Forwarded from Pathology videos & books
9) A 40-year-old woman presents with a painless lesion on her right ear lobe (shown in the image). She reports that her ears were pierced 4 months ago. Which of the following best explains the pathogenesis of this lesion?
Forwarded from Pathology videos & books
Forwarded from Pathology videos & books
The answer is E: Maturation arrest of collagen assembly. Keloid is an exuberant scar that tends to progress beyond the site
of initial injury and recurs after excision. Dark-skinned persons are more frequently affected by keloids than light-skinned people. Keloids are characterized by changes in the ratio of type III to type I collagen, suggesting a โmaturation arrestโ
in the healing process. Further support for maturation arrest
as an explanation for keloids and hypertrophic scars is the
overexpression of fi bronectin in these lesions. Keloids are
unsightly, and attempts at surgical repair are always problematic.
The other choices do not address the pathogenesis of keloids.
Diagnosis: Keloid
of initial injury and recurs after excision. Dark-skinned persons are more frequently affected by keloids than light-skinned people. Keloids are characterized by changes in the ratio of type III to type I collagen, suggesting a โmaturation arrestโ
in the healing process. Further support for maturation arrest
as an explanation for keloids and hypertrophic scars is the
overexpression of fi bronectin in these lesions. Keloids are
unsightly, and attempts at surgical repair are always problematic.
The other choices do not address the pathogenesis of keloids.
Diagnosis: Keloid
ูุฐุง ุงุญูุธูู ูุงู ุงุฌูุจู ุฏุงุฆู
ุง ุจุงูุงุณุฆูุฉ๐ฅฒ
ุงูู ูุงุนุฏุฉ ุจุงููุงุฑู ุง ุชููู ูู drug ูุจุฏู ุจุญุฑู ุงูV ูุงุฒู ุถู ู ุงูุณุงูุฏ ุงููููุช ู ุงูุชู ูุณูู visual filed loss ุชุฐูุฑู ุญุฑู ุงูv ู ู ุงูุงุซููู
ูMnemonic ุชุฐูุฑู ุงุฎุทุฑ ุตุฑุน ูู status epi
ูุฐุง ููุง ุงุฐุง ุธู ุจุฏูู ู ุง ูุฑูุญ ููุทูุงุฑุฆ ุงุญุชู ุงู ุฌุจูุฑ ูู ูุช ูุนูู die ู ุชุฐูุฑู ุงู (Di)azepam ุชูุทููู ููdie ุงูู ุฑุญ ูู ูุช๐๐
ุงูู ูุงุนุฏุฉ ุจุงููุงุฑู ุง ุชููู ูู drug ูุจุฏู ุจุญุฑู ุงูV ูุงุฒู ุถู ู ุงูุณุงูุฏ ุงููููุช ู ุงูุชู ูุณูู visual filed loss ุชุฐูุฑู ุญุฑู ุงูv ู ู ุงูุงุซููู
ูMnemonic ุชุฐูุฑู ุงุฎุทุฑ ุตุฑุน ูู status epi
ูุฐุง ููุง ุงุฐุง ุธู ุจุฏูู ู ุง ูุฑูุญ ููุทูุงุฑุฆ ุงุญุชู ุงู ุฌุจูุฑ ูู ูุช ูุนูู die ู ุชุฐูุฑู ุงู (Di)azepam ุชูุทููู ููdie ุงูู ุฑุญ ูู ูุช๐๐
ุณูุงุฑุฉ ๐ ุงูุงุทูุงู ููู ๐๐
ุณูุงุฑุฉ=Car= Carbamazepine
ููู= Phen)ytoin + (Phen)obarbital)
ูุง ุชูุทููุง ููุงุทูุงู ูุนูู ุชุฐูุฑ absence epilepsy
ุงูุทูู ุงุณู ู ุงูุซู ู ุงูุทูู ุงูุซู Ethosuximide๐๐๐๐
#ูุนูู ุดูู ุงูุตุฏ ููุงุ ุงููุตุฏ ุฅูู ุงุฏููุฉ ุงูุตุฑุน ุงูู ุชุจุฏู ุจู ูุทุน phen ุฑุงุญ ุชููู C/I in children (petit mal).. ูุฐูู ููุทูุฉ ethosuximide drug......
Key points
Carbamazepine for Trigeminal neurolagia
Ethosuximide 1st drug for absence attack
S/E Steven โ Johnson syndrome+ Urticaria
2drugs in epilepsy ____Aplastic A>>> Carbamazepine+ Ethosuximide
Alopecia>>>> Valproic acid
(Top)iramate
ูุฐุง ุงูุชูุจ Top ูุณุชุฎุฏู ููู ุงููุงุน epilepsy
Zonisamide+ Topiramate>>>>>Renal stones
lamotrigine+, phenytoin+ carbamazepine>>>>epileptic pregnant
ุงุฐุง ูุงู ุงูุงูุถู ู ููู ุงุฎุชุงุฑ lamotrigine and with 5mg folic acid
ููุดู ูุฒูุฏ ุงูGABA ูุจุฏูู ุชูููุฑ ูุนูู ูุตูุญ ููู ุงููุงุน epilepsy
Neuropathic pain drugs carbamazepine , preGABAline,and GABApentin
#1pharma
ุณูุงุฑุฉ=Car= Carbamazepine
ููู= Phen)ytoin + (Phen)obarbital)
ูุง ุชูุทููุง ููุงุทูุงู ูุนูู ุชุฐูุฑ absence epilepsy
ุงูุทูู ุงุณู ู ุงูุซู ู ุงูุทูู ุงูุซู Ethosuximide๐๐๐๐
#ูุนูู ุดูู ุงูุตุฏ ููุงุ ุงููุตุฏ ุฅูู ุงุฏููุฉ ุงูุตุฑุน ุงูู ุชุจุฏู ุจู ูุทุน phen ุฑุงุญ ุชููู C/I in children (petit mal).. ูุฐูู ููุทูุฉ ethosuximide drug......
Key points
Carbamazepine for Trigeminal neurolagia
Ethosuximide 1st drug for absence attack
S/E Steven โ Johnson syndrome+ Urticaria
2drugs in epilepsy ____Aplastic A>>> Carbamazepine+ Ethosuximide
Alopecia>>>> Valproic acid
(Top)iramate
ูุฐุง ุงูุชูุจ Top ูุณุชุฎุฏู ููู ุงููุงุน epilepsy
Zonisamide+ Topiramate>>>>>Renal stones
lamotrigine+, phenytoin+ carbamazepine>>>>epileptic pregnant
ุงุฐุง ูุงู ุงูุงูุถู ู ููู ุงุฎุชุงุฑ lamotrigine and with 5mg folic acid
ููุดู ูุฒูุฏ ุงูGABA ูุจุฏูู ุชูููุฑ ูุนูู ูุตูุญ ููู ุงููุงุน epilepsy
Neuropathic pain drugs carbamazepine , preGABAline,and GABApentin
#1pharma
Perfecto ๐๐
Photo
ูู
ูุช ๐๐ฅณุงุฐุง ุตุงุฑ ุงูู ุงุถุงูุงุช ุงู ุดุงุก ุงููู ุงุถูู ุฐูู ุงูู ุฏ ุญูุฏุฑ ุฑูุฒ ุนูููู
Perfecto ๐๐
https://youtu.be/i1b6tIIrJNc
2nd lecture of #renal pharmacology