ููู ูููู ุนุฏูู ู ุดุงูู ูุงู ุนุฏูู ูุฐุง ุงูุชุฃุซูุฑ ุงูู anticholinergic effect ููู ููู ููุชุจู ุจุงูููุณุงุช ุฎุตูุตุง ุงูู ุนุฏูู arrhythmia ูุงู ูุฃุซุฑู ุนูู ุงู cardiac conduction
Low dose doxepin โ sleep maintenance insomnia
ุงูุณุจุจ ูุงู ูู ุชูู long half life
๐ซ Mirtazapine
ูุฐุง ูู ููู ูู ุชูู long half life ูุฐูู ุงุตูุง ูุณุจุจ ุชุฃุซูุฑ ุงุณู ู hangover effect ุชุฃุซูุฑู ูุณุชู ุฑ ุญุชู ุงูููุงุฑ ูุญุชู ุจุงูููุงุฑ ุงูู ุฑูุถ ูููู ู ูุนุณ
daytime sedation
ูุณุจุจ ุฒูุงุฏุฉ ุจุงููุฒู ุจุณุจุจ ุชุฃุซูุฑู ุนูู ุงููุณุชุงู ูู
๐ซ Trazodone
ุงูู ูฃ ุญุงูุงุช ุงูุทูู ุจููุง:
ุงูู ุชุตูุฑ ุนุฏูู insomnia ุจุณุจุจ:
SSRI, Bupropion, unhealthy substance use
ุงูุชุจููุง ุงุฐุง ุงูู ุฑูุถ ุฌุงู ูุงุฎุฐ ุงุฏููุฉ ุชุฃุซุฑ ุน ุงูุณูุฑูุชูููู ูุชุฒูุฏ ู ุณุชููุงุชู ูู ุง ุงุฎุชุงุฑู ูุงู ุฑุญ ูููู ุงูู risk ูู serotonin syndrome
ุจุงูุฃุถุงูุฉ ุงูู ูุณุจุจ priapism (painful erection)
โญ DORA
๐ซ Suvorexant 10-20mg, Lemborexant 5-10mg๏ปฟ
ููุทููู ููู ุฑูุถ ุงูู ุนูุฏู ุตุนูุจุฉ ูู ุจุฏุก ุงูููู difficulty initiating sleep ุงู ููุญูุงุธ ุนูู ุงูููู maintaining sleep
ุชุณุชุฎุฏู ุจุญุฐุฑ ููู ุฑูุถ ุงูู ุนูุฏู depression ูุงู ุชุฒูุฏ ู ู ุงูุฃููุงุฑ ุงูุงูุชุญุงุฑูุฉ
ูุณุจุจู narcolepsy ุงูููู ูู ููุช ุงู ู ูุงู ุบูุฑ ู ูุงุณุจ
โญ Melatonin receptor agonist
๐ซ Ramelteon 8mg
ู ูุงุณุจ ููู ุฑูุถ ุงูู ุนูุฏู
COPD ุงู Sleep apnea
Valerian: herbal product 300-600mg
๏ปฟโญ Benzodiazepines
Estazolam, Flurazepam, Quazepam, Temazepam, Triazolam 'ETTFQุฅุชูู'๏ปฟ
๐ซ Triazolam
Short duration of action
ูุนุงููุชู ูุตูุฑุฉ ุฌุฏุง ูุงู ุจุณุฑุนุฉ ูุฑูุญ ูู cns ูููุทู ุชุฃุซูุฑู ููุฎูุต ู ูุนููู ุทุจุนุง ูุฐุง ุจุณุจุจ ุงู lipophilicity ุงูุนุงููุฉ
ูุงุฐุง ูุตูุฑ ู ุง ุฑุญ ููุทู ูุงุฆุฏุฉ ููุญูุงุธ ุนูู ุงูููู ุจุณ ู ู ูู ูุณุชูุงุฏ ู ูู ุญุชู ูุจุฏู ุงูููู ูุงู ุชุฃุซูุฑู ุณุฑูุน
๐ซ Flurazepam, Quazepam
Long duration of action
ูููุฐุง ุงูุณุจุจ ู ุง ูุณุชุฎุฏู ูู ูุฎุท ุงูู
ูุงู ู ุนูุงูุง ุงูู ุฑูุถ ุจุงูููุงุฑ ุฑุญ ูููู ู ูุนุณ ูู ุง ู ุฑูุฒ hangover effect
ูู ู ูู ุชุณุจุจ falls and hip fracture ุงูู ุฑูุถ ูุทูุญ ููุชูุณุฑ
ู ูุชุฌูุจูู ุจุงูู ุฑุถู ูุจุงุฑ ุงูุณู
๐ซ Lorazepam, Oxazepam, Temazepam
ูุฐูู ููุฏุฑ ูููู ูุชุฑุฉ ุนู ููู ู ุชูุณุทุฉ ู ู ูุงุณุจุงุช ููุจุงุฑ ุงูุณู
โญ Z drugs
Ezopiclone, Zolpidem, Zaleplon๏ปฟ
ุนุฏูู ููุท Hypnotic effect ุ ุงูู ุงุซุงุฑ ุฌุงูุจูุฉ ู ู ุงู benzodiazepines
๐ซ Zolpidem
ุจุฏุงูุฉ ุชุฃุซูุฑู ุณุฑูุนุฉ ุฎูุงู 15 ุงูู 30 ุฏูููุฉ
ูุชุฑุฉ ุนู ูู 6 ุงูู 8 ุณุงุนุงุช
ูููุฏ ูุจุฏุก ุงูููู ูููุญูุงุธ ุนูู ุงูููู ุจุณ ู ู ุงุญุณู ู ู ุงู zaleplon ูุจุฏุก ุงูููู
5mg โ female, older, pt with liver impairment
10mg โ male
๐ซ Zaleplon
ู ูุนููู ุณุฑูุน ุฌุฏุง ุงุณุฑุน ู ู ุงู zolpidem ูุงู Half life ู ุงูุชู ุชูุฑูุจุง ุณุงุนุฉ
ู ูุฐุง ูููุฏูู ุญุชู ูุจุฏู ุงูููู ู ุง ุฑุญ ูููุฏ ููุญูุงุธ ุนูู ุงูููู ูุงูู ูุชุฑุฉ ุนู ูู ูุตูุฑุฉ ุฌุฏุง.
Dose 10mg (5mg in older)
๐ซ Ezopiclone
ูุฐุง ุชุฃุซูุฑู ุณุฑูุน rapid onset ููุชุฑุฉ ุนู ูู 6 ุณุงุนุงุช
ูููุฏ ูุจุฏุก ุงูููู ูููุญูุงุธ ุนูู ุงูููู ุจุณ ู ู ุงุญุณู ู ู ุงู zaleplon ูุจุฏุก ุงูููู
ูู ู ูู ุงูู ุฑูุถ ูุณุชู ุฑ ุนููู 6 ุงุดูุฑ
#insomnia
โค25๐2๐ฏ2